WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/04 03:08:32」(JST)

wiki en

Bowen's disease (BD) (also known as "squamous cell carcinoma in situ"^[1]^:655) is a neoplastic skin disease, it can be considered as an early stage or intraepidermal form of squamous cell carcinoma. It was named after John T. Bowen. Erythroplasia of Queyrat is a form of squamous cell carcinoma in situ arising on the glans or prepuce, possibly induced by HPV.^[2]

Causes

Causes of BD include solar damage, arsenic, immunosuppression (including AIDS), viral infection (human papillomavirus or HPV) and chronic skin injury and dermatoses.^[3]

Signs and symptoms

Bowen's disease typically presents as a gradually enlarging, well demarcated erythematous plaque with an irregular border and surface crusting or scaling. BD may occur at any age in adults but is rare before the age of 30 years - most patients are aged over 60. Any site may be affected, although involvement of palms or soles is uncommon. BD occurs predominantly in women (70-85% of cases). About 60-85% of patients have lesions on the lower leg, usually in previously or presently sun exposed areas of skin.

This is a persistent progressive non-elevated red scaly or crusted plaque which is due to an intraepidermal carcinoma and is potentially malignant. The lesions may occur anywhere on the skin surface or on mucosal surfaces. Freezing, cauterization or diathermy coagulation is often effective treatment.

Histology

Bowen's disease is essentially equivalent to squamous cell carcinoma in situ. Atypical squamous cells proliferate through the whole thickness of the epidermis. The entire tumor is confined to the epidermis and does not invade into the dermis. The cells in Bowen's are often highly atypical under the microscope, and may in fact look more unusual than the cells of some invasive squamous cell carcinomas.

Treatment

Photodynamic therapy (PDT), Cryotherapy (freezing) or local chemotherapy (with 5-fluorouracil) are favored by some clinicians over excision. Because the cells of Bowen's disease have not invaded the dermis, it has a much better prognosis than invasive squamous cell carcinoma. Outstanding results have been noted with the use of imiquimod for Bowen's disease of the skin, including the penis (erythroplasia of Queyrat), although Imiquimod is not FDA approved for the treatment of squamous cell carcinoma.

Additional images

References

^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
^ J Invest Dermatol 2000 Sep;115(3):396-401
^ Duncan KO, Geisse JK, and DJ Leffell. (2008). "Ch. 113: Epithelial precancerous lesions". In Wolff K, et al.. Fitzpatrick's Dermatology in General Medicine (7th ed.). New York: McGraw-Hill. ISBN 978-0-07-146690-5.

External links

Photo
Histological slide

UpToDate Contents

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1. 皮膚扁平上皮癌（SCC）の臨床的特徴および診断 clinical features and diagnosis of cutaneous squamous cell carcinoma scc
2. 皮膚扁平上皮癌の治療および予後 treatment and prognosis of cutaneous squamous cell carcinoma
3. 陰茎癌：臨床症状および診断 carcinoma of the penis clinical presentation and diagnosis
4. 顔面病変のダーモスコピー dermoscopy of facial lesions
5. 肛門扁平上皮内病変：診断、スクリーニング、予防、および治療 anal squamous intraepithelial lesions diagnosis screening prevention and treatment

English Journal

Periocular photodynamic therapy for squamous intra-epidermal carcinoma.

Casie Chetty N1, Hemmant B, Skellett AM.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):516-8. doi: 10.3109/09546634.2013.849793. Epub 2013 Nov 12.
OBJECTIVES: To evaluate the response of Metvix photodynamic therapy (PDT) for the treatment of periocular Bowen's disease.METHODS: Four patients with biopsy-proven Bowen' disease were treated with Metvix PDT between November 2010 and January 2012. A detailed description of the technique used is desc
PMID 24215518

Immunohistochemical study of cyclooxygenase-2 in skin tumors.

Amirnia M1, Babaie-Ghazani A, Fakhrjou A, Khodaeiani E, Alikhah H, Naghavi-behzad M, Zarrintan A.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Oct;25(5):380-7. doi: 10.3109/09546634.2012.674191. Epub 2012 Jun 5.
INTRODUCTION: Anti-cancerous effects of cyclooxygenase-2 (COX-2) inhibitors have been reported in different cancers. High expression of COX-2 has been demonstrated in various neoplasms such as colorectal, gastric, esophageal, breast, non-small cell lung cancers, and pre-neoplastic lesions such as co
PMID 22667343

Human diseases of the SSU processome.

Sondalle SB1, Baserga SJ2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1842(6):758-64. doi: 10.1016/j.bbadis.2013.11.004. Epub 2013 Nov 12.
Ribosomes are the cellular machines responsible for protein synthesis. Ribosome biogenesis, the production of ribosomes, is a complex process involving pre-ribosomal RNA (rRNA) cleavages and modifications as well as ribosomal protein assembly around the rRNAs to create the functional ribosome. The s
PMID 24240090

Japanese Journal

症例イミキモド5%クリーム外用が奏効したBowen病の1例

芝容平,崎山真幸,高橋英至 [他]
皮膚科の臨床 56(3), 450-453, 2014-03
NAID 40020024892

肛門部Bowen癌の1例～自験例を含めた本邦報告8例の集計～

大山莉奈,松信哲朗,鈴木英之,吉野雅則,三浦克洋,豊田哲鎬,中田亮輔,村木輝,清水貴夫,山際亮,渡辺昌則,内田英二
日本大腸肛門病学会雑誌 67(3), 183-187, 2014
… 部Bowen癌の1例を経験したので報告する．症例は57歳女性．肛門部の皮疹を訴え当院受診．肛門周囲皮膚に辺縁が明瞭な乳頭状隆起の集簇病変を認めた．生検では腫瘍細胞は表皮内に限局していたため，Bowen病の術前診断にて腫瘍局所切除術，有茎皮弁形成術，植皮術および人工肛門造設術を施行．病理組織学的診断では一部に基底層を越えた癌細胞の浸潤を認め，最終診断はBowen癌 …
NAID 130003394583

地域発症率からみた好酸球性膿疱性毛包炎における衛生仮説の検証

中島大毅,深町晶子,中村元信 [他],戸倉新樹
産業医科大学雑誌 35(3), 201-205, 2013-09-01
… EPF)は,Th2細胞の高IL-5発現を伴う疾患であり,Th1変調を導く治療が有効である.我々は北九州産業医大医療圏において,多発Bowen病患者が八幡東区,八幡西区,若松区に多く,戸畑区,小倉北区,小倉南区で比較的少ないことを報告し,同症が鉄鋼業や石炭関連産業を背景とするTh1変調地区に多いことを示してきた.同様にEPFの地域発症率を調べたところ,逆に戸畑区で高く,八幡東区で低いことを見出した.これはEPFが衛生仮説の代表的疾 …
NAID 110009657658

Related Pictures

★リンクテーブル★

リンク元	「ボーエン病」
関連記事	「disease」

「ボーエン病」

Bowen's disease
	Classification and external resources
	; Bowen's disease as seen under a microscope
ICD-10	D04 (ILDS D04.L10)
ICD-9	230-234
ICD-O:	8081/2
DiseasesDB	1569
eMedicine	derm/59
MeSH	D001913

　　[★]

英: Bowen's disease, Bowen disease
同: ボウエン病 Bowen病。表皮内有棘細胞癌 squamous cell carcinomain situ SCC in situ、precancerous dermatosis
ラ: morbus Bowen、有棘細胞

皮膚癌の分類

表皮系腫瘍

有棘細胞/基底細胞

脂漏性角化症 seborrheic keratosis

有棘細胞

基底細胞

基底細胞癌 basal cell carcinoma BCC

概念

有棘細胞癌の表皮内病変であり、前癌病変である。

疫学

高齢者に多い。

病因

ヒ素、パピローマウイルス(外陰の場合)

慢性ヒ素中毒　→　全身に多発

病理

表皮全層性に核異型の強い異型ケラチノサイトが密に乱雑に増殖
多核巨細胞(clumping cell)、異常角化細胞、異常核分裂像

皮膚所見

境界明瞭な直径数cm程度の紅褐色～黒褐色局面(NDE.395)

治療

外科的切除(第一選択)、抗腫瘍薬軟膏外用(5-FU、ブレオマイシン)、凍結療法

予後

放置により基底膜から真皮に進入し(有棘細胞癌)、転移する恐れがある。

参考

1. 写真 - 外観

http://4.bp.blogspot.com/_iCcaHsxVvTs/SG_W6-prdLI/AAAAAAAAAXs/ugS3CJJtQzo/s400/bowens%2Bdisease.gif

2. 病理写真

http://www.dermpedia.org/files/images/bowen_fig5.jpg

国試

101G009

「disease」

　　[★]

n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

something that is very wrong with people's attitudes, way of life or with society.

関: ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

注意

disease ≠ illness ≠ disorder

[Andrews-1] James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.

[2] J Invest Dermatol 2000 Sep;115(3):396-401

[Duncan2008-3] Duncan KO, Geisse JK, and DJ Leffell. (2008). "Ch. 113: Epithelial precancerous lesions". In Wolff K, et al.. Fitzpatrick's Dermatology in General Medicine (7th ed.). New York: McGraw-Hill. ISBN 978-0-07-146690-5.

匿名

検索

案内

案内

Bowen disease