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1. バレット食道：ラジオ波焼灼術による治療barretts esophagus treatment with radiofrequency ablation [show details]
…treatment of the Z-line (at least once) Small tongues of BE; Scattered islands of BE; Focal RFA with the Barrx90 catheter also uses radiofrequency energy to ablate small areas of BE. For focal ablation, the …
2. 膝の身体診察physical examination of the knee [show details]
… knee should include the anterior joint line (including lateral and medial aspects), anterior knee off the joint line, posterior knee, bursae, and skin temperature. Focal tenderness at a specific site usually …
3. 原発性局所多汗症primary focal hyperhidrosis [show details]
…hyperhidrosis; Focal sweating stops during sleep; Patients with primary focal hyperhidrosis generally develop symptoms in childhood or adolescence that persist throughout life. Patients have focal symptoms… Society for patients who cannot be managed with first-line and second-line therapies.…
4. 胸膜のプラーク、肥厚、および腫瘍の画像imaging of pleural plaques thickening and tumors [show details]
…This impingement may occasionally cause a pulmonary subpleural curvilinear line adjacent to the plaque, which is indicative of focal lung fibrosis. CT clearly distinguishes pleural plaques from extrapleural …
5. 成人における痙攣性のてんかん重積状態：治療および予後convulsive status epilepticus in adults treatment and prognosis [show details]
… commonly used as a first-line therapy for status epilepticus . Although comparative data are relatively limited, one observational study found that first-line therapy with clonazepam… The EEG pattern was focal or focal with secondary generalization in most patients.…

English Journal

Starting Line for Scholarly Activity in New Residency Programs: Lessons Learned for Institutional Success.

Sciarretta JD, Atchison CD, Onayemi AO, Davis JM.
The Journal of surgical research. 2019 Jul;239()136-141.
One focal point of Graduate Medical Education (GME) is scholarly activity and its integration into clinical practice by evidence-based learning. Program directors and educational leaders view scholarly work as the foundation for continuing resident education; however, the high demand of scholarly ac
PMID 30826564

Conservative treatment of diffuse infiltrating retinoblastoma: optical coherence tomography-assisted diagnosis and follow-up in three consecutive cases.

Stathopoulos C, Moulin A, Gaillard MC, Beck-Popovic M, Puccinelli F, Munier FL.
The British journal of ophthalmology. 2019 Jun;103(6)826-830.
To report conservative therapy in diffuse infiltrating retinoblastoma (DIR) and describe specific optic coherence tomography (OCT) features of the tumour. Retrospective review of all DIR cases treated conservatively between 1998 and 2012. Three patients (three eyes) were included, cases 1 and 3 wit
PMID 30049803

An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy.

Reimers A, Ljung H.
Expert opinion on pharmacotherapy. 2019 Jun;20(8)909-915.
About 70 million people worldwide are estimated to suffer from epilepsy. Despite a large variety of old and new antiepileptic drugs on the market, about 30% of people with epilepsy do not become seizure-free with medical treatment. This is a major individual and public health burden. Most of these d
PMID 30908087

Japanese Journal

LIBSによる合金スクラップの選別

葛谷幹夫
中部大学工学部紀要 (54), 47-50, 2019-03
… In order to reduce the effect of the changes in the sample height, an objective lens having a long focal length of 600 mm was used to generate plasmas, and the method of internal standard, which normalizes the line intensity of the analyte element to the line intensity of the matrix element, was used. …
NAID 120006628755

『ディア・ノーバディ』における10代の妊娠

井上美雪
東洋大学社会学部紀要 = The Bulletin of Faculty of Sociology,Toyo University 56(1), 29-40, 2018-12
… When Young Adult novels deal with sensitive themes such as teenage sexuality and teenage pregnancy, the books need to be in line with educational appropriateness for adolescent readers. … Helen could be the focal point of such arguments, but the story rather focuses on mother-daughter relationship, implying that the sexuality of adolescents should first be treated as something private. …
NAID 120006604935

5-Chloro-2,4-dihydroxypyridine, CDHP, prevents lung metastasis of basal-like breast cancer cells by reducing nascent adhesion formation

Itou Junji,Tsukihara Hiroshi,Nukatsuka Mamoru,Toi Masakazu,Takechi Teiji
Cancer Medicine 7(2), 463-470, 2018-02
… At the molecular level, CDHP treatment reduced the number of nascent adhesions, whereas the number of mature focal adhesions was not changed. … These findings indicate that CDHP impairs focal adhesion formation, which results in a reduction in cell migration. … For the in vivo metastasis assay, we used a highly lung‐metastatic cell line. …
NAID 120006457115

「FL」

　　[★]

「LINE」

　　[★]

日: 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
英: long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
関: レトロトランスポゾン

quoted from http://en.wikipedia.org/wiki/Long_interspersed_nucleotide_elements#LINEs

Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.

The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.