WordNet

serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
be seated (同)sit_down
be in session; "When does the court of law sit?"
be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
holding office; "the in party"
to or toward the inside of; "come in"; "smash in the door" (同)inwards, inward
currently fashionable; "the in thing to do"; "large shoulder pads are in"
directed or bound inward; "took the in bus"; "the in basket"
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
any malignant tumor derived from epithelial tissue; one of the four major types of cancer

PrepTutorEJDIC

(…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
《具体的な場所,位置》 / …『の中に』(『で』) / …『において』,…で / 《intoの代りに移動を表す動詞と共に》…『の中へ』 / (乗り物)『に乗って』 / …『の状熊に』(『で』) / …『に従事して』,に属して / …『を身につけて』,に覆われて / 《『in』do『ing』の形で》…『するときに』,する際に(when) / 《時間》 / …『して』,…『が経過したあと』 / …『の間に』 / …『については』,…の点では / 《方法・手段・材料》…『で』 / 《人を目的語にして,性質・能力があることを示して》…の中に / …の目的で,のつもりで,として / 《比率割合》…のうちで,につき / 《過去分詞に伴って》…に[…されて] / 『中へ』(に) / 『在宅して』,帰って / (乗り物などが)『到着して』,(時期・季節が)来て / 出回って,流行して / 《俗》流行の,当世風の / 《話》特定の人々にのみ理解される
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
がん,がん腫
あり場所,位置 / (部分・器官の)正常な位置,原位置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/25 13:20:44」(JST)

wiki en

Bowen's disease (BD) (also known as "squamous cell carcinoma in situ"^[1]) is a neoplastic skin disease; it can be considered as an early stage or intraepidermal form of squamous cell carcinoma. It was named after John T. Bowen. (Erythroplasia of Queyrat is a particular type of squamous cell carcinoma in situ which can arise on the glans or prepuce in males and vulva in females, and may be induced by HPV^[2]). It is reported to occur in corneoscleral limbus.^[3]

Causes

Causes of BD include solar damage, arsenic, immunosuppression (including AIDS), viral infection (human papillomavirus or HPV), chronic skin injury, and other dermatoses.^[4]

Signs and symptoms

Bowen's disease typically presents as a gradually enlarging, well-demarcated erythematous plaque with an irregular border and surface crusting or scaling. BD may occur at any age in adults, but is rare before the age of 30 years; most patients are aged over 60. Any site may be affected, although involvement of palms or soles is uncommon. BD occurs predominantly in women (70-85% of cases). About 60-85% of patients have lesions on the lower leg, usually in previously or presently sun-exposed areas of skin.

This is a persistent, progressive, non-elevated, red, scaly or crusted plaque which is due to an intraepidermal carcinoma and is potentially malignant. The lesions may occur anywhere on the skin surface, including on mucosal surfaces. Freezing, cauterization or diathermy coagulation is often effective treatment.

Histology

Bowen's disease is essentially equivalent to squamous cell carcinoma in situ. Atypical squamous cells proliferate through the whole thickness of the epidermis. The entire tumor is confined to the epidermis and does not invade into the dermis. The cells in Bowen's are often highly atypical under the microscope, and may in fact look more unusual than the cells of some invasive squamous cell carcinomas.

Treatment

Photodynamic therapy (PDT), cryotherapy (freezing), or local chemotherapy (with 5-fluorouracil) are favored by some clinicians over excision. Because the cells of Bowen's disease have not invaded the dermis, it has a much better prognosis than invasive squamous cell carcinoma. Outstanding results have been noted with the use of imiquimod for Bowen's disease, including on the penis (erythroplasia of Queyrat), although imiquimod is not (as of 2013) approved by the U.S. Food and Drug Administration for the treatment of any type of squamous cell carcinoma, and serious side effects can occur with use of imiquimod.

Additional images

References

^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
^ J Invest Dermatol 2000 Sep;115(3):396-401
^ Syed Imtiaz Ali Shah, Saeed Ahmed Sangi, Seraj Ahmed Abbasi: Bowen’s Disease: Pak J Ophthalmol 1998 Vol. 14, No. 1.p.37-38.
^ Duncan KO, Geisse JK, and DJ Leffell. (2008). "Ch. 113: Epithelial precancerous lesions". In Wolff K; et al. Fitzpatrick's Dermatology in General Medicine (7th ed.). New York: McGraw-Hill. ISBN 978-0-07-146690-5.

External links

Photo
Histological slide
http://www.pakmedinet.com/2694

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 皮膚扁平上皮癌の治療および予後 treatment and prognosis of cutaneous squamous cell carcinoma
2. 皮膚扁平上皮癌（SCC）の臨床的特徴および診断 clinical features and diagnosis of cutaneous squamous cell carcinoma scc
3. 高リスク (浸潤性) 皮膚扁平上皮癌の認識およびマネージメント recognition and management of high risk aggressive cutaneous squamous cell carcinoma
4. 皮膚扁平上皮細胞癌および基底細胞癌における局所および遠隔転移の評価 evaluation for locoregional and distant metastases in cutaneous squamous cell and basal cell carcinoma
5. 皮膚扁平上皮癌の疫学および危険因子 epidemiology and risk factors for cutaneous squamous cell carcinoma

English Journal

Cervical FISH Testing for Triage and Support of Challenging Diagnoses: A Case Study of 2 Patients.

Hopley R, Gillespie A1.
Laboratory medicine.Lab Med.2016 Feb;47(1):52-6. doi: 10.1093/labmed/lmv003.
PATIENTS: A 29-year-old Caucasian woman (patient 1) and a 23-year-old Caucasian woman (patient 2).Chief Complaints: Abnormal Pap tests with high risk HPV positivity.HISTORY OF PRESENT ILLNESS: PATIENT 1: In June 2014, this patient was diagnosed with atypical squamous cells of uncertain significance
PMID 26732782

Geographic variation in human papillomavirus-related oropharyngeal cancer: Data from four multinational randomized trials.

Mehanna H1, Franklin N2, Compton N3, Robinson M4, Powell N5, Biswas-Baldwin N6, Paleri V7, Hartley A8, Fresco L9, Al-Booz H10, Junor E11, El-Hariry I12, Roberts S13, Harrington K14, Ang KK15, Dunn J16, Woodman C13.
Head & neck.Head Neck.2016 Jan 8. doi: 10.1002/hed.24336. [Epub ahead of print]
BACKGROUND: There are variations in the proportions of head and neck cancers caused by the human papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.METHODS: We tested formalin-fixed paraffin-embedded diagnostic
PMID 26749143

Japanese Journal

子宮頸部明細胞腺癌と扁平上皮内癌が衝突癌状に共存した1例

木下英理子,黒瀬望,湊宏,野島孝之,中野万里子
日本臨床細胞学会雑誌 50(2), 132-133, 2011-03-22
NAID 10027955607

子宮体部から卵管にかけて表層進展した子宮頸部微小浸潤扁平上皮癌の1例

小林徳子,眞田照一郎,原田智子,佐竹立成,中島伸夫
日本臨床細胞学会雑誌 50(2), 125-131, 2011-03-22
NAID 10027955593

Related Pictures

Carcinoma in situ definition, breast, skin, cervix & bladder Squamous Cell Carcinoma In Situ of Penis Severe squamous dysplasia or Carcinoma in situ causing laryngeal leukoplakia | Iowa Bowen’s disease (Squamous cell carcinoma in situ) | Dermpedia Bowen's Disease / Squamous Cell Carcinoma in Situ Squamous carcinoma in situ - Larynx - MyPathologyReport.ca

★リンクテーブル★

リンク元	「ボーエン病」
関連記事	「sit」「in situ」「squamous」「situ」「cell」

「ボーエン病」

Bowen's disease
	Bowen's disease as seen under a microscope
Classification and external resources
Specialty	oncology, dermatology
ICD-10	D04 (ILDS D04.L10)
ICD-9-CM	230-234
ICD-O	8081/2
DiseasesDB	1569
eMedicine	derm/59
Patient UK	Bowen's disease
MeSH	D001913

　　[★]

英: Bowen's disease, Bowen disease
同: ボウエン病 Bowen病。表皮内有棘細胞癌 squamous cell carcinomain situ SCC in situ、precancerous dermatosis
ラ: morbus Bowen、有棘細胞

皮膚癌の分類

表皮系腫瘍

有棘細胞/基底細胞

脂漏性角化症 seborrheic keratosis

有棘細胞

基底細胞

基底細胞癌 basal cell carcinoma BCC

概念

有棘細胞癌の表皮内病変であり、前癌病変である。

疫学

高齢者に多い。

病因

ヒ素、パピローマウイルス(外陰の場合)

慢性ヒ素中毒　→　全身に多発

病理

表皮全層性に核異型の強い異型ケラチノサイトが密に乱雑に増殖
多核巨細胞(clumping cell)、異常角化細胞、異常核分裂像

皮膚所見

境界明瞭な直径数cm程度の紅褐色～黒褐色局面(NDE.395)

治療

外科的切除(第一選択)、抗腫瘍薬軟膏外用(5-FU、ブレオマイシン)、凍結療法

予後

放置により基底膜から真皮に進入し(有棘細胞癌)、転移する恐れがある。

参考

1. 写真 - 外観

http://4.bp.blogspot.com/_iCcaHsxVvTs/SG_W6-prdLI/AAAAAAAAAXs/ugS3CJJtQzo/s400/bowens%2Bdisease.gif

2. 病理写真

http://www.dermpedia.org/files/images/bowen_fig5.jpg

国試

101G009

「sit」

　　[★]

vi.

(過去-過去分詞sat)座る、位置する

関: lie、locate、location、loci、locus、map、position、rank、seat、situated、situation、stand、topo

「in situ」

　　[★]

生体内原位置で、原位置で、生体位で、切片上で、インサイツの

「squamous」

　　[★]

adj.

扁平上皮の, 鱗片状の

関: squamous epithelium

「situ」

　　[★]

(ラテン語)場所、位置

関: in situ

「cell」

　　[★] 細胞　　　　　　　

[Andrews-1] James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.

[2] J Invest Dermatol 2000 Sep;115(3):396-401

[3] Syed Imtiaz Ali Shah, Saeed Ahmed Sangi, Seraj Ahmed Abbasi: Bowen’s Disease: Pak J Ophthalmol 1998 Vol. 14, No. 1.p.37-38.

[Duncan2008-4] Duncan KO, Geisse JK, and DJ Leffell. (2008). "Ch. 113: Epithelial precancerous lesions". In Wolff K; et al. Fitzpatrick's Dermatology in General Medicine (7th ed.). New York: McGraw-Hill. ISBN 978-0-07-146690-5.

Bowen's disease
Bowen's disease as seen under a microscope
Classification and external resources
Specialty	oncology, dermatology
ICD-10	D04 (ILDS D04.L10)
ICD-9-CM	230-234
ICD-O	8081/2
DiseasesDB	1569
eMedicine	derm/59
Patient UK	Bowen's disease
MeSH	D001913

匿名

検索

案内

squamous cell carcinoma in situ