phosphodiesterase-5 inhibitor

ホスホジエステラーゼ5阻害薬

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• 1. 男性性機能不全の治療treatment of male sexual dysfunction [show details]
  … longer duration of action. Avanafil and orodispersible (ODT) vardenafil have a more rapid onset . PDE5 inhibitors are contraindicated in men taking nitrates and should be used cautiously in men receiving …
• 2. 心血管疾患患者における性的活動sexual activity in patients with cardiovascular disease [show details]
  …important issue is that phosphodiesterase-5 (PDE-5) inhibitors should not be used with nitrates in any form . The PDE-5 inhibitors sildenafil, vardenafil, and tadalafil are widely used in the treatment of erectile …
• 3. 成人における肺動脈性肺高血圧症の治療（グループ 1）：肺高血圧症に特異的な治療treatment of pulmonary arterial hypertension group 1 in adults pulmonary hypertension specific therapy [show details]
  … macitentan), nitric oxide (NO)-guanosine monophosphate (cGMP) enhancers (phosphodiesterase 5 inhibitors [PDE5Is; sildenafil, tadalafil]), or rarely, calcium channel blockers (CCBs; nifedipine, diltiazem) …
• 4. 不安定狭心症および非ST上昇型心筋梗塞の非急性期マネージメントの概要overview of the non acute management of unstable angina and non st elevation myocardial infarction [show details]
  …patients with recurrent ischemia, hypertension, or heart failure. The phosphodiesterase-5 inhibitors (sildenafil, vardenafil, and tadalafil) are contraindicated in patients taking nitrates because of the potential …
• 5. 男性の癌生存者における性機能不全症の概要overview of sexual dysfunction in male cancer survivors [show details]
  … Much of the data regarding the role of PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil) in cancer come from studies in men with prostate cancer. Overall, the data support the use of these medications …

English Journal

• Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.

• Pal S, Rashid M, Singh SK, Porwal K, Singh P, Mohamed R, Gayen JR, Wahajuddin M, Chattopadhyay N.
• Bone. 2020 Jun;135()115305.
• Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides and thereby regulate diverse cellular functions. The reports on the skeletal effects of PDE inhibitors are conflicting. Here, we screened 17 clinically used non-xanthine PDE inhibitors (selective and non-selective) using mouse calvarial osteobla
• PMID 32126313

• Combination Therapy with Alpha-blocker and Phosphodiesterase-5 Inhibitor for Improving Lower Urinary Tract Symptoms and Erectile Dysfunction in Comparison with Monotherapy: A Systematic Review and Meta-analysis.

• Kallidonis P, Adamou C, Kotsiris D, Ntasiotis P, Verze P, Athanasopoulos A, .
• European urology focus. 2020 May;6(3)537-558.
• The effects of combination therapy consisted of an α-blocker and a phosphodiesterase-5 inhibitor (PDE5I) for the treatment of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). To systematically investigate the efficacy and safety of combination therapy in comparison with monotherap
• PMID 31133414

• Phosphodiesterase-5 Inhibitors for Premature Ejaculation: Systematic Review and Meta-Analysis of Placebo-Controlled Trials.

• Zhang X, Chi N, Sun M, Shan Z, Zhang Y, Cui Y.
• American journal of men's health.  ;14(3)1557988320916406.
• The purpose of this analysis is to assess the efficacy and safety of phosphodiesterase-5 inhibitors (PDE5Is) for the treatment of premature ejaculation (PE). A comprehensive search was performed to ascertain from trials about PDE5Is for the treatment of PE and compare the results, including intravag
• PMID 32375542

Japanese Journal

• PDE4およびPDE5阻害剤の投与および共投与はデュシェンヌ型筋ジストロフィーマウスの病態を線維化および炎症を抑制することにより改善する

• 仁尾 泰徳,田中 将之,廣實 慶彦,村木 暢,松尾 孝徳,大川原 賦,波佐間 正聡
• 日本薬理学会年会要旨集 93(0), 2-O-070, 2020
• … Phosphodiesterase 4 (PDE4) inhibitors have exhibited antifibrotic effects in human and animal models. … In this study,we showed beneficial effects of the PDE4 inhibitor piclamilast in the DMD mdx mouse. … The PDE5 inhibitors sildenafil and tadalafil ameliorated functional muscle ischemia in boys with DMD, and sildenafil reversed cardiac dysfunction in the mdx mouse. …
• NAID 130007811564

• ホスホジエステラーゼ5阻害薬tadalafilは糸球体濾過バリアを保護し、腎機能の低下を抑制する　－CKD、ネフローゼ症候群モデルを用いた検討－

• 冨田 なつみ,堀田 祐志,内木 綾,吉川 麻優,片岡 智哉,髙橋 智,木村 和哲
• 日本薬理学会年会要旨集 93(0), 1-SS-45, 2020
• … Phosphodiesterase (PDE) 5 inhibitor is reported to have renoprotective effects, however, its mechanisms are unknown. … In this study, we investigated the effects of a PDE5 inhibitor, tadalafil, on two renal dysfunction model. …
• NAID 130007811382

• 臨床研究から明らかになった排尿障害治療薬の最新の知見

• 松川 宜久,舟橋 康人,後藤 百万
• 日本薬理学会年会要旨集 92(0), 3-S25-4, 2019
• … <p>Current guidelines for the treatment of benign prostatic hyperplasia (BPH) in several countries recommend the use of α₁-adrenoceptor antagonists (α1-blockers) or 5-alpha-reductase inhibitors (5ARIs), or phosphodiesterase 5 (PDE5) inhibitors for patients with lower urinary tract symptoms (LUTS) suggestive of BPH (LUTS/BPH). …
• NAID 130007813377

Related Links

• Phosphodiesterase 5 inhibitors | PHA

PDE 5 inhibitors are taken as nearly always tablets. An injection of sildenafil is available for short-term use when patients aren’t able to eat or drink, for example when having an operation. How do phosphodiesterase 5 inhibitors

• What are the Phosphodiesterase 5 Inhibitors? - ED Patients

Phosphodiesterase-5 Inhibitors (PDE5Is) in Help of Men with Erectile Dysfunction (ED) What are the Phosphodiesterase 5 inhibitors (PDE5Is)?You will see these a lot in the topic of ED. When it comes toED treatment, PDE5Is have a privileged place and role among all recommended options as FDA approved medicinal products.

• Phosphodiesterase inhibitors – Knowledge for medical ...

Phosphodiesterase inhibitors (PDE inhibitors) are a class of drugs that inhibit phosphodiesterase enzymes (). PDEs normally break off phosphate groups and decrease cAMP or cGMP in target cells . PDE inhibitors are classified according to which enzyme(s) they act upon as nonspecific, PDE5, PDE4, and PDE3 inhibitors .

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★リンクテーブル★

リンク元	「ホスホジエステラーゼ5阻害薬」
関連記事	「inhibit」「inhibitor」「phosphodiesterase 5」「phosphodiesterase」「phosphodiesterases」

「ホスホジエステラーゼ5阻害薬」

　　[★]

英

phosphodiesterase type 5 inhibitor, phosphodiesterase-5 inhibitor

関

ホスホジエステラーゼ5、ホスホジエステラーゼ

「inhibit」

　　[★]

• v.

• 抑制する、阻害する、阻止する

関

abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

　 　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「phosphodiesterase 5」

　　[★]

ホスホジエステラーゼ5

関

PDE5、type 5 cyclic nucleotide phosphodiesterase

「phosphodiesterase」

　　[★] ホスホジエステラーゼ PDE

「phosphodiesterases」

　　[★] ホスホジエステラーゼ