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1. What's new in pediatricswhats new in pediatrics [show details]
…proxy outcome measure for repetitive behaviors and a relatively mild level of symptoms among participants. We reserve fluoxetine therapy for children with ASD and repetitive behaviors that interfere with …
2. 精巣癌の長期生存者のケアへのアプローチapproach to the care of long term testicular cancer survivors [show details]
…possible long-term consequences of treatment for testicular cancer and the young age at which many men undergo treatment, long-term follow-up is suggested. We suggest the following guidelines for long-term… Key elements used to determine the treatment plan include the following : Histology (ie,…
3. スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：管理、予後、および長期の後遺症stevens johnson syndrome and toxic epidermal necrolysis management prognosis and long term sequelae [show details]
…"SJS/TEN" to refer collectively to SJS, TEN, and SJS/TEN overlap. The management, prognosis, and long-term sequelae of SJS/TEN are discussed in this topic. The pathogenesis, clinical manifestations, and … management involves the following elements: Sterile handling is essential .…
4. レット症候群：遺伝学、臨床的特徴、診断rett syndrome genetics clinical features and diagnosis [show details]
… modulation of transcription and retrotransposition of long interspersed nuclear elements-1 (L1s) in neurons,… The contribution of increased energy expenditure due to involuntary repetitive movements is uncertain.…
5. コンタクトレンズの合併症complications of contact lenses [show details]
… collagen fibrils with cellular infiltration and interspersed refractile elements .… is retained in the eye for hours or weeks with repetitive pressing and sliding on the cornea with each blink.… Chronic hypoxia and acidosis in long-term contact lens wearers may cause permanent morphologic changes,…

English Journal

Rapid detection of porcine DNA in processed food samples using a streamlined DNA extraction method combined with the SYBR Green real-time PCR assay.

Tan LL, Ahmed SA, Ng SK, Citartan M, Raabe CA, Rozhdestvensky TS, Tang TH.
Food chemistry. 2020 Mar;309()125654.
A specialized DNA extraction method and a SYBR Green quantitative polymerase chain reaction (SyG-qPCR) assay were combined to generate a ready-to-use kit for rapid detection of porcine admixtures in processed meat products. Our qPCR assay utilized repetitive LINE-1 elements specific to the genome of
PMID 31678669

On transposons and totipotency.

, T T, M M, M M, .
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2020 Mar;375(1795)20190339.
Our perception of the role of the previously considered 'selfish' or 'junk' DNA has been dramatically altered in the past 20 years or so. A large proportion of this non-coding part of mammalian genomes is repetitive in nature, classified as either satellites or transposons. While repetitive elements
PMID 32075562

Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells.

McKerrow W, Tang Z, Steranka JP, Payer LM, Boeke JD, Keefe D, Fenyö D, Burns KH, Liu C.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2020 Mar;375(1795)20190335.
Long interspersed element-1 (LINE-1, L1) sequences, which comprise about 17% of human genome, are the product of one of the most active types of mobile DNAs in modern humans. LINE-1 insertion alleles can cause inherited and de novo genetic diseases, and LINE-1-encoded proteins are highly expressed i
PMID 32075555

Japanese Journal

PCR Detection of DNAs of Animal Origin in Feed by Primers Based on Sequences of Short and Long Interspersed Repetitive Elements

Tajima Kiyoshi,Enishi Osamu,Amari Masahiro [他],MITSUMORI Makoto,KAJIKAWA Hiroshi,KURIHARA Mitsunori,YANAI Satoshi,MATSUI Hiroki,YASUE Hiroshi,MITSUHASHI Tadayoshi,KAWASHIMA Tomoyuki,MATSUMOTO Mitsuo
Bioscience, biotechnology, and biochemistry 66(10), 2247-2250, 2002-10-23
… PCR primers for the detection of materials derived from ruminants, pigs, and chickens were newly designed on the basis of sequences of the Art2 short interspersed repetitive element (SINE), PRE-1 SINE, and CR1 long interspersed repetitive element (LINE), respectively. …
NAID 110002693546

Genomic Structure of the Rat and Mouse Histamine N-Methyltransferase Gene

Kitanaka Nobue,Kitanaka Junichi,Oue Tetsuya [他],TADA Yoshihiko,TANAKA Tatsuya,TAKEMURA Motohiko
The Japanese journal of pharmacology 88(1), 85-92, 2002-01-01
… Several long interspersed repetitive elements were located in the 5' flanking region of the rat and mouse HMT gene. …
NAID 10007944851

The 3' ends of tRNA-derived short interspersed repetitive elements are derived from the 3' ends of long interspersed repetitive elements.

OHSHIMA K.
Mol. Cell. Biol. 16, 3756-3764, 1996
NAID 80009024239

「LINE」

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日: 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
英: long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
関: レトロトランスポゾン

quoted from http://en.wikipedia.org/wiki/Long_interspersed_nucleotide_elements#LINEs

Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.

The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.