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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/12 16:33:31」(JST)

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Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.^[1]

Function

IRF3 is a member of the interferon regulatory transcription factor (IRF) family.^[1] IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites.^[2] IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.^[3] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.^[4]

IRF3 plays an important role in the innate immune system's response to viral infection.^[5] Aggregated MAVS have been found to activate IRF3 dimerization.^[6]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

Interactions

IRF3 has been shown to interact with IRF7.^[7]

References

^ ^a ^b Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y et al. (1999). "Triggering the interferon response: the role of IRF-3 transcription factor". J. Interferon Cytokine Res. 19 (1): 1–13. doi:10.1089/107999099314360. PMID 10048763.
^ Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J (Feb 1999). "Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription". Mol Cell Biol 19 (2): 959–66. PMC 116027. PMID 9891032.
^ Yoneyama M, Suhara W, Fujita T (2002). "Control of IRF-3 activation by phosphorylation". J. Interferon Cytokine Res. 22 (1): 73–6. doi:10.1089/107999002753452674. PMID 11846977.
^ "Entrez Gene: IRF3 interferon regulatory factor 3".
^ Collins SE, Noyce RS, Mossman KL (Feb 2004). "Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication". J Virol 78 (4): 1706–17. doi:10.1128/JVI.78.4.1706-1717.2004. PMC 369475. PMID 14747536.
^ Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (Aug 5, 2011). "MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response". Cell 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231.
^ Au WC, Yeow WS, Pitha PM (Feb 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. doi:10.1006/viro.2000.0782. PMID 11162841.

External links

Interferon Regulatory Factor-3 at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook IRF3

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English Journal

The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2.

Chistiakov DA1, Myasoedova VA2, Revin VV3, Orekhov AN2, Bobryshev YV4.
Immunobiology.Immunobiology.2018 Jan;223(1):101-111. doi: 10.1016/j.imbio.2017.10.005. Epub 2017 Oct 5.
PMID 29032836

MiR-525-3p mediates antiviral defense to rotavirus infection by targeting nonstructural protein 1.

Tian Z1, Zhang J1, He H1, Li J2, Wu Y3, Shen Z4.
Biochimica et biophysica acta.Biochim Biophys Acta.2017 Dec;1863(12):3212-3225. doi: 10.1016/j.bbadis.2017.09.003. Epub 2017 Sep 7.
PMID 28890396

Endoplasmic Reticulum Transmembrane Proteins ZDHHC1 and STING Both Act as Direct Adaptors for IRF3 Activation in Teleost.

Xu X1, Li M1, Wu Z1, Wang H1, Wang L1, Huang K1, Liu X1, Hou Q1, Lin G1, Hu C2.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2017 Nov 15;199(10):3623-3633. doi: 10.4049/jimmunol.1700750. Epub 2017 Oct 18.
PMID 29046345

Japanese Journal

Virology : Analysis of a pair of END⁺ and END⁻ viruses derived from the same bovine viral diarrhea virus stock reveals the amino acid determinants in N[pro] responsible for inhibition of type I interferon production

KOZASA Takashi,ABE Yuri,MITSUHASHI Kazuya [他],TAMURA Tomokazu,AOKI Hiroshi,ISHIMARU Masatoshi,NAKAMURA Shigeyuki,OKAMATSU Masatoshi,KIDA Hiroshi,SAKODA Yoshihiro
Journal of Veterinary Medical Science 77(5), 511-518, 2015
… The Exaltation of Newcastle disease virus (END) phenomenon is induced by the inhibition of type I interferon in pestivirus-infected cells in vitro, via proteasomal degradation of cellular interferon regulatory factor (IRF)-3 with the property of the viral autoprotease protein N-pro. …
NAID 130005071888

Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3

Homma Takujiro,Ishibashi Daisuke,Nakagaki Takehiro,Fuse Takayuki,Sano Kazunori,Satoh Katsuya,Atarashi Ryuichiro,Nishida Noriyuki
Scientific Reports 4, 6006, 2014-08-08
… As a prompt response against invasion of various viruses, interferon regulatory factor-3 (IRF-3) is initially phosphorylated to become activated and upregulates mainly Type I Interferons (IFN-I) in most cell types. … We previously reported that IRF-3-dependent host innate immune responses partially interfere in infection of prions. …
NAID 120005477044

MAVS-dependent IRF3/7 bypass of interferon p-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells

Takaki Hiromi,Honda Kenya,Atarashi Koji,Kobayashi Fukiko,Ebihara Takashi,Oshiumi Hiroyuki,Matsumoto Misako,Shingai Masashi,Seya Tsukasa
Molecular immunology 57(2), 100-109, 2014-02
… RNA virus infection usually allows cells to generate double-stranded RNA and induce activation of IFN regulatory factor (IRF) 3/7 transcription factors, leading to the production of type I IFN through the retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5)-mitochondrial antiviral signaling protein (MAVS) pathway. … In mouse experimental BMDCs models, we found CD150Tg/Mavs(-/-)BMDCs, but not CD150Tg/Irf3(-/-)/Irf7-/-BMDCs, permissive to MV. …
NAID 120005372324

「interferon regulatory factor-3」

Interferon regulatory factor 3
	PDB rendering based on 1j2f.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 3QU6
Identifiers
Symbol	IRF3
External IDs	OMIM: 603734 MGI: 1859179 HomoloGene: 1208 GeneCards: IRF3 Gene
Gene ontology
Molecular function	• regulatory region DNA binding; • DNA binding; • sequence-specific DNA binding transcription factor activity; • transcription cofactor activity; • protein binding; • identical protein binding; • protein homodimerization activity;
Cellular component	• nucleus; • nucleoplasm; • cytoplasm; • cytosol;
Biological process	• toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • regulation of transcription, DNA-templated; • transcription from RNA polymerase II promoter; • apoptotic process; • cellular response to DNA damage stimulus; • viral process; • cytokine-mediated signaling pathway; • lipopolysaccharide-mediated signaling pathway; • negative regulation of type I interferon production; • positive regulation of type I interferon production; • positive regulation of interferon-alpha production; • positive regulation of interferon-beta production; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • MDA-5 signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • response to exogenous dsRNA; • innate immune response; • type I interferon biosynthetic process; • positive regulation of cytokine secretion; • defense response to virus; • interferon-gamma-mediated signaling pathway; • type I interferon signaling pathway; • positive regulation of type I interferon-mediated signaling pathway; • cellular response to dsRNA; • macrophage apoptotic process; • programmed necrotic cell death;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;