ホスホジエステラーゼ5阻害薬
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- 1. 男性性機能不全の治療treatment of male sexual dysfunction [show details]
… longer duration of action. Avanafil and orodispersible (ODT) vardenafil have a more rapid onset . PDE5 inhibitors are contraindicated in men taking nitrates and should be used cautiously in men receiving …
- 2. 不安定狭心症および非ST上昇型心筋梗塞の非急性期マネージメントの概要overview of the non acute management of unstable angina and non st elevation myocardial infarction [show details]
…patients with recurrent ischemia, hypertension, or heart failure. The phosphodiesterase-5 inhibitors (sildenafil, vardenafil, and tadalafil) are contraindicated in patients taking nitrates because of the potential …
- 3. 心血管疾患患者における性的活動sexual activity in patients with cardiovascular disease [show details]
…important issue is that phosphodiesterase-5 (PDE-5) inhibitors should not be used with nitrates in any form . The PDE-5 inhibitors sildenafil, vardenafil, and tadalafil are widely used in the treatment of erectile …
- 4. 成人における肺動脈性肺高血圧症の治療（グループ 1）：肺高血圧症に特異的な治療treatment of pulmonary arterial hypertension group 1 in adults pulmonary hypertension specific therapy [show details]
… prefer IV epoprostenol added to a PDE5I (eg, sildenafil, tadalafil). Several combinations have been shown to be beneficial in patients with PAH: Sildenafil added to epoprostenol – One trial randomly assigned …
- 5. 男性の癌生存者における性機能不全症の概要overview of sexual dysfunction in male cancer survivors [show details]
… Much of the data regarding the role of PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil) in cancer come from studies in men with prostate cancer. Overall, the data support the use of these medications …
English Journal
- Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes.
- Itoga A, Zha X, Nagase K, Aoki Y, Ito H, Yokoyama O.
- BMJ open diabetes research & care. 2020 May;8(1).
- Sexual dysfunction is a common complication in men with type 2 diabetes and is often refractory to treatment. This study investigated the long-term influence of the phosphodiesterase 5 inhibitor (PDE5I) tadalafil on the level of sex hormones and sexual function in male Otsuka Long-Evans Tokushima Fa
- PMID 32371530
- Phosphodiesterase Type-5 Inhibitor Prescription Patterns in the United States Among Men With Erectile Dysfunction: An Update.
- Mulhall JP, Chopra I, Patel D, Hassan TA, Tang WY.
- The journal of sexual medicine. 2020 May;17(5)941-948.
- While phosphodiesterase type-5 inhibitors (PDE5Is) are highly effective for the treatment of erectile dysfunction (ED) and well tolerated, updated data on prescription patterns have been limited in real-world settings. To describe men in the United States who are prescribed PDE5Is for ED treatment a
- PMID 32144034
- Sildenafil Reduces Expression and Release of IL-6 and IL-8 Induced by Reactive Oxygen Species in Systemic Sclerosis Fibroblasts.
- Di Luigi L, Sgrò P, Duranti G, Sabatini S, Caporossi D, Del Galdo F, Dimauro I, Antinozzi C.
- International journal of molecular sciences. 2020 Apr;21(9).
- Oxidative stress linked to vascular damage plays an important role in the pathogenesis of systemic sclerosis (SSc). Indeed, vascular damage at nailfold capillaroscopy in patients with Raynaud's Phenomenon (RP) is a major risk factor for the development of SSc together with the presence of specific a
- PMID 32365773
Japanese Journal
- Identification of Descarbonsildenafil in an Adulterated Dietary Supplement and Evaluation of Its Inhibitory Activity for Phosphodiesterase Type 5 (PDE5)
- ICHIKAWA-KAJI Yoko,NAKAJIMA Junichi,KIKKAWA Shoko,ISHIZAWA Fujio,NISHIYAMAm Rei,KISHIMOTO Kiyoko,UEMURA Nozomi,SATOH Miki,SUZUKI Jin,INOMATA Akiko,NAKAE Dai,Isao@AZUMAYA,HONDA Katsuya,MORIYASU Takako
- 食品衛生学雑誌 = Food hygiene and safety science 61(1), 34-40, 2020-02
- NAID 40022178526
- 脊髄損傷ラットにおけるアドレナリンα<sub>1A/D</sub>受容体遮断薬およびPDE-5阻害薬の膀胱リモデリングに及ぼす効果
- 嘉手川 豪心,菅谷 公男,吉村 直樹
- 日本薬理学雑誌 155(1), 10-15, 2020
- … を実施し，1，2，4，8，12週目に摘出膀胱組織内の虚血マーカー（HIF-1α：hypoxia inducible factor 1α，VEGF：vascular endothelial growth factor）および線維化マーカー（TGF-β1：transforming growth factor β1，collagen type 1，collagen type 3）のmRNA発現量と，コラーゲンおよびエラスチン含有量を解析した．Vehicle SCI群ではSCI早期から排尿筋括約筋協調不全（DSD：detrusor-sphincter dyssynergia）パターンを呈し，排尿効率が低下した．TGF …
- NAID 130007778969
- 高血圧における男性機能 (特集 腎泌尿器における高血圧最前線)
- 白井 雅人,辻村 晃
- 腎臓内科・泌尿器科 = Nephrology & urology 10(1), 58-61, 2019-07
- NAID 40021979923
Related Links
- PDE 5 inhibitors stop a particular enzyme (phosphodiesterase type 5 [PDE5]), found in blood vessel walls, from working properly. PDE5 helps control blood flow to the pulmonary arteries. By stopping PDE5 from working, PDE 5
- Chronic low dosing of phosphodiesterase type 5 inhibitor for erectile dysfunction. Korean J Urol. 2012; 53 (6):377–385. [PMC free article] [] [Google Scholar] 23. Porst H, Rajfer J, Casabe A, et al. Long-term safety and efficacy of 5 ...
- The phosphodiesterase type 5 (PDE5) inhibitors cause vasodilation in the penis and lung by blocking the breakdown of cyclic guanosine monophosphate (cGMP) which results in prolongation of the action of mediators of vasodilation including nitric oxide (NO). The type-5 phosphodiesterases are isoforms of this enzyme that are found primarily in the corpus cavernosum of penis and vasculature of the ...
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- 英
- phosphodiesterase type 5 inhibitor, phosphodiesterase-5 inhibitor
- 関
- ホスホジエステラーゼ5、ホスホジエステラーゼ
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- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
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- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
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- 関
- blocker、depressant、suppressant
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- 関
- form、mode、pattern、type
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