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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/05 14:08:08」(JST)

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Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.^[1]

Function

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.^[2]

Interactions

IRF2 has been shown to interact with BRD7,^[3] EP300^[4] and PCAF.^[4]^[5]

References

^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID 2475256.
^ "Entrez Gene: IRF2 interferon regulatory factor 2".
^ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.
^ ^a ^b Masumi A, Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541.
^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. PMC 83974. PMID 10022868.

External links

IRF2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

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5. 抗Ro/SSA抗体および抗La/SSB抗体の抗原抗体系 the anti ro ssa and anti la ssb antigen antibody systems

English Journal

Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster.

Huang XD1, Dai JG2, Lin KT2, Liu M2, Ruan HT2, Zhang H3, Liu WG3, He MX4, Zhao M5.
Fish & shellfish immunology.Fish Shellfish Immunol.2018 Oct;81:108-112. doi: 10.1016/j.fsi.2018.07.020. Epub 2018 Jul 12.
PMID 30017925

miR-18a-5p promotes cell invasion and migration of osteosarcoma by directly targeting IRF2.

Lu C1, Peng K1, Guo H1, Ren X1, Hu S1, Cai Y1, Han Y1, Ma L2, Xu P1.
Oncology letters.Oncol Lett.2018 Sep;16(3):3150-3156. doi: 10.3892/ol.2018.9032. Epub 2018 Jun 27.
PMID 30127908

Deletion of interferon-regulatory factor-1 results in cognitive impairment.

Mogi M1, Iwanami J2, Wang XL2, Tsukuda K2, Kan-No H2, Bai HY2, Shan BS2, Higaki A2, Min LJ2, Horiuchi M2.
Hypertension research : official journal of the Japanese Society of Hypertension.Hypertens Res.2018 Aug 6. doi: 10.1038/s41440-018-0080-y. [Epub ahead of print]
PMID 30082820

Japanese Journal

IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms.

International immunology 24(9), 573-581, 2012-07-05
NAID 120005302075

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

Proceedings of the National Academy of Sciences of the United States of America 108(46), 18766-18771, 2011-11-15
NAID 120003659756

活性化T細胞におけるNKレセプターの発現

臨床免疫・アレルギー科 55(4), 475-482, 2011-04
NAID 40018833143

★リンクテーブル★

リンク元	「interferon regulatory factor-2」「インターフェロン調節因子-2」
関連記事	「I」「IRF」「IR」

「interferon regulatory factor-2」

Interferon regulatory factor 2
	PDB rendering based on 1irf.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1irf, 1irg, 2irf
Identifiers
Symbols	IRF2 ; IRF-2
External IDs	OMIM: 147576 MGI: 96591 HomoloGene: 1659 GeneCards: IRF2 Gene
Gene ontology
Molecular function	• RNA polymerase II regulatory region sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; • DNA binding; • transcription factor activity, sequence-specific DNA binding; • protein binding;
Cellular component	• nucleoplasm; • cytoplasm; • cytosol; • focal adhesion;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • regulation of transcription, DNA-templated; • transcription from RNA polymerase II promoter; • blood coagulation; • cell proliferation; • cytokine-mediated signaling pathway; • positive regulation of transcription from RNA polymerase II promoter; • interferon-gamma-mediated signaling pathway; • type I interferon signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;