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the 6th letter of the Roman alphabet (同)f

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/14 03:52:48」(JST)

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Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene.^[1]^[2]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.^[3]

In mice with diet-induced diabetes, the equivalent of type 2 diabetes in humans, a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for > 2 days.^[4]

Interactions

FGF1 has been shown to interact with:

CSNK2A2,^[5]
CSNK2B,^[5]
CSNK2A1,^[5]
FIBP,^[6]
FGFR1,^[7]^[8]
FGFR2^[8]^[9]^[10]
FGFR3,^[8]^[11]
FGFR4,^[12]^[13]
HSPA9,^[14] and
S100A13.^[15]^[16]

References

^ Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (Sep 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal 9 (9): 2685–92. PMC 551973. PMID 1697263.
^ Jaye M, Howk R, Burgess W, Ricca GA, Chiu IM, Ravera MW, O'Brien SJ, Modi WS, Maciag T, Drohan WN (Aug 1986). "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization". Science 233 (4763): 541–5. doi:10.1126/science.3523756. PMID 3523756.
^ "Entrez Gene: FGF1 fibroblast growth factor 1 (acidic)".
^ Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM (Sep 2014). "Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer". Nature 513 (7518): 436–9. doi:10.1038/nature13540. PMID 25043058. Lay summary – Salk Institute.
^ ^a ^b ^c Skjerpen CS, Nilsen T, Wesche J, Olsnes S (Aug 2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". The EMBO Journal 21 (15): 4058–69. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
^ Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S (Nov 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". The Biochemical Journal 336 (1): 213–22. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.
^ Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M (Sep 2000). "Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization". Molecular Cell 6 (3): 743–50. doi:10.1016/s1097-2765(00)00073-3. PMID 11030354.
^ ^a ^b ^c Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM (Jan 1996). "Expression and biological activity of mouse fibroblast growth factor-9". The Journal of Biological Chemistry 271 (3): 1726–31. doi:10.1074/jbc.271.3.1726. PMID 8576175.
^ Stauber DJ, DiGabriele AD, Hendrickson WA (Jan 2000). "Structural interactions of fibroblast growth factor receptor with its ligands". Proceedings of the National Academy of Sciences of the United States of America 97 (1): 49–54. doi:10.1073/pnas.97.1.49. PMC 26614. PMID 10618369.
^ Pellegrini L, Burke DF, von Delft F, Mulloy B, Blundell TL (Oct 2000). "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin". Nature 407 (6807): 1029–34. doi:10.1038/35039551. PMID 11069186.
^ Chellaiah A, Yuan W, Chellaiah M, Ornitz DM (Dec 1999). "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity". The Journal of Biological Chemistry 274 (49): 34785–94. doi:10.1074/jbc.274.49.34785. PMID 10574949.
^ Loo BB, Darwish KK, Vainikka SS, Saarikettu JJ, Vihko PP, Hermonen JJ, Goldman AA, Alitalo KK, Jalkanen MM (May 2000). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". The International Journal of Biochemistry & Cell Biology 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. PMID 10736564.
^ Kan M, Wu X, Wang F, McKeehan WL (May 1999). "Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase". The Journal of Biological Chemistry 274 (22): 15947–52. doi:10.1074/jbc.274.22.15947. PMID 10336501.
^ Mizukoshi E, Suzuki M, Loupatov A, Uruno T, Hayashi H, Misono T, Kaul SC, Wadhwa R, Imamura T (Oct 1999). "Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin". The Biochemical Journal 343 (2): 461–6. doi:10.1042/0264-6021:3430461. PMC 1220575. PMID 10510314.
^ Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T (Aug 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry 273 (35): 22224–31. doi:10.1074/jbc.273.35.22224. PMID 9712836.
^ Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T (Jul 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry 276 (27): 25549–57. doi:10.1074/jbc.M102925200. PMID 11432880.

UpToDate Contents

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English Journal

Complement Component 3 Is Associated with Metabolic Comorbidities in Older HIV-Positive Adults.

Bryant AK1, Fazeli PL2, Letendre SL1, Ellis RJ1,3, Potter M1, Burdo TH4, Singh KK5, Jeste DV2,6, Grant I1,2, Moore DJ1,2.
AIDS research and human retroviruses.AIDS Res Hum Retroviruses.2015 Dec 15. [Epub ahead of print]
Our objective was to evaluate the association of plasma inflammatory biomarkers with MetS in an older population of treated HIV-infected (HIV+) as compared to age-matched HIV-negative (HIV-) adults. This was done in a retrospective observational study. Plasma concentrations of complement component 3
PMID 26499082

Activation of FGF1B Promoter and FGF1 Are Involved in Cardiogenesis Through the Signaling of PKC, but Not MAPK.

Lin HY1,2,3, Lee DC1, Wang HD2,3, Chi YH1,2, Chiu IM1,2,4.
Stem cells and development.Stem Cells Dev.2015 Dec 15;24(24):2853-2863. Epub 2015 Oct 8.
Heart disease is the leading cause of human death in the 21st century. Heart transplantation is a promising way to treat this. Because donor resources are limited, cell-based therapy has been developed as an alternative. Therefore, genes that trigger cardiogenesis could have potential in the treatme
PMID 26414172

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken.

Johnsson M1, Jonsson KB2, Andersson L2, Jensen P1, Wright D3.
G3 (Bethesda, Md.).G3 (Bethesda).2015 Dec 4. pii: g3.115.024299. doi: 10.1534/g3.115.024299. [Epub ahead of print]
Life history traits such as fecundity are important to evolution, because they make up components of lifetime fitness. Due to their polygenic architectures, they are difficult to investigate with genetic mapping. Therefore, little is known about their molecular basis. One possible way towards findin
PMID 26637433

Japanese Journal

FGF-1-Induced Reactions for Biogenesis of apoE-HDL are Mediated by Src in Rat Astrocytes

NISHIDA Tomo,ITO Jin-ichi,NAGAYASU Yuko,YOKOYAMA Shinji
The journal of biochemistry 146(6), 881-886, 2009-12-01
NAID 10026305404

Increase in apoE/HDL generation of astrocytes by FGF-1 to protect the brain from stress and injury

伊藤仁一,YOKOYAMA Shinji
脂質生化学研究 51, 3, 2009-07-10
NAID 10025569995

Related Pictures

★リンクテーブル★

リンク元	「線維芽細胞増殖因子」「線維芽細胞増殖因子-1」「fibroblast growth factor-1」「acidic fibroblast growth factor」
関連記事	「FGF」「F」「FGFs」

「線維芽細胞増殖因子」

Fibroblast growth factor 1 (acidic)
	PDB rendering based on 1afc.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1QCT, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2LDN, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4QO3
Identifiers
Symbols	FGF1 ; AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1
External IDs	OMIM: 131220 MGI: 95515 HomoloGene: 625 ChEMBL: 2120 GeneCards: FGF1 Gene
Gene ontology
Molecular function	• fibroblast growth factor receptor binding; • protein binding; • growth factor activity; • heparin binding; • S100 protein binding;
Cellular component	• extracellular region; • proteinaceous extracellular matrix; • extracellular space; • nucleoplasm; • cytosol; • cell cortex;
Biological process	• angiogenesis; • organ induction; • signal transduction; • epidermal growth factor receptor signaling pathway; • multicellular organismal development; • positive regulation of cell proliferation; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • anatomical structure morphogenesis; • lung development; • positive regulation of cell migration; • cellular response to heat; • Fc-epsilon receptor signaling pathway; • positive regulation of MAP kinase activity; • innate immune response; • positive regulation of cholesterol biosynthetic process; • positive regulation of angiogenesis; • positive regulation of transcription from RNA polymerase II promoter; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • positive regulation of epithelial cell proliferation; • positive regulation of cell division; • branch elongation involved in ureteric bud branching; • positive regulation of ERK1 and ERK2 cascade; • mesonephric epithelium development; • positive regulation of intracellular signal transduction; • regulation of endothelial cell chemotaxis to fibroblast growth factor;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;