関: IRF-3

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
an official responsible for control and supervision of a particular activity or area of public interest
an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
取り締まり人;調整者 / 調整装置
インターフェロン(ウイルス増殖抑制物質)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/24 18:14:21」(JST)

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Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.^[1]

Function

IRF3 is a member of the interferon regulatory transcription factor (IRF) family.^[1] IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites.^[2] IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.^[3] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.^[4]

IRF3 plays an important role in the innate immune system's response to viral infection.^[5] Aggregated MAVS have been found to activate IRF3 dimerization.^[6]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

Interactions

IRF3 has been shown to interact with IRF7.^[7]

References

^ ^a ^b Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R (1999). "Triggering the interferon response: the role of IRF-3 transcription factor". J. Interferon Cytokine Res. 19 (1): 1–13. doi:10.1089/107999099314360. PMID 10048763.
^ Lin, R.; Heylbroeck, C.; Genin, P.; Pitha, PM.; Hiscott, J. (Feb 1999). "Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription". Mol Cell Biol 19 (2): 959–66. PMC 116027. PMID 9891032.
^ Yoneyama M, Suhara W, Fujita T (2002). "Control of IRF-3 activation by phosphorylation". J. Interferon Cytokine Res. 22 (1): 73–6. doi:10.1089/107999002753452674. PMID 11846977.
^ "Entrez Gene: IRF3 interferon regulatory factor 3".
^ Collins, SE.; Noyce, RS.; Mossman, KL. (Feb 2004). "Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication". J Virol 78 (4): 1706–17. doi:10.1128/JVI.78.4.1706-1717.2004. PMC 369475. PMID 14747536.
^ Hou, F; Sun, L; Zheng, H; Skaug, B; Jiang, QX; Chen, ZJ (Aug 5, 2011). "MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response". Cell 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231.
^ Au, W C; Yeow W S; Pitha P M (Feb 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology (United States) 280 (2): 273–82. doi:10.1006/viro.2000.0782. ISSN 0042-6822. PMID 11162841.

External links

Interferon Regulatory Factor-3 at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook IRF3

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UpToDate Contents

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1. 抗酸菌易感染性を示すメンデル型遺伝性疾患（Mendelian
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diseases：MSMD） mendelian susceptibility to mycobacterial diseases msmd
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4. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
5. 抗Ro/SSA抗体および抗La/SSB抗体の抗原抗体系 the anti ro ssa and anti la ssb antigen antibody systems

English Journal

Mycoplasma ovipneumoniae induces inflammatory response in sheep airway epithelial cells via a MyD88-dependent TLR signaling pathway.

Xue D1, Ma Y1, Li M1, Li Y1, Luo H1, Liu X1, Wang Y2.
Veterinary immunology and immunopathology.Vet Immunol Immunopathol.2015 Jan 15;163(1-2):57-66. doi: 10.1016/j.vetimm.2014.11.008. Epub 2014 Nov 20.
Mycoplasma ovipneumoniae (M. ovipneumoniae) is a bacterium that specifically infects sheep and goat and causes ovine infectious pleuropneumonia. In an effort to understand the pathogen-host interaction between the M. ovipneumoniae and airway epithelial cells, we investigated the host inflammatory re
PMID 25440083

Suppressive effects of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine on the Toll-like receptor signaling pathways.

Ahn SI1, Lim SJ2, Gu GJ1, Hong CY2, Kim JS1, Jeong HJ3, Koh KO3, Mang JY3, Kim DY3, Youn HS4.
International immunopharmacology.Int Immunopharmacol.2015 Jan;24(1):36-41. doi: 10.1016/j.intimp.2014.10.033. Epub 2014 Nov 10.
When various pathogens invade a host, toll-like receptors (TLRs) play a significant role in recognizing the pathogen-associated molecular patterns carried by the pathogens to induce innate immune reaction, followed by acquired immunity reaction. TLRs have two downstream signaling pathways, the myelo
PMID 25445967

Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.

Yang Y1, Lee J2, Rhee MH3, Yu T1, Baek KS1, Sung NY1, Kim Y1, Yoon K1, Kim JH1, Kwak YS4, Hong S1, Kim JH5, Cho JY1.
Journal of ginseng research.J Ginseng Res.2015 Jan;39(1):61-8. doi: 10.1016/j.jgr.2014.06.002. Epub 2014 Jun 19.
BACKGROUND: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated an
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Japanese Journal

Virology : Analysis of a pair of END⁺ and END⁻ viruses derived from the same bovine viral diarrhea virus stock reveals the amino acid determinants in N[pro] responsible for inhibition of type I interferon production

KOZASA Takashi,ABE Yuri,MITSUHASHI Kazuya [他],TAMURA Tomokazu,AOKI Hiroshi,ISHIMARU Masatoshi,NAKAMURA Shigeyuki,OKAMATSU Masatoshi,KIDA Hiroshi,SAKODA Yoshihiro
Journal of Veterinary Medical Science 77(5), 511-518, 2015
… The Exaltation of Newcastle disease virus (END) phenomenon is induced by the inhibition of type I interferon in pestivirus-infected cells in vitro, via proteasomal degradation of cellular interferon regulatory factor (IRF)-3 with the property of the viral autoprotease protein Npro. …
NAID 130005071888

Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3

Homma Takujiro,Ishibashi Daisuke,Nakagaki Takehiro,Fuse Takayuki,Sano Kazunori,Satoh Katsuya,Atarashi Ryuichiro,Nishida Noriyuki
Scientific Reports 4, 6006, 2014-08-08
… As a prompt response against invasion of various viruses, interferon regulatory factor-3 (IRF-3) is initially phosphorylated to become activated and upregulates mainly Type I Interferons (IFN-I) in most cell types. … We previously reported that IRF-3-dependent host innate immune responses partially interfere in infection of prions. …
NAID 120005477044

A new adjuvant delivery system 'cyclic di-GMP/YSK05 liposome' for cancer immunotherapy

Miyabe Hiroko,Hyodo Mamoru,Nakamura Takashi,Sato Yusuke,Hayakawa Yoshihiro,Harashima Hideyoshi
Journal of Controlled Release 184, 20-27, 2014-06-28
… It is thought that c-di-GMP is recognized by ATP dependent RNA helicase (DDX41) in the cytosol, forms a complex with the Stimulator of interferon genes protein (STING), triggers a signal via the tank binding kinase 1-interferon regulatory factor 3 (TBK1-IRF3) pathway and induces the production of type I interferons. …
NAID 120005512017

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★リンクテーブル★

リンク元	「IRF-3」「インターフェロン調節因子-3」
関連記事	「fact」「factor」「regulatory」「regulator」「regulatory factor」

「IRF-3」

Interferon regulatory factor 3
	; PDB rendering based on 1j2f.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 3QU6
Identifiers
Symbol	IRF3
External IDs	OMIM: 603734 MGI: 1859179 HomoloGene: 1208 GeneCards: IRF3 Gene
Gene ontology
Molecular function	• regulatory region DNA binding; • DNA binding; • sequence-specific DNA binding transcription factor activity; • transcription cofactor activity; • protein binding; • identical protein binding; • protein homodimerization activity;
Cellular component	• nucleus; • nucleoplasm; • cytoplasm; • cytosol;
Biological process	• toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • transcription from RNA polymerase II promoter; • induction of apoptosis; • response to DNA damage stimulus; • virus-host interaction; • cytokine-mediated signaling pathway; • negative regulation of type I interferon production; • positive regulation of type I interferon production; • positive regulation of interferon-alpha production; • positive regulation of interferon-beta production; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • MDA-5 signaling pathway; • innate immune response; • defense response to virus; • interferon-gamma-mediated signaling pathway; • type I interferon-mediated signaling pathway; • macrophage apoptotic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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