high mobility group protein

• 高移動度タンパク質

関

HMG

WordNet

1. in or to a high position, amount, or degree; "prices have gone up far too high"
2. a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on"
3. a state of sustained elation; "Im on a permanent high these days"
4. an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high"
5. a lofty level or position or degree; "summer temperatures reached an all-time high"
6. a high place; "they stood on high and observed the countryside"; "he doesnt like heights" (同)heights
7. at a great altitude; "he climbed high on the ladder" (同)high up
8. used of sounds and voices; high in pitch or frequency (同)high-pitched
9. happy and excited and energetic (同)in high spirits
10. slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana) (同)mellow
11. in a rich manner; "he lives high" (同)richly, luxuriously
12. (literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'
13. far up toward the source; "he lives high up the river"
14. greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself"
15. arrange into a group or groups; "Can you group these shapes together?"
16. (chemistry) two or more atoms bound together as a single unit and forming part of a molecule (同)radical, chemical group
17. any number of entities (members) considered as a unit (同)grouping
18. a set that is closed, associative, has an identity element and every element has an inverse (同)mathematical group
19. form a group or group together (同)aggroup
20. the activity of putting things together in groups
21. a system for classifying things into groups (同)pigeonholing
22. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
23. the quality of moving freely

PrepTutorEJDIC

1. 『高い』,高い所にある / 《数の後に置いて》高さが…ある / (数量・程度などが標準より)『高い』,大きい,激しい / (身分・地位が)『高い』,高貴な / 『気高い』,高潔な / (声の調子が)『高い』,鋭い / 値段の高い,金の掛かる,ぜいたくな / 楽しい,陽気な,上得意の / (時・季節が)盛りの,たけなわの / (色が)濃い,赤い / 《話》(酒・麻薬などに)酔って / 『高く』,高い所に / (価値・程度などが)高く,高度に,激しく / 〈C〉《話》高水準,高値 / 〈U〉(自動車の)高速ギア / 〈C〉《話》(麻薬などによる)酔った状態
2. (…の)『群れ』,集まり,小集団《+of+名》 / (主義・系統・種類などを同じくする人・物の)『派』,『団体』 / (ポミュラーソング歌手の)グループ / (動・植物分類上の)群;(化学の)基,原子団;(地質学上の)界;(数学の)群;(言語学上の)語派 / …‘を'一群に集める,一団にする《+『名』+『together』》 / (系統的に)…‘を'分類する,調和よく配合する《+『名』+『together』》 / 集まる,群(集団)をなす
3. グループに分けること;分類法 / (集まった物の)配置,配合
4. 蛋白(たんばく)質
5. 可動性,流動性,変わりやすさ;(軍隊の)機動力

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/07 13:11:08」(JST)

wiki en

[Wiki en表示]

High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair.

Families

The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:

• HMGA – contains an AT-hook domain
  • HMGA1
  • HMGA2

• HMGB – contains a HMG-box domain
  • HMGB1
  • HMGB2
  • HMGB3
  • HMGB4

• HMGN – contains a nucleosomal binding domain
  • HMGN1
  • HMGN2
  • HMGN3
  • HMGN4

• Sex-Determining Region Y Protein

• TCF Transcription Factors
  • Lymphoid enhancer-binding factor 1
  • T Cell Transcription Factor 1

Proteins containing any of these embedded in their sequence are known as HMG motif proteins. HMG-box proteins are found in a variety of eukaryotic organisms.

They were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels.

Function

HMG proteins are thought to play a significant role in various human disorders. Disruptions and rearrangements in the genes coding for some of the HMG proteins are associated with some common benign tumors. Antibodies to HMG proteins are found in patients suffering from autoimmune diseases. The SRY gene on the Y Chromosome, responsible for male sexual differentiation, contains an HMG-Box domain. A member of the HMG family of proteins, HMGB1, has also been shown to have an extracellular activity as a chemokine, attracting neutrophils and mononuclear inflammatory cells to the infected liver.

See also

• Gene regulatory network

• HMG-box

• Transcription factors

References

External links

• HMG nomenclature home page
• High Mobility Group Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

• Translocation of Endogenous Danger Signal HMGB1 From Nucleus to Membrane Microvesicles in Macrophages.

• Chen Y1,2, Li G2, Liu Y3, Werth VP4,5, Williams KJ1,6, Liu ML1,4,5.
• Journal of cellular physiology.J Cell Physiol.2016 Nov;231(11):2319-26. doi: 10.1002/jcp.25352. Epub 2016 Mar 9.
• High mobility group box 1 (HMGB1) is a nuclear protein that can be released from activated or dead cells. Extracellular HMGB1 can serve as a "danger signal" and novel cytokine that mediates sterile inflammation. In addition to its soluble form, extracellular HMGB1 can also be carried by membrane mic
• PMID 26909509

• Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae.

• Chen Q1, Yin YX2, Wei J3, Tong M3, Shen F4, Zhao M2, Chamley L3.
• Cytokine.Cytokine.2016 Sep;85:30-6. doi: 10.1016/j.cyto.2016.06.001. Epub 2016 Jun 7.
• BACKGROUND: Preeclampsia is a pregnancy-specific disorder characterised by an inappropriate maternal inflammatory response during pregnancy. High mobility group box 1 (HMGB1) was originally characterised as a nuclear protein but when released into the extracellular environment following necrotic cel
• PMID 27285673

• Fibroblast Growth Factor 2 Regulates High Mobility Group A2 Expression in Human Bone Marrow-Derived Mesenchymal Stem Cells.

• Kalomoiris S1, Cicchetto AC1, Lakatos K2, Nolta JA1, Fierro FA1,3.
• Journal of cellular biochemistry.J Cell Biochem.2016 Sep;117(9):2128-37. doi: 10.1002/jcb.25519. Epub 2016 Mar 8.
• Mesenchymal stem cells (MSCs) are an excellent source for numerous cellular therapies due to their simple isolation, low immunogenicity, multipotent differentiation potential and regenerative secretion profile. However, over-expanded MSCs show decreased therapeutic efficacy. This shortcoming may be
• PMID 26888666

Japanese Journal

• HMGB1制御のためのアフェレシス(<特集>敗血症とアフェレシス)

• 西田 修,湯本 美穂,森山 和広,加藤 由布,下村 泰代,中村 智之,栗山 英直,原 嘉孝,伊藤 舞,野田 昌宏,秋山 正慶,早川 聖子,小松 聖史,山田 晋吾,宮庄 拓
• 日本アフェレシス学会雑誌 31(2), 148-155, 2012-05-31
• … The high mobility group box 1 protein (HMGB1) is an alarmin that plays an important role in sepsis and has been recognized as a promising target with a wide therapeutic window ; … High cut-off (HCO) membrane showed lower clearance than the adsorbing-membranes such as PMMA and AN69ST. AN69ST showed the dramatically high adsorption clearance of 60 mL/min in dealing with 100 mL/min of test solution flow. …
• NAID 110009444663

• The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation

• FUMIMOTO Reiko,SAKAI Eiko,YAMAGUCHI Yu,SAKAMOTO Hiroshi,FUKUMA Yutaka,NISHISHITA Kazuhisa,OKAMOTO Kuniaki,TSUKUBA Takayuki
• Journal of pharmacological sciences 118(4), 479-486, 2012-04-20
• … Moreover, the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), a master regulator for OCL differentiation; … As one of the molecular mechanisms for the inhibitory effects of kahweol, we also showed that kahweol up-regulated heme oxygenase-1 and inhibited high mobility group box 1 release. …
• NAID 10030572053

• アルツハイマー病・パーキンソン病・レヴィー小体型認知症例の 血中High mobility group box 1 蛋白の検討

• 伊藤 昭三,河西 美代子,横尾 智子 [他]
• 新渡戸文化短期大学学術雑誌 = Journal of Nitobe Bunka College 2, 37-39, 2012
• NAID 40019479678

Related Links

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• high-mobility group protein - Definition

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Related Pictures

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★リンクテーブル★

リンク元	「HMG」「HMG蛋白質」「高移動度タンパク質」
関連記事	「group」「grouping」「high」「mobility」「grouped」

「HMG」

　　[★]

• 高移動度タンパク質 high mobility group protein
• 3-hydroxy 3-methylglutaryl

「HMG蛋白質」

　　[★]

英

HMG protein

同

高速移動群蛋白質 high mobility group protein

「高移動度タンパク質」

　　[★]

英

high mobility group protein、HMG

「group」

　　[★]

• n.

• 集団、グループ、(動物)群れ、(分類学)群、(化学)基

• v.

• 分類する、グループ化する

関

assortment、categorization、categorize、category、class、classification、classifier、classify、cluster、collective、grouping、herd、mass、population、sort、swarm、systematization、typing

　 　 　 　 　 　

「grouping」

　　[★]

• n.

• 分類、グルーピング、グループ化、群化

関

assortment、categorization、categorize、category、class、classification、classifier、classify、group、grouped、sort、systematization、typing

　 　 　

「high」

　　[★]

• adj.

• 高い、高度な

関

advanced、altitude、high degree、high level、high-grade、highly、tall

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「mobility」

　　[★]

• n.

• 移動度、移動性、易動度、可動性、機動力

関

flexibility、flexible、locomotive、migrating、mobile、movable

　 　

「grouped」

　　[★]

• adj.

• 群化の

関

grouping