early growth response transcription factor

初期増殖応答転写因子

関

EGR transcription factor

WordNet

1. very young; "at an early age"
2. before the usual time or the time expected; "she graduated early"; "the house was completed ahead of time" (同)ahead of time, too soon
3. in good time; "he awoke betimes that morning" (同)betimes
4. belonging to the distant past; "the early inhabitants of Europe"; "former generations"; "in other times" (同)former, other
5. at or near the beginning of a period of time or course of events or before the usual or expected time; "early morning"; "an early warning"; "early diagnosis"; "an early death"; "took early retirement"; "an early spring"; "early varieties of peas and tomatoes mature before most standard varieties"
6. being or occurring at an early stage of development; "in an early stage"; "early forms of life"; "early man"; "an early computer"
7. expected in the near future; "look for an early end to the negotiations"
8. of an early stage in the development of a language or literature; "the Early Hebrew alphabetical script is that used mainly from the 11th to the 6th centuries B.C."; "Early Modern English is represented in documents printed from 1476 to 1700"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. be a contributing factor; "make things factor into a companys profitability"
21. any of the numbers (or symbols) that form a product when multiplied together
22. an independent variable in statistics
23. anything that contributes causally to a result; "a number of factors determined the outcome"
24. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
25. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
26. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
27. a concept whose truth can be proved; "scientific hypotheses are not facts"
28. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
29. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. (時間・時期が)『早い』,『初期の』 / 昔の / (普通より,予定より)早い / 近い将来の / (時間・時期的に)『早く』 / (予定・ふだんより)早く
2. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
3. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
4. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
5. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/27 09:38:38」(JST)

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Early growth response 2
PDB rendering based on 1a1i.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1a1i, 1a1j, 1a1k, 1a1l, 1aay, 1jk1, 1jk2, 1p47, 1zaa
Identifiers
Symbols	EGR2 ; AT591; CMT1D; CMT4E; KROX20
External IDs	OMIM: 129010 MGI: 95296 HomoloGene: 20123 GeneCards: EGR2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II activating transcription factor binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • ligase activity • ubiquitin protein ligase binding • transcription regulatory region DNA binding • metal ion binding • HMG box domain binding Cellular component • nucleus • cytoplasm Biological process • transcription from RNA polymerase II promoter • protein export from nucleus • brain development • peripheral nervous system development • learning or memory • rhythmic behavior • motor neuron axon guidance • Schwann cell differentiation • protein sumoylation • facial nerve structural organization • rhombomere 3 formation • rhombomere 5 formation • regulation of ossification • response to insulin • brain segmentation • skeletal muscle cell differentiation • myelination • negative regulation of apoptotic process • fat cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of neuronal synaptic plasticity • cellular response to cAMP • cellular response to gonadotropin stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1959	13654
Ensembl	ENSG00000122877	ENSMUSG00000037868
UniProt	P11161	P08152
RefSeq (mRNA)	NM_000399	NM_010118
RefSeq (protein)	NP_000390	NP_034248
Location (UCSC)	Chr 10: 62.81 – 62.92 Mb	Chr 10: 67.54 – 67.54 Mb
PubMed search	[1]	[2]

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.

Function

The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1D, Dejerine–Sottas disease, and Congenital Hypomyelinating Neuropathy. Two studies have linked EGR2 expression to proliferation of osteoprogenitors and cell lines derived from Ewing sarcoma, which is a highly aggressive bone-associated cancer.

References

Further reading

• Rangnekar VM, Aplin AC, Sukhatme VP (May 1990). "The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein". Nucleic Acids Research 18 (9): 2749–57. doi:10.1093/nar/18.9.2749. PMC 330760. PMID 2111009. 
• Chavrier P, Janssen-Timmen U, Mattéi MG, Zerial M, Bravo R, Charnay P (Feb 1989). "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology 9 (2): 787–97. PMC 362656. PMID 2496302. 
• Joseph LJ, Le Beau MM, Jamieson GA, Acharya S, Shows TB, Rowley JD, Sukhatme VP (Oct 1988). "Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure". Proceedings of the National Academy of Sciences of the United States of America 85 (19): 7164–8. doi:10.1073/pnas.85.19.7164. PMC 282144. PMID 3140236. 
• Topilko P, Schneider-Maunoury S, Levi G, Baron-Van Evercooren A, Chennoufi AB, Seitanidou T, Babinet C, Charnay P (Oct 1994). "Krox-20 controls myelination in the peripheral nervous system". Nature 371 (6500): 796–9. doi:10.1038/371796a0. PMID 7935840. 
• Sham MH, Vesque C, Nonchev S, Marshall H, Frain M, Gupta RD, Whiting J, Wilkinson D, Charnay P, Krumlauf R (Jan 1993). "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation". Cell 72 (2): 183–96. doi:10.1016/0092-8674(93)90659-E. PMID 8093858. 
• Levi G, Topilko P, Schneider-Maunoury S, Lasagna M, Mantero S, Pesce B, Ghersi G, Cancedda R, Charnay P (Jun 1996). "Role of Krox-20 in endochondral bone formation". Annals of the New York Academy of Sciences 785: 288–91. doi:10.1111/j.1749-6632.1996.tb56286.x. PMID 8702157. 
• Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (Apr 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics 18 (4): 382–4. doi:10.1038/ng0498-382. PMID 9537424. 
• Warner LE, Svaren J, Milbrandt J, Lupski JR (Jul 1999). "Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies". Human Molecular Genetics 8 (7): 1245–51. doi:10.1093/hmg/8.7.1245. PMID 10369870. 
• Timmerman V, De Jonghe P, Ceuterick C, De Vriendt E, Löfgren A, Nelis E, Warner LE, Lupski JR, Martin JJ, Van Broeckhoven C (Jun 1999). "Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype". Neurology 52 (9): 1827–32. doi:10.1212/wnl.52.9.1827. PMID 10371530. 
• Bellone E, Di Maria E, Soriani S, Varese A, Doria LL, Ajmar F, Mandich P (Oct 1999). "A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease". Human Mutation 14 (4): 353–4. doi:10.1002/(SICI)1098-1004(199910)14:4<353::AID-HUMU17>3.0.CO;2-4. PMID 10502832. 
• Pareyson D, Taroni F, Botti S, Morbin M, Baratta S, Lauria G, Ciano C, Sghirlanzoni A (Apr 2000). "Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation". Neurology 54 (8): 1696–8. doi:10.1212/wnl.54.8.1696. PMID 10762521. 
• Gambardella L, Schneider-Maunoury S, Voiculescu O, Charnay P, Barrandon Y (Sep 2000). "Pattern of expression of the transcription factor Krox-20 in mouse hair follicle". Mechanisms of Development 96 (2): 215–8. doi:10.1016/S0925-4773(00)00398-1. PMID 10960786. 
• Yoshihara T, Kanda F, Yamamoto M, Ishihara H, Misu K, Hattori N, Chihara K, Sobue G (Mar 2001). "A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1". Journal of the Neurological Sciences 184 (2): 149–53. doi:10.1016/S0022-510X(00)00504-9. PMID 11239949. 
• Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (Jul 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. 
• Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". The Journal of Biological Chemistry 277 (22): 19482–7. doi:10.1074/jbc.M201687200. PMID 11909874. 
• Vandenberghe N, Upadhyaya M, Gatignol A, Boutrand L, Boucherat M, Chazot G, Vandenberghe A, Latour P (Dec 2002). "Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies". Journal of Medical Genetics 39 (12): e81. doi:10.1136/jmg.39.12.e81. PMC 1757229. PMID 12471219. 
• Musso M, Balestra P, Taroni F, Bellone E, Mandich P (Feb 2003). "Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter". Neurobiology of Disease 12 (1): 89–95. doi:10.1016/S0969-9961(02)00018-9. PMID 12609493. 
• Unoki M, Nakamura Y (Apr 2003). "EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK". Oncogene 22 (14): 2172–85. doi:10.1038/sj.onc.1206222. PMID 12687019. 
• Numakura C, Shirahata E, Yamashita S, Kanai M, Kijima K, Matsuki T, Hayasaka K (Jun 2003). "Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1". Journal of the Neurological Sciences 210 (1-2): 61–4. doi:10.1016/S0022-510X(03)00028-5. PMID 12736090. 

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1
• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4
• EGR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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• 1. 成長ホルモンの生理学 physiology of growth hormone
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English Journal

• Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.

• Zheng Y, Zha Y, Spaapen RM, Mathew R, Barr K, Bendelac A, Gajewski TF.SourceDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA.
• Molecular immunology.Mol Immunol.2013 Oct;55(3-4):283-91. doi: 10.1016/j.molimm.2013.03.006. Epub 2013 Mar 30.
• T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for
• PMID 23548837

• A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages.

• Lagrange B, Martin RZ, Droin N, Aucagne R, Paggetti J, Largeot A, Itzykson R, Solary E, Delva L, Bastie JN.SourceInserm U866, Labex LipSTIC team, Faculté de Médecine, Université de Bourgogne, 21000 Dijon, France.
• Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1833(8):1936-46. doi: 10.1016/j.bbamcr.2013.04.007. Epub 2013 Apr 17.
• The differentiation of human peripheral blood monocytes into macrophages can be reproduced ex vivo by culturing the cells in the presence of colony-stimulating factor 1 (CSF1). Using microarray profiling to explore the role of microRNAs (miRNAs), we identified a dramatic decrease in the expression o
• PMID 23602969

• Increased expression of p21Waf1/Cip1 and JNK with costimulation of prostate cancer cell activation by an siRNA Egr-1 inhibitor.

• Parra E, Gutiérrez L, Ferreira J.SourceLaboratory of Experimental Biomedicine, University of Tarapaca, Campus Esmeralda, Iquique, Chile.
• Oncology reports.Oncol Rep.2013 Aug;30(2):911-6. doi: 10.3892/or.2013.2503. Epub 2013 May 28.
• The p21Waf1/Cip1 protein (hereafter, p21) and the c‑Jun N-terminal kinase (JNK) are two well-characterized cell modulators that play a crucial role in cell differentiation, senescence and apoptosis. Here, we report that transcription of the p21Waf1/Cip1 and JNK-1 genes is affected by inhibition o
• PMID 23715767

Japanese Journal

• OA軟骨細胞におけるGadd45betaの発現と機能

• 井尻 幸成,嶋田 博文,土持 兼之,小宮 節郎
• 日本関節病学会誌 32(2), 83-87, 2013
• … Gadd45beta is known to be associated with cell growth control, apoptosis, and the cellular response to DNA damage. … Gadd45beta was expressed at higher levels in cartilage from normal donors and patients with early osteoarthritis (OA) than in cartilage from patients with late-stage OA. … In early OA, Gadd45beta was distributed variably in chondrocyte clusters, in middle and deep zone cells and in osteophytes. …
• NAID 130004688984

• Transcriptional regulation of the human bone sialoprotein gene by fibroblast growth factor 2

• Zhou Liming,Ogata Yorimasa
• Journal of Oral Science 55(1), 63-70, 2013
• … Fibroblast growth factor 2 (FGF2), a member of the FGF family, positively regulates bone formation and osteoblast differentiation. … Bone sialoprotein (BSP) is highly expressed during early bone formation and may play a role in primary mineralization of bone. … The results of gel shift assays showed that FGF2 (10 ng/mL) increased the binding of nuclear protein to the FGF2 response element (FRE) and the activator protein 1 (AP1) binding site. …
• NAID 130003366653

• Cardamonin Suppresses the Proliferation of Colon Cancer Cells by Promoting β-Catenin Degradation

• Park Seoyoung,Gwak Jungsug,Han Seung Jin [他],Oh Sangtaek
• Biological and Pharmaceutical Bulletin 36(6), 1040-1044, 2013
• … Aberrant accumulation of intracellular β-catenin and subsequent activation of β-catenin response transcription (CRT) in intestinal epithelial cells is a frequent early event during the development of colon cancer. … In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known β-catenin/T cell factor (TCF)-dependent genes. …
• NAID 130003361462

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★リンクテーブル★

リンク元	「EGR transcription factor」「初期増殖応答転写因子」
関連記事	「early」「grow」「fact」「factor」「transcription factor」

「EGR transcription factor」

　　[★]

初期増殖応答転写因子

関

early growth response transcription factor

「初期増殖応答転写因子」

　　[★]

英

early growth response transcription factor、EGR transcription factor

「early」

　　[★]

• adj.

• (比較級earlier-最上級earliest)早期の、初期の

• adv.

• 早く

関

archaic、beginning、early stage、early-stage、initial、initially、preterm、soon

　 　 　 　 　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「transcription factor」

　　[★]

• 転写制御因子、転写因子

関

TF、transcriptional regulator、transcriptional regulatory element