HMG蛋白質
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 8th letter of the Roman alphabet (同)h
PrepTutorEJDIC
- 蛋白(たんばく)質
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/03 00:25:07」(JST)
[Wiki en表示]
High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair.[1]
Contents
- 1 Families
- 2 Function
- 3 See also
- 4 References
- 5 External links
Families
The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:
- HMGA – contains an AT-hook domain
- HMGB – contains a HMG-box domain
- HMGN – contains a nucleosomal binding domain
- Sex-Determining Region Y Protein
- TCF Transcription Factors
- Lymphoid enhancer-binding factor 1
- T Cell Transcription Factor 1
Proteins containing any of these embedded in their sequence are known as HMG motif proteins. HMG-box proteins are found in a variety of eukaryotic organisms.
They were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels.[2]
Function
HMG proteins are thought to play a significant role in various human disorders. Disruptions and rearrangements in the genes coding for some of the HMG proteins are associated with some common benign tumors. Antibodies to HMG proteins are found in patients suffering from autoimmune diseases. The SRY gene on the Y Chromosome, responsible for male sexual differentiation, contains an HMG-Box domain. A member of the HMG family of proteins, HMGB1, has also been shown to have an extracellular activity as a chemokine, attracting neutrophils and mononuclear inflammatory cells to the infected liver.[3]
See also
References
- ^ Rajeswari MR, Jain A (2002). "High-mobility-group chromosomal proteins, HMGA1 as potential tumour markers" (PDF). Current Science 82 (7): 838–844.
- ^ Johns EB (1982). The HMG chromosomal proteins. Boston: Academic Press. ISBN 0-12-386050-4.
- ^ Sitia G, Iannacone M, Müller S, Bianchi ME, Guidotti LG (January 2007). "Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice". J. Leukoc. Biol. 81 (1): 100–7. doi:10.1189/jlb.0306173. PMID 16935945.
External links
- HMG nomenclature home page
- High Mobility Group Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Microbe- and danger-induced inflammation.
- Broggi A1, Granucci F2.
- Molecular immunology.Mol Immunol.2015 Feb;63(2):127-33. doi: 10.1016/j.molimm.2014.06.037. Epub 2014 Jul 16.
- The ability of the immune system to give rise to an effective response against pathogens while maintaining tolerance towards self-tissues has always been an object of keen interest for immunologist. Over the years, different theories have been proposed to explain if and how the immune system is able
- PMID 25037632
- Epidemiological-molecular evidence of metabolic reprogramming on proliferation, autophagy and cell signaling in pancreas cancer.
- Søreide K1, Sund M2.
- Cancer letters.Cancer Lett.2015 Jan 28;356(2):281-8. doi: 10.1016/j.canlet.2014.03.028. Epub 2014 Apr 2.
- Pancreatic cancer remains one of the deadliest human cancers with little progress made in survival over the past decades, and 5-year survival usually below 5%. Despite this dismal scenario, progresses have been made in understanding of the underlying tumor biology through among other definition of p
- PMID 24704294
- Receptor for advanced glycation endproducts and progressive kidney disease.
- Fukami K1, Taguchi K, Yamagishi SI, Okuda S.
- Current opinion in nephrology and hypertension.Curr Opin Nephrol Hypertens.2015 Jan;24(1):54-60.
- PURPOSE OF REVIEW: Receptor for advanced glycation endproducts (RAGE) is a multiligand receptor of the immunoglobulin superfamily, which binds not only to advanced glycation endproducts, but also to high-mobility group box-1, S100/calgranulins, amyloid fibrils, and lipopolysaccharide. We discuss the
- PMID 25470016
Japanese Journal
- 脂質異常症治療薬の副作用・薬物相互作用におけるモノカルボン酸トランスポータの役割
- 3P125 DNAを湾曲するHMG-1/2は塩基配列非特異的に長鎖DNAを折り畳み(05B. 核酸:相互作用・複合体,ポスター,第52回日本生物物理学会年会(2014年度))
- Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy
Related Links
- Aravind L, Landsman D AT-hook motifs identified in a wide variety of DNA-binding proteins. Nucleic Acids Res. 1998; 26: 4413-21 Display abstract The AT-hook is a small DNA-binding protein motif which was first described in the high ...
- As a tool for theoretical prediction of the structure, we have chosen molecular dynamics (MD) simulations which our group has used already as a powerful method for bridging experimental and theoretical studies of protein-DNA ...
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- HMG protein
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- 高速移動群蛋白質 high mobility group protein
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