関: IRF

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
an official responsible for control and supervision of a particular activity or area of public interest
an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
取り締まり人;調整者 / 調整装置
インターフェロン(ウイルス増殖抑制物質)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/06 07:17:04」(JST)

wiki en

Interferon regulatory factors are proteins which regulate transcription of interferons (see regulation of gene expression).^[1]

They are used in the JAK-STAT signaling pathway.^[2]

Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence (ICS), which is located upstream of the interferon genes.^[3] The remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein.^[3]

Genes

IRF1
IRF2
IRF3
IRF4
IRF5
IRF6
IRF7
IRF8
IRF9

References

^ Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie. 89 (6–7): 744–53. doi:10.1016/j.biochi.2007.01.014. PMC 2139905 . PMID 17399883.
^ Tsuneya Ikezu; Howard E. Gendelman (2008). Neuroimmune Pharmacology. Springer. pp. 213–. ISBN 978-0-387-72572-7. Retrieved 28 November 2010.
^ ^a ^b Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054.

External links

Interferon regulatory factors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the public domain Pfam and InterPro IPR001346

This protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
2. リードスタンバーグ細胞およびホジキンリンパ腫の病因 the reed sternberg cell and the pathogenesis of hodgkin lymphoma
3. 全身性硬化症（強皮症）の危険因子および考えられる原因 risk factors for and possible causes of systemic sclerosis scleroderma
4. 抗酸菌易感染性を示すメンデル型遺伝性疾患：概要 mendelian susceptibility to mycobacterial diseases an overview
5. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy

English Journal

Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells.

Sisirak V, Vey N, Goutagny N, Renaudineau S, Malfroy M, Thys S, Treilleux I, Labidi-Galy SI, Bachelot T, Dezutter-Dambuyant C, Ménétrier-Caux C, Blay JY, Caux C, Bendriss-Vermare N.SourceUniversité de Lyon, Lyon, France; Université Lyon 1, ISPB, Lyon, France; INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Department of Immunity, Virus, and Microenvironment, Lyon, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Department of Immunity, Virus, and Microenvironment, Lyon, France; LabEx DEVweCAN, Lyon, France.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Aug 1;133(3):771-8. doi: 10.1002/ijc.28072. Epub 2013 Mar 8.
We previously reported that plasmacytoid dendritic cells (pDCs) infiltrating breast tumors are impaired for their interferon-α (IFN-α) production, resulting in local regulatory T cells amplification. We designed our study to decipher molecular mechanisms of such functional defect of tumor-associat
PMID 23389942

Scoparone attenuates d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice.

Kang JW, Kim DW, Choi JS, Kim YS, Lee SM.SourceSchool of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2013 Jul;57:132-9. doi: 10.1016/j.fct.2013.03.016. Epub 2013 Mar 25.
The purpose of this study was to investigate the protective effects and molecular mechanisms of scoparone on d-galactosamine (d-GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure (FHF) in mice. FHF was induced in mice by intraperitoneal injection of d-GalN (800mg/kg)/LPS (40μg/kg). Mi
PMID 23535186

Integrated analysis of innate, Th1, th2, th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F.SourceInstitute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, United Kingdom.
The Journal of infectious diseases.J Infect Dis.2013 Jul;208(1):159-69. doi: 10.1093/infdis/jis524. Epub 2012 Oct 8.
Background. Schistosomiasis elicits cross-regulatory immune responses, but it is unclear how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters immune polarization and whether post-treatme
PMID 23045617

Japanese Journal

Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.

Shindo Hisakazu,Yasui Kiyoshi,Yamamoto Kazuo,Honma Kiri,Yui Katsuyuki,Kohno Tomoko,Ma Yuhua,Chua Koon Jiew,Kubo Yoshinao,Aihara Hitoshi,Ito Takashi,Nagayasu Takeshi,Matsuyama Toshifumi,Hayashi Hideki
Cytokine 56(3), 564-572, 2011-12
… Interferon regulatory factor (IRF)-4 is a member of the IRF transcription factor family, whose expression is primarily restricted to lymphoid and myeloid cells. … In T-cells, IRF-4 expression is induced by T-cell receptor (TCR) cross-linking or treatment with phorbol-12-myristate-13-acetate (PMA)/Ionomycin, and IRF-4 is thought to be a critical factor for various functions of T-cells. …
NAID 120003659758

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

Hayashi Hideki,Kohno Tomoko,Yasui Kiyoshi,Murota Hiroyuki,Kimura Tohru,Duncan Gordon S,Nakashima Tomoki,Yamamoto Kazuo,Katayama Ichiro,Ma Yuhua,Chua Koon Jiew,Suematsu Takashi,Shimokawa Isao,Akira Shizuo,Kubo Yoshinao,Mak Tak Wah,Matsuyama Toshifumi
Proceedings of the National Academy of Sciences of the United States of America 108(46), 18766-18771, 2011-11-15
… This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1116273108/-/DCSupplemental.Mice deficient for interferon regulatory factor (Irf)2 (Irf2(-/-) mice) exhibit immunological abnormalities and cannot survive lymphocytic choriomeningitis virus infection. …
NAID 120003659756

「IRF」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Interferon regulatory factor transcription factor
	interferon regulatory factor-2 dna binding domain, nmr, minimized average structure
Identifiers
Symbol	IRF
Pfam	PF00605
InterPro	IPR001346
SCOP	1if1
SUPERFAMILY	1if1
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

　　[★]

インターフェロン調節因子

関: interferon regulatory factor

「インターフェロン調節因子」

　　[★]

英: interferon regulatory factor、IRF

「interferon regulatory factor-1」

　　[★] インターフェロン調節因子-1

関: IRF-1

「interferon regulatory factor-2」

　　[★] インターフェロン調節因子-2

関: IRF-2

「interferon regulatory factor-3」

　　[★] インターフェロン調節因子-3

関: IRF-3

「interferon regulatory factor-7」

　　[★] インターフェロン調節因子-7

関: IRF-7

「fact」

　　[★]

n.

事実、現状、実際、実態

関: actual、actually、in fact、in practice、indeed、practically

「factor」

　　[★]

n.

因子、要因、要素、ファクター

関: element、elementary、factorial、parameter

「regulatory」

　　[★]

adj.

制御の、調節性の、制御的な、(法律)規制の

関: control、modulatory、regulate、regulation

「regulator」

　　[★]

n.

制御因子、レギュレーター

関: regulatory factor

「regulatory factor」

　　[★]

制御因子、調節因子

関: controlling factor、regulator

[pmid17399883-1] Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie. 89 (6–7): 744–53. doi:10.1016/j.biochi.2007.01.014. PMC 2139905 . PMID 17399883.

[IkezuGendelman2008-2] Tsuneya Ikezu; Howard E. Gendelman (2008). Neuroimmune Pharmacology. Springer. pp. 213–. ISBN 978-0-387-72572-7. Retrieved 28 November 2010.

[pmid1460054-3] Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054.

リンク元	「IRF」「インターフェロン調節因子」
拡張検索	「interferon regulatory factor-1」「interferon regulatory factor-2」「interferon regulatory factor-3」「interferon regulatory factor-7」
関連記事	「fact」「factor」「regulatory」「regulator」「regulatory factor」

匿名

検索

案内

案内

interferon regulatory factor