interferon regulatory factor-7

インターフェロン調節因子-7

関

IRF-7

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
12. an official responsible for control and supervision of a particular activity or area of public interest
13. an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 取り締まり人;調整者 / 調整装置
4. インターフェロン(ウイルス増殖抑制物質)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/27 05:54:17」(JST)

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Interferon regulatory factor 7
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2O61
Identifiers
Symbols	IRF7 ; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
External IDs	OMIM: 605047 MGI: 1859212 HomoloGene: 128624 GeneCards: IRF7 Gene
Gene ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • endosome membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • regulation of adaptive immune response • transcription from RNA polymerase II promoter • response to DNA damage stimulus • response to virus • immunoglobulin mediated immune response • establishment of viral latency • cytokine-mediated signaling pathway • regulation of type I interferon production • interferon-alpha production • interferon-beta production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • regulation of MyD88-dependent toll-like receptor signaling pathway • regulation of MyD88-independent toll-like receptor signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 9 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • MDA-5 signaling pathway • innate immune response • type I interferon biosynthetic process • regulation of monocyte differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of immune response • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • positive regulation of type I interferon-mediated signaling pathway • negative regulation of macrophage apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3665	54123
Ensembl	ENSG00000185507	ENSMUSG00000025498
UniProt	Q92985	P70434
RefSeq (mRNA)	NM_001572	NM_001252600
RefSeq (protein)	NP_001563	NP_001239529
Location (UCSC)	Chr 11: 0.61 – 0.62 Mb	Chr 7: 141.26 – 141.27 Mb
PubMed search	[1]	[2]

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.

See also

• Interferon regulatory factors

Interactions

IRF7 has been shown to interact with IRF3.

References

Further reading

• Ning S*, Pagano J, Barber G. (2011. Epub ahead of print: 4/14/2011

PMID 21490621). "IRF7: activation, regulation, modification, and function. (Review).". Genes & Immunity. 

• Pitha PM, Au WC, Lowther W et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487. 
• Zhang L, Pagano JS (2002). "Structure and function of IRF-7". J. Interferon Cytokine Res. 22 (1): 95–101. doi:10.1089/107999002753452700. PMID 11846980. 
• Zhang L, Pagano JS (1997). "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Mol. Cell. Biol. 17 (10): 5748–57. PMC 232423. PMID 9315633. 
• Wathelet MG, Lin CH, Parekh BS et al. (1998). "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Mol. Cell 1 (4): 507–18. doi:10.1016/S1097-2765(00)80051-9. PMID 9660935. 
• Au WC, Moore PA, LaFleur DW et al. (1998). "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". J. Biol. Chem. 273 (44): 29210–7. doi:10.1074/jbc.273.44.29210. PMID 9786932. 
• Lu R, Au WC, Yeow WS et al. (2000). "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation". J. Biol. Chem. 275 (41): 31805–12. doi:10.1074/jbc.M005288200. PMID 10924517. 
• Paris MJ, Williams BR (2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102. 
• Marié I, Smith E, Prakash A, Levy DE (2000). "Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain". Mol. Cell. Biol. 20 (23): 8803–14. doi:10.1128/MCB.20.23.8803-8814.2000. PMC 86519. PMID 11073981. 
• Smith EJ, Marié I, Prakash A et al. (2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". J. Biol. Chem. 276 (12): 8951–7. doi:10.1074/jbc.M008717200. PMID 11124948. 
• Au WC, Yeow WS, Pitha PM (2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. doi:10.1006/viro.2000.0782. PMID 11162841. 
• Lu R, Moore PA, Pitha PM (2002). "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". J. Biol. Chem. 277 (19): 16592–8. doi:10.1074/jbc.M111440200. PMID 11877397. 
• Morin P, Bragança J, Bandu MT et al. (2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". J. Mol. Biol. 316 (5): 1009–22. doi:10.1006/jmbi.2001.5401. PMID 11884139. 
• Caillaud A, Prakash A, Smith E et al. (2003). "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". J. Biol. Chem. 277 (51): 49417–21. doi:10.1074/jbc.M207484200. PMID 12374802. 
• Izmailova E, Bertley FM, Huang Q et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. 
• Yang H, Lin CH, Ma G et al. (2003). "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". J. Biol. Chem. 278 (18): 15495–504. doi:10.1074/jbc.M212940200. PMID 12604599. 
• Ning S, Hahn AM, Huye LE, Pagano JS (2003). "Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit". J. Virol. 77 (17): 9359–68. doi:10.1128/JVI.77.17.9359-9368.2003. PMC 187426. PMID 12915551. 
• Fitzgerald KA, Rowe DC, Barnes BJ et al. (2003). "LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278. 
• Lin R, Noyce RS, Collins SE et al. (2004). "The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes". J. Virol. 78 (4): 1675–84. doi:10.1128/JVI.78.4.1675-1684.2004. PMC 369457. PMID 14747533. 

External links

• IRF7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
• 2. 抗酸菌易感染性を示すメンデル型遺伝性疾患：概要 mendelian susceptibility to mycobacterial diseases an overview
• 3. 全身性硬化症（強皮症）の危険因子および考えられる原因 risk factors for and possible causes of systemic sclerosis scleroderma
• 4. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
• 5. 抗Ro/SSA抗体および抗La/SSB抗体の抗原抗体系 the anti ro ssa and anti la ssb antigen antibody systems

English Journal

• Dcp2 Decapping Protein Modulates mRNA Stability of the Critical Interferon Regulatory Factor (IRF) IRF-7.

• Li Y, Dai J, Song M, Fitzgerald-Bocarsly P, Kiledjian M.SourceAddress correspondence to Megerditch Kiledjian, kiledjian@biology.rutgers.edu.
• Molecular and cellular biology.Mol Cell Biol.2012 Mar;32(6):1164-72. Epub 2012 Jan 17.
• The mammalian Dcp2 mRNA-decapping protein functions primarily on a subset of mRNAs in a transcript-specific manner. Here we show that Dcp2 is an important modulator of genes involved in the type I interferon (IFN) response, which is the initial line of antiviral innate immune response elicited by a
• PMID 22252322

• Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN-γ-Induced Gene Expression.

• Farlik M, Rapp B, Marie I, Levy DE, Jamieson AM, Decker T.SourceAddress correspondence to Thomas Decker, Thomas.decker@univie.ac.at.
• Molecular and cellular biology.Mol Cell Biol.2012 Mar;32(6):1032-43. Epub 2012 Jan 17.
• Signal transducers and activators of transcription (STATs) and interferon regulatory factors (IRFs) share common target genes. Here we show that the Irf7 gene is regulated by transcription factors STAT1 and IRF9 in response to the type II interferon (IFN) IFN-γ. IRF7 cooperated with STAT1 and IRF1
• PMID 22252317

Japanese Journal

• Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population

• Kawasaki A,Furukawa H,Kondo Y,Ito S,Hayashi T,Kusaoi M,Matsumoto I,Tohma S,Takasaki Y,Hashimoto H,Sumida T,Tsuchiya N.
• Lupus 21(8), 890-895, 2012-07
• … Interferon regulatory factor 7 (IRF7) has an essential role in the production of type I interferon. …
• NAID 120005317387

• Early activation of interferon-stimulated genes in human liver allografts : relationship with acute rejection and histological outcome

• MINISINI Rosalba,GIARDA Paola,GROSSI Glenda,BITETTO Davide,TONIUTTO Pierluigi,FALLETI Edmondo,AVELLINI Claudio,OCCHINO Giuseppa,FABRIS Carlo,PIRISI Mario
• Journal of gastroenterology 46(11), 1307-1315, 2011-11-01
• NAID 10030294922

• 398 ヒト形質細胞様樹状細胞におけるInterferon regulatory factor-7の活性化(サイトカイン,ケモカインとその受容体2,一般演題(口演),第56回日本アレルギー学会秋季学術大会)

• 大澤 陽子,伊保 澄子,藤枝 重治
• アレルギー 55(8・9), 1222, 2006-09-30
• NAID 110004869889

Related Links

• IRF7 interferon regulatory factor 7 [Homo sapiens (human)]

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon ...

• IRF7 - Interferon regulatory factor 7 - Homo sapiens (Human)

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and ...

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★リンクテーブル★

リンク元	「IRF-7」「インターフェロン調節因子-7」
関連記事	「fact」「factor」「regulatory」「regulator」「regulatory factor」

「IRF-7」

　　[★]

• インターフェロン調節因子-7

関

interferon regulatory factor-7

「インターフェロン調節因子-7」

　　[★]

英

interferon regulatory factor-7、IRF-7

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「regulatory」

　　[★]

• adj.

• 制御の、調節性の、制御的な、(法律)規制の

関

control、modulatory、regulate、regulation

「regulator」

　　[★]

• n.

• 制御因子、レギュレーター

関

regulatory factor

　 　 　

「regulatory factor」

　　[★]

• 制御因子、調節因子

関

controlling factor、regulator