WordNet
- suffer or be susceptible to damage; "These fine china cups damage easily"
- inflict damage upon; "The snow damaged the roof"; "She damaged the car when she hit the tree"
- the act of damaging something or someone (同)harm, hurt, scathe
- loss of military equipment (同)equipment casualty
- the occurrence of a change for the worse (同)harm, impairment
- of or relating to the cerebrum or brain; "cerebral hemisphere"; "cerebral activity"
- involving intelligence rather than emotions or instinct; "a cerebral approach to the problem"; "cerebral drama" (同)intellectual
- designed or tending to discredit, especially without positive or helpful suggestions; "negative criticism" (同)negative
- (sometimes followed by `to' (同)detrimental, prejudicial, prejudicious
- harmed or injured or spoiled; "I wont buy damaged goods"; "the storm left a wake of badly damaged buildings"
- a sum of money paid in compensation for loss or injury (同)amends, indemnity, indemnification, restitution, redress
PrepTutorEJDIC
- 〈U〉『損害』,損傷,被害 / 《複数形で》損害賠障[金] / 《the~》《単数形で》《話》飛用 / …‘に'損傷する
- 大脳の,脳の / 頭脳的な,知的な
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- 1. 動脈瘤性くも膜下出血の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of aneurysmal subarachnoid hemorrhage
- 2. 新生児における脳卒中 stroke in the newborn
- 3. 虚血性脳卒中の病態生理 pathophysiology of ischemic stroke
- 4. 中枢神経系の原発性血管炎 primary angiitis of the central nervous system
- 5. 悪性中大脳動脈領域梗塞に対する減圧開頭術 decompressive hemicraniectomy for malignant middle cerebral artery territory infarction
English Journal
- Proinflammatory cytokines in the embolic model of cerebral ischemia in rat.
- Jafarinaveh HR, Allahtavakoli M, Rezazadeh H, Kazemi Arababadi M, Taghavi MM, Shamsizadeh A, Rahmani MR.Author information Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. rahmanir47@yahoo.com.AbstractIncreased levels of proinflammatory cytokines have been recorded after the onset of transient or permanent brain ischemia and are usually associated with exacerbation of ischemic injury. Embolic stroke model is more relevant to the pathophysiological situation in such patients, because the majority of ischemic injuries in humans are induced by old thrombi that originate from the heart and carotid arteries. Therefore, the aim of the present study was to investigate changes of inflammatory cytokines after embolic stroke. Rats were subjected to embolic stroke, induced by a natural old clot which was injected in Middle Cerebral Artery (MCA), or sham stroke, which the same volume of saline was injected into the MCA. At 48 h after stroke induction, the levels of 5 cytokines (IL-1α and β, IL-6, IFN-γ and TNF-α) were determined in 500 µg of total protein using the Bio-Plex Rat Cytokine Array (BioRad), according to the manufacturer's instructions in ischemic and non-ischemic cortices. While stroke animals showed infarctions and neurological deficits, we did not observe any cerebral infarction and neurological deficits in sham-operated animals. The levels of IL-1α (p=0.000) and -β (p =0.004), IL-6 (p =0.008), TNF-α (p =0.000) and IFN-γ (p =0.044) were significantly increased compared to sham treated animals. The findings of the present study suggest that part of ischemic injury in the embolic stroke may be mediated through the increased levels of inflammatory cytokines.
- Iranian journal of allergy, asthma, and immunology.Iran J Allergy Asthma Immunol.2014 Apr;13(2):125-30.
- Increased levels of proinflammatory cytokines have been recorded after the onset of transient or permanent brain ischemia and are usually associated with exacerbation of ischemic injury. Embolic stroke model is more relevant to the pathophysiological situation in such patients, because the majority
- PMID 24338258
- A new method to assess weight-bearing distribution after central nervous system lesions in rats.
- Pertici V1, Pin-Barre C2, Felix MS1, Laurin J3, Brisswalter J2, Decherchi P1.Author information 1Aix-Marseille Université (AMU) et Centre National de la Recherche Scientifique (CNRS), UMR 7287 «Institut des Sciences du Mouvement (ISM): Etienne-Jules MAREY», Equipe «Plasticité des Systèmes Nerveux et Musculaire» (PSNM), Parc Scientifique et Technologique de Luminy, Faculté des Sciences du Sport de Marseille, CC910 - 163 Avenue de Luminy, F-13288 Marseille cedex 09, France.2Université de Nice Sophia-Antipolis et Université du Sud Toulon Var, EA 6309 «Motricité Humaine Éducation Sport Santé» (LAMHESS), UFR STAPS de Nice, 261, route de Grenoble, F-06205 Nice, France.3Aix-Marseille Université (AMU) et Centre National de la Recherche Scientifique (CNRS), UMR 7287 «Institut des Sciences du Mouvement (ISM): Etienne-Jules MAREY», Equipe «Plasticité des Systèmes Nerveux et Musculaire» (PSNM), Parc Scientifique et Technologique de Luminy, Faculté des Sciences du Sport de Marseille, CC910 - 163 Avenue de Luminy, F-13288 Marseille cedex 09, France. Electronic address: jerome.laurin@univ-amu.fr.AbstractThe aim of the present study is to assess the relevance of weight-bearing distribution (DWB) measurement in freely moving rats after stroke and thoracic spinal cord injuries. Animals were divided in 2 experiments: (1) The middle cerebral artery occlusion-reperfusion (MCAO-r) experiment containing the MCAO group in which focal brain ischaemia was induced by transient MCA occlusion and (2) the thoracic hemisection experiment containing the TH group in which a spinal cord hemisection was performed at the T10 level. A Control and respective Sham groups were also included in each experiment. Not only the pressure exerted by each paw was measured but also different ratios such as: (1) the sum of the right and the left forepaws was normalized by the sum of the right and the left hindpaws (F/H), (2) the left forepaw was normalized by the right forepaw (LF/RF), (3) the left hindpaw was normalized by the right hindpaw (LH/RH). Additionally, the times spent on 3 paws and on 4 paws were measured. Only the time spent on 4 paws was shorter in the MCAO group than in the Control (p<0.001) and in the Sham (p<0.01) groups. The LH/RH ratio of the TH group at the 1st week was lower (p<0.01) than the pre-surgical value. Moreover, its F/H ratio was superior (p<0.001) to the ones of the Control and the Sham groups. Our study indicates that DWB should be more frequently used to evaluate both the severity of central nervous system traumas and the effectiveness of pharmacological and/or rehabilitation strategies.
- Behavioural brain research.Behav Brain Res.2014 Feb 1;259:78-84. doi: 10.1016/j.bbr.2013.10.043. Epub 2013 Nov 4.
- The aim of the present study is to assess the relevance of weight-bearing distribution (DWB) measurement in freely moving rats after stroke and thoracic spinal cord injuries. Animals were divided in 2 experiments: (1) The middle cerebral artery occlusion-reperfusion (MCAO-r) experiment containing th
- PMID 24200548
- Behavioral and histological outcomes following neonatal HI injury in a preterm (P3) and term (P7) rodent model.
- Alexander M1, Garbus H2, Smith AL2, Rosenkrantz TS3, Fitch RH2.Author information 1University of Connecticut, Department of Psychology, 406 Babbidge Road, Unit 1020, Storrs, CT 06269, USA. Electronic address: alex0213@umn.edu.2University of Connecticut, Department of Psychology, 406 Babbidge Road, Unit 1020, Storrs, CT 06269, USA.3University of Connecticut Health Center, Department of Pediatrics, 263 Farmington Ave, Farmington, CT 06030, USA.AbstractHypoxia-ischemia (HI) occurs when blood and/or oxygen delivery to the brain is compromised. HI injuries can occur in infants born prematurely (<37 weeks gestational age) or at very low birth weight (<1500g), as well as in term infants with birth complications. In both preterm and term HI populations, brain injury is associated with subsequent behavioral deficits. Neonatal HI injury can be modeled in rodents (e.g., the Rice-Vannucci method, via cautery of right carotid followed by hypoxia). When this injury is induced early in life (between postnatal day (P)1-5), neuropathologies typical of human preterm HI are modeled. When injury is induced later (P7-12), neuropathologies typical of those seen in HI term infants are modeled. The current study sought to characterize the similarities/differences between outcomes following early (P3) and late (P7) HI injury in rats. Male rats with HI injury on P3 or P7, as well as sham controls, were tested on a variety of behavioral tasks in both juvenile and adult periods. Results showed that P7 HI rats displayed deficits on motor learning, rapid auditory processing (RAP), and other learning/memory tasks, as well as a reduction in volume in various neuroanatomical structures. P3 HI animals showed only transient deficits on RAP tasks in the juvenile period (but not in adulthood), yet robust deficits on a visual attention task in adulthood. P3 HI animals did not show any significant reductions in brain volume that we could detect. These data suggest that: (1) behavioral deficits following neonatal HI are task-specific depending on timing of injury; (2) P3 HI rats showed transient deficits on RAP tasks; (3) the more pervasive behavioral deficits seen following P7 HI injury were associated with substantial global tissue loss; and (4) persistent deficits in attention in P3 HI subjects might be linked to neural connectivity disturbances rather than a global loss of brain volume, given that no such pathology was found. These combined findings can be applied to our understanding of differing long-term outcomes following neonatal HI injury in premature versus term infants.
- Behavioural brain research.Behav Brain Res.2014 Feb 1;259:85-96. doi: 10.1016/j.bbr.2013.10.038. Epub 2013 Nov 1.
- Hypoxia-ischemia (HI) occurs when blood and/or oxygen delivery to the brain is compromised. HI injuries can occur in infants born prematurely (<37 weeks gestational age) or at very low birth weight (<1500g), as well as in term infants with birth complications. In both preterm and term HI popul
- PMID 24185032
Japanese Journal
- 両側の血腫除去術を要した頭部外傷8症例の臨床的検討
- 大渕 英徳,萩原 信司,菊池 麻美 [他],高橋 祐一,吉村 知香,横佐古 卓,新井 直幸,黒井 康博,広田 健吾,笹原 篤,谷 茂,糟谷 英俊
- 東京女子医科大学雑誌 84(1), 9-12, 2014-02-25
- (はじめに)頭部外傷において、短時間の間に両側の血腫除去術を要する例は稀である。今回我々は受傷後12時間以内に両側の血腫除去術を行った頭部外傷8症例について臨床的検討を行った。(対象)過去10年間に女子医大東医療センターで外傷性頭蓋内血腫除去術を行った168症例のうち、受傷後12時間以内に両側の頭蓋内血腫除去術を行なった8症例(4.8%)を対象とした。(結果)症例の内訳は男性4例、女性4例。受傷機 …
- NAID 110009676512
- 虚血性ペナンブラにおける分子病理
- 猪瀬 悠理,柴田 亮行,内山 真一郎
- 東京女子医科大学雑誌 84(E1), E91-E101, 2014-01-31
- 脳梗塞発生後数時間以上が経過すると、病巣中心部に不可逆的な凝固壊死巣(コア)が出現し、その周囲を、血流が低下しているにもかかわらずニューロンがまだ生存している可逆的辺縁帯(ペナンブラ相当領域)が取り巻くようになる.ペナンブラ相当領域では、ニューロンとグリアの相互作用がニューロンの生死を決定づける実験的証拠が集積されつつある.細胞マーカーを用いてヒト急性期脳梗塞巣を免疫組織化学染色してみると、ペナン …
- NAID 110009752560
- 認知機能の加齢性変化と認知予備能
- 吉澤 浩志,内山 真一郎
- 東京女子医科大学雑誌 84(E1), E57-E65, 2014-01-31
- 他の身体機能と同様に脳神経系は加齢により変化を余儀なくされ、認知機能もそれに伴って低下する。しかし認知機能の低下は一様ではなく、認知機能の下位ドメインによって相対的に保たれる機能と、加齢に対して脆弱な機能に分けられる。脳は構造的にも機能的にも老化の影響を受け、さまざまな画像検査によってその変化が検出される。また死亡時にAlzheimer病や脳梗塞、外傷性脳損傷などの脳の病理過程を有していても、生前 …
- NAID 110009752555
Related Links
- Brain damage. From Wikipedia, the free encyclopedia. Jump to: navigation, search. For other uses, see brain damage (disambiguation) and Brain injury. ... " Brain damage" or "brain injury" (BI) is the destruction or degeneration of brain cells.
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★リンクテーブル★
| リンク元 | 「brain damage」 |
| 関連記事 | 「damage」「cerebral」「damaged」 |
「brain damage」
「damage」
- n.
- v.
- 破損する、損傷する
- 関
- barrier、break、breakage、difficulty、disorder、disruption、disturbance、dysfunction、foe、hindrance、impair、impairment、impediment、injure、injury、lesion、obstacle、spoilage
「cerebral」
- adj.
- 大脳の、大脳性の、脳性の、脳の
「damaged」
- adj.
- 傷害性の