- ヒスタミンH2受容体遮断薬、ヒスタミンH2拮抗薬、ヒスタミンH2遮断薬
- 関
- H2 blocker、histamine H2 receptor antagonist
WordNet
- a drug that neutralizes or counteracts the effects of another drug
- a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
- the 8th letter of the Roman alphabet (同)h
- amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions
PrepTutorEJDIC
- 対立する人,敵対者,競争相手(opponent)
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
- ヒスタミン(子宮収縮・血圧降下の薬)
UpToDate Contents
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English Journal
- Functional and structural changes of human erythrocyte catalase induced by cimetidine: proposed model of binding.
- Yazdi F1, Minai-Tehrani D, Jahngirvand M, Almasirad A, Mousavi Z, Masoud M, Mollasalehi H.
- Molecular and cellular biochemistry.Mol Cell Biochem.2015 Jun;404(1-2):97-102. doi: 10.1007/s11010-015-2369-3. Epub 2015 Mar 5.
- In erythrocyte, catalase plays an important role to protect cells from hydrogen peroxide toxicity. Hydrogen peroxide is a byproduct compound which is produced during metabolic pathway of cells. Cimetidine, a histamine H2 receptor antagonist, is used for gastrointestinal tract diseases and prevents t
- PMID 25739358
- Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats.
- Hamzeh-Gooshchi N1, Tamaddonfard E2, Farshid AA3.
- Pharmacological reports : PR.Pharmacol Rep.2015 Jun;67(3):593-9. doi: 10.1016/j.pharep.2014.12.019. Epub 2015 Jan 15.
- BACKGROUND: The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats.METHODS:
- PMID 25933974
- The physiological background behind and course of development of the first proton pump inhibitor.
- Lundell L1.
- Scandinavian journal of gastroenterology.Scand J Gastroenterol.2015 Jun;50(6):680-4. doi: 10.3109/00365521.2015.1013981. Epub 2015 Apr 9.
- Gastric acid secretion and its related diseases and their treatments have generated important contributions to gastroenterology and its development as an autonomous medical specialty. The discovery of histamine receptors and the subsequent H2-receptor antagonists (1972) changed the practice of gastr
- PMID 25857639
Japanese Journal
- H2ブロッカーlafutidineによる薬剤誘発性せん妄--癌術後の3症例 (特集 症状性を含む器質性精神障害の症例)
- 低用量アスピリンによる消化管障害に対する酸分泌阻害薬の抑制効果に関する検討
- 中村 浩規,横山 晴子,矢口 武廣,鈴木 優司,徳岡 健太郎,渡邊 昌之,北川 泰久,山田 安彦
- YAKUGAKU ZASSHI 131(3), 445-452, 2011
- … In this study, we investigated the effect of histamin H2 receptor antagonist (H2RA) or proton pump inhibitor (PPI) for the prevention of upper gastrointestinal lesions associated with low-dose aspirin. … We classified them into three groups: aspirin alone group (n=1103), aspirin with H2RA group (n=844) and aspirin with PPI group (n=864). …
- NAID 130000678910
Related Links
- Histamine H2 Antagonist (Oral Route, Injection Route, Intravenous Route) Print Sections Description and Brand Names Before Using Proper Use Precautions Side Effects Products and services Free E-newsletter Subscribe to ...
- Detailed drug Information for histamine h2 antagonist Oral, Injection, Intravenous. Includes common brand names, drug descriptions, warnings, side effects and dosing information. ... Drugs.com provides accurate and independent ...
Related Pictures
★リンクテーブル★
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- 英
- H2 blocker H2-blockers
- 同
- H2受容体ブロッカー H2 receptor blocker、H2受容体拮抗薬 H2 receptor antagonist H2RA、ヒスタミンH2受容体遮断薬 ヒスタミンH2受容体拮抗薬 histamine H2-receptor antagonists histamine H2 receptor antagonist histamine H2 antagonist、H2拮抗薬 H2 antagonist H2-antagonist、H2遮断薬、H2ブロッカー
- 関
- 抗ヒスタミン薬
[show details]
GOO.chapter36 p.971
- 十二指腸潰瘍の治癒率を向上する (⇔プロトンポンプ阻害薬)
H2受容体拮抗薬
構造
作用機序
- H1受容体にはほとんど作用しない
- H2受容体に可逆的、競合的に結合してヒスタミンを阻害する。
- 胃粘膜の局所の肥満細胞、ECL細胞
- histamine→H2R→Csα→AC→cAMP↑→PKA→H+,K+-ATPase
- histamine→H2R→[Ca2+]i↑→H+,K+-ATPase ←補助的pathway
- H2RとMRとGRは相互作用しており、胃酸を分泌する。
注意
- 中止すると再発率が高い。そのため半年かけて漸減させゆっくり離脱
- 胃粘膜が減弱している
副作用
- 副作用5%↓
- 汎血球減少症、無顆粒球症
- 肝障害、抗アンドロゲン作用(女性化乳房、乳汁分泌)
- 中止すると再発率が高い。そのため半年かけて漸減させゆっくり離脱
- 胃粘膜が減弱しているから
相互作用
- シメチジン:CYP2D6, CYP3A4阻害作用。 CYPs(CYP1A2,CYP2C9,CYP2D6)の阻害 (GOO.972)
- ラニチジン:CYPs。しかし、シメチジンの10%程度
- ファモチジン、ニザチジン:なし
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H2拮抗薬、H2遮断薬
- 関
- H2 blocker