可溶性インターロイキン2受容体
WordNet
- susceptible of solution or of being solved or explained; "the puzzle is soluble"
- (of a substance) capable of being dissolved in some solvent (usually water)
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
PrepTutorEJDIC
- 溶解できる / 解決できる
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- Increased soluble interleukin-2 receptor levels are related to somatic but not to cognitive-affective features in major depression.
- Euteneuer F, Schwarz MJ, Dannehl K, Hartung A, Westermann S, Rief W.SourceDivision of Clinical Psychology and Psychotherapy, Philipps University of Marburg, Marburg, Germany. Electronic address: frank.euteneuer@staff.uni-marburg.de.
- Brain, behavior, and immunity.Brain Behav Immun.2012 Nov;26(8):1244-8. doi: 10.1016/j.bbi.2012.06.007. Epub 2012 Jun 21.
- Cell-mediated immune activation may play a role in the pathogenesis of depression as indicated by findings of increased soluble tumor necrosis factor receptor (sTNF-R) levels and meta-analytic evidence for elevated soluble interleukin-2 receptor (sIL-2R) concentrations. However, little research has
- PMID 22728327
- Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure.
- Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH.Source*Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, Cincinnati, OH, United States †Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children's Hospital, Cincinnati, OH, United States ‡Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, United States §Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, ON, Canada ||Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States ¶Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States #Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States.
- Journal of pediatric gastroenterology and nutrition.J Pediatr Gastroenterol Nutr.2012 Oct 29. [Epub ahead of print]
- OBJECTIVES:: We sought to determine if markers of T cell immune activation, including soluble interleukin 2 receptor alpha (sIL2Rα) levels predict outcome in pediatric acute liver failure (PALF) and might target potential candidates for immunomodulatory therapy. METHODS:: We analyzed markers of imm
- PMID 23111765
Japanese Journal
- 血管内リンパ腫 (特集 稀な呼吸器疾患 : 診断と治療の最前線)
- Lymphoplasmacytic Lymphoma Presenting with Diarrhea and Joint Pain Which was Successfully Diagnosed by an MYD88 Mutation Analysis
- 症例 血清TARC値および血清可溶性IL-2R値が疾患活動性と相関した Non-episodic Angioedema with Eosinophilia の1例
Related Pictures
★リンクテーブル★
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- 英
- soluble interleukin-2 receptor sIL-2R
- 同
- 可溶性インターロイキン2レセプター
- 関
- IL-2
概念
- (2)(3)
- 免疫機構活性化の一指標
- 分子量70kdのp70(β鎖)と分子量55kdのTac抗原(α鎖)と呼ばれている2種類のサブユニットからなる蛋白
- 前者が休止期のリンパ球にも発現しているのに対して後者はリンパ球活性化の後に初めて見出される。
- 造血器悪性腫瘍、ウイルス感染、リウマチ等において上昇し、病勢を反映する指標として用いられており、臨床的には腫瘍マーカーとして用いられている。
- リンパ球活性化状態においてTac抗原が末梢血中に可溶性の形でも存在することが明らかになり、可溶性インターロイキン2受容体と名付けられた。
- sIL-2RはIL-2との結合性を保持することから、生体の免疫調節にも関与していると推定されている。
測定方法
基準値
- (2)
- (3)
- 122~496 U/ml(平成21年10月1日より)
- 190~650 U/ml(平成21年9月30日まで)
鑑別
LAB DATA2017-2018
基準値:220-530U/ml
臨床検査ガイド2015
基準値:122-496
- 497-1000:悪性リンパ腫。成人T細胞性白血病、血球貪食症候群
- 否定できない疾患:慢性骨髄性白血病の急性転化、自己免疫疾患、肝炎、肺結核、サルコイドーシス、間質性肺炎、臓器移植後、固形腫瘍
異常値を示す疾患
参考
- 1. Plasma soluble interleukin-2 receptor (sIL-2R) levels in patients with acute leukemia.
- http://www.ncbi.nlm.nih.gov/pubmed/15648782
- 2. 細胞性免疫検査 細胞機能検査 可溶性インターロイキン-2レセプター
- http://data.medience.co.jp/compendium/main.asp?field=07&m_class=02&s_class=0011
- http://www.okayama-u.ac.jp/user/hos/kensa/hotai/ir-2r.htm
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- 関
- lytic、solubility、solubilizing
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インターロイキン IL
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インターロイキン IL