fibroblast growth factor 2

bFGF

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. be a contributing factor; "make things factor into a companys profitability"
13. any of the numbers (or symbols) that form a product when multiplied together
14. an independent variable in statistics
15. anything that contributes causally to a result; "a number of factors determined the outcome"
16. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
17. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
18. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
19. a concept whose truth can be proved; "scientific hypotheses are not facts"
20. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
21. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
22. a cell from which connective tissue develops

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
4. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/07 07:55:19」(JST)

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[Wiki en表示]

FGF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Identifiers
Aliases	FGF2, BFGF, FGF-2, FGFB, HBGF-2, fibroblast growth factor 2
External IDs	MGI: 95516 HomoloGene: 1521 GeneCards: 2247
Gene ontology Molecular function • cytokine activity • heparin binding • fibroblast growth factor receptor binding • protein binding • ligand-dependent nuclear receptor transcription coactivator activity • chemoattractant activity • growth factor activity • receptor binding • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • extracellular region • nucleus • extracellular fluid Biological process • release of sequestered calcium ion into cytosol • cell differentiation • negative regulation of fibroblast migration • hyaluronan catabolic process • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • negative regulation of blood vessel endothelial cell migration • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • somatic stem cell population maintenance • positive regulation of phospholipase C activity • extracellular matrix organization • wound healing • negative regulation of cell death • regulation of angiogenesis • nervous system development • cell migration involved in sprouting angiogenesis • MAPK cascade • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of transcription, DNA-templated • chemotaxis • fibroblast growth factor receptor signaling pathway • chondroblast differentiation • multicellular organism development • growth factor dependent regulation of skeletal muscle satellite cell proliferation • branching involved in ureteric bud morphogenesis • positive regulation of cardiac muscle cell proliferation • activation of MAPK activity • embryonic morphogenesis • angiogenesis • positive regulation of blood vessel endothelial cell migration • positive regulation of cell fate specification • positive regulation of ERK1 and ERK2 cascade • organ morphogenesis • regulation of endothelial cell chemotaxis to fibroblast growth factor • phosphatidylinositol biosynthetic process • inositol phosphate biosynthetic process • negative regulation of wound healing • Ras protein signal transduction • positive regulation of cell division • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • positive chemotaxis • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2247	14173
Ensembl	ENSG00000138685	ENSMUSG00000037225
UniProt	P09038	P15655
RefSeq (mRNA)	NM_002006	NM_008006
RefSeq (protein)	NP_001997.5	NP_032032.1
Location (UCSC)	Chr 4: 122.83 – 122.9 Mb	Chr 3: 37.35 – 37.41 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Basic fibroblast growth factor, also known as bFGF, FGF2 or FGF-β, is a member of the fibroblast growth factor family.

Function

In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.

It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate-degrading enzymes activates bFGF, thus mediating the formation of new blood vessels, a process known as angiogenesis.

In addition, it is synthesized and secreted by human adipocytes and the concentration of bFGF correlates with the BMI in blood samples. In this study, bFGF was also shown to act on preosteoblasts – in the form of an increased proliferation – after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase.

bFGF has been shown in preliminary animal studies to protect the heart from injury associated with a heart attack, reducing tissue death and promoting improved function after reperfusion.

Recent evidence has shown that low levels of FGF2 play a key role in the incidence of excessive anxiety.

Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems. FGF2, in conjunction with BMP4, promote differentiation of stem cells to mesodermal lineages. After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells.

Interactions

Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1, RPL6 and ribosomal protein S19.

See also

• Angiogenesis
• Anxiety disorders
• Cytokine
• Fibroblast growth factor
• Growth factor
• Proteases in angiogenesis
• Receptor (biochemistry)
• Signal transduction

References

Further reading

• Ornitz DM, Itoh N (2001). "Fibroblast growth factors". Genome Biology. 2 (3): REVIEWS3005. doi:10.1186/gb-2001-2-3-reviews3005. PMC 138918. PMID 11276432. 
• Orpana A, Salven P (Feb 2002). "Angiogenic and lymphangiogenic molecules in hematological malignancies". Leukemia & Lymphoma. 43 (2): 219–24. doi:10.1080/10428190290005964. PMID 11999550. 
• Marie PJ, Debiais F, Haÿ E (2003). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histology and Histopathology. 17 (3): 877–85. PMID 12168799. 
• Zhao XC, Zhang LM, Tong DY, An P, Jiang C, Zhao P, Chen WM, Wang J (Mar 2013). "Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats". Neurochemical Research. 38 (3): 530–7. doi:10.1007/s11064-012-0945-4. PMC 3574197. PMID 23247820. 
• Vincent T, Saklatvala J (Jun 2006). "Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?". Biochemical Society Transactions. 34 (Pt 3): 456–7. doi:10.1042/BST0340456. PMID 16709186. 
• Ribatti D, Vacca A, Rusnati M, Presta M (2007). "The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies". Cytokine & Growth Factor Reviews. 18 (3-4): 327–34. doi:10.1016/j.cytogfr.2007.04.011. PMID 17537668. 
• Watson R, Anthony F, Pickett M, Lambden P, Masson GM, Thomas EJ (Sep 1992). "Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients". Biochemical and Biophysical Research Communications. 187 (3): 1227–31. doi:10.1016/0006-291X(92)90434-M. PMID 1417798. 
• Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC (Jan 1991). "Three-dimensional structures of acidic and basic fibroblast growth factors". Science. 251 (4989): 90–3. doi:10.1126/science.1702556. PMID 1702556. 
• Eriksson AE, Cousens LS, Weaver LH, Matthews BW (Apr 1991). "Three-dimensional structure of human basic fibroblast growth factor". Proceedings of the National Academy of Sciences of the United States of America. 88 (8): 3441–5. doi:10.1073/pnas.88.8.3441. PMC 51463. PMID 1707542. 
• Ago H, Kitagawa Y, Fujishima A, Matsuura Y, Katsube Y (Sep 1991). "Crystal structure of basic fibroblast growth factor at 1.6 A resolution". Journal of Biochemistry. 110 (3): 360–3. PMID 1769963. 
• Florkiewicz RZ, Shibata F, Barankiewicz T, Baird A, Gonzalez AM, Florkiewicz E, Shah N (1992). "Basic fibroblast growth factor gene expression". Annals of the New York Academy of Sciences. 638: 109–26. doi:10.1111/j.1749-6632.1991.tb49022.x. PMID 1785797. 
• Zhang JD, Cousens LS, Barr PJ, Sprang SR (Apr 1991). "Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta". Proceedings of the National Academy of Sciences of the United States of America. 88 (8): 3446–50. doi:10.1073/pnas.88.8.3446. PMC 51464. PMID 1849658. 
• Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Sep 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". The Journal of Biological Chemistry. 266 (25): 16778–85. PMID 1885605. 
• Fukushima Y, Byers MG, Fiddes JC, Shows TB (1991). "The human basic fibroblast growth factor gene (FGFB) is assigned to chromosome 4q25". Cytogenetics and Cell Genetics. 54 (3-4): 159–60. doi:10.1159/000132983. PMID 2265560. 
• Lafage-Pochitaloff M, Galland F, Simonetti J, Prats H, Mattei MG, Birnbaum D (1990). "The human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27". Oncogene Research. 5 (3): 241–4. PMID 2320377. 
• Story MT, Esch F, Shimasaki S, Sasse J, Jacobs SC, Lawson RK (Feb 1987). "Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue". Biochemical and Biophysical Research Communications. 142 (3): 702–9. doi:10.1016/0006-291X(87)91471-9. PMID 2435284. 
• Kurokawa T, Sasada R, Iwane M, Igarashi K (Mar 1987). "Cloning and expression of cDNA encoding human basic fibroblast growth factor". FEBS Letters. 213 (1): 189–94. doi:10.1016/0014-5793(87)81489-8. PMID 2435575. 
• Prats H, Kaghad M, Prats AC, Klagsbrun M, Lélias JM, Liauzun P, Chalon P, Tauber JP, Amalric F, Smith JA (Mar 1989). "High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons". Proceedings of the National Academy of Sciences of the United States of America. 86 (6): 1836–40. doi:10.1073/pnas.86.6.1836. PMC 286799. PMID 2538817. 
• Florkiewicz RZ, Sommer A (Jun 1989). "Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons". Proceedings of the National Academy of Sciences of the United States of America. 86 (11): 3978–81. doi:10.1073/pnas.86.11.3978. PMC 287371. PMID 2726761. 
• Abraham JA, Whang JL, Tumolo A, Mergia A, Fiddes JC (1987). "Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells". Cold Spring Harbor Symposia on Quantitative Biology. 51 Pt 1: 657–68. doi:10.1101/sqb.1986.051.01.078. PMID 3472745. 
• Sommer A, Brewer MT, Thompson RC, Moscatelli D, Presta M, Rifkin DB (Apr 1987). "A form of human basic fibroblast growth factor with an extended amino terminus". Biochemical and Biophysical Research Communications. 144 (2): 543–50. doi:10.1016/S0006-291X(87)80001-3. PMID 3579930. 

External links

• Basic Fibroblast Growth Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

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• Zheng X, Gai X, Han S, Moser CD, Hu C, Shire AM, Floyd RA, Roberts LR.SourceDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China; Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN.
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Japanese Journal

• bFGF徐放性人工真皮の基礎的評価と臨床応用について (特集 人工真皮の現況と展望)

• 形成外科 58(12), 1303-1313, 2015-12
• NAID 40020670687

• Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

• Annals of neurology 78(5), 814-823, 2015-11
• NAID 120005678336

• The effect of basic fibroblast growth factor on regeneration in a surgical wound model of rat submandibular glands

• International Journal of Oral Science, 2015-11
• NAID 120005676942

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★リンクテーブル★

リンク元	「線維芽細胞増殖因子」
拡張検索	「fibroblast growth factor-2」
関連記事	「grow」「fact」「factor」「fibroblast」「growth」

「線維芽細胞増殖因子」

　　[★]

英

fibroblast growth factor, FGF

同

線維芽細胞成長因子, ヘパリン結合性増殖因子 heparin-binding growth factor HBGF

関

bFGF、FGFファミリー

種類

• fibroblast growth factor 1 FGF-1 acidic FGF
• fibroblast growth factor 2 FGF-2 basic FGF
• fibroblast growth factor 3 FGF-3
• fibroblast growth factor 7 FGF-7 Keratinocyte growth factor

「fibroblast growth factor-2」

　　[★]

線維芽細胞増殖因子2、線維芽細胞増殖因子-2、線維芽細胞成長因子2、線維芽細胞成長因子-2

関

basic fibroblast growth factor、FGF-2、FGF2

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「fibroblast」

　　[★] 線維芽細胞

同

fibroblasts, scleroderma phenotype

　

「growth」

　　[★]

• n.

• 成長