WordNet
- part with a possession or right; "I am relinquishing my bedroom to the long-term house guest"; "resign a claim to the throne" (同)relinquish, resign, free, give_up
- a process that liberates or discharges something; "there was a sudden release of oxygen"; "the release of iodine from the thyroid gland"
- a device that when pressed will release part of a mechanism (同)button
- activity that frees or expresses creative energy or emotion; "she had no other outlet for her feelings"; "he gave vent to his anger" (同)outlet, vent
- (music) the act or manner of terminating a musical phrase or tone (同)tone ending
- a formal written statement of relinquishment (同)waiver, discharge
- merchandise issued for sale or public showing (especially a record or film); "a new release from the London Symphony Orchestra"
- release (gas or energy) as a result of a chemical reaction or physical decomposition (同)free, liberate
- reason or establish by induction
- cause to arise; "induce a crisis" (同)bring_on
- produce electric current by electrostatic or magnetic processes (同)induct
- cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
- cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
- a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
- brought about or caused; not spontaneous; "a case of steroid-induced weakness"
PrepTutorEJDIC
- (束縛・義務などから)〈人・動物など〉‘を'『自由にする』,解放する《+『名』+『from』+『名』》 / 〈矢など〉‘を'放つ,〈爆弾〉‘を'投下する;〈締めつけた物〉‘を'ゆるめて放す / 〈ニュースなど〉‘を'発表する;〈レコード・書籍など〉‘を'発売する,〈映画〉‘を'封切りする / (人に)〈権利など〉‘を'譲渡する《+『名』+『to』+『名』》 / (束縛・義務などからの)『解放』,放免,免除《+『from』+『名』》 / (ガスなどの)放出;(爆弾の)投下;(感情の)吐露《+『of』(『to』)+『名』》 / (ニュースなどの)発表;(映画などの)封切り,(レコードなどの)発表 / (機械の)作動装置,レリーズ
- 〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
- 『カルシウム』(金属元素;化学記号は『Ca』)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/03/07 11:53:11」(JST)
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Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca2+ stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s,[1] it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle[2] and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells[3] and many other cells. Since CICR is a positive-feedback system, it has been of great interest to elucidate the mechanism(s) responsible for its termination.
Examples in Biology
Excitation-contraction coupling
Excitation-contraction coupling in myocardium relies on sarcolemma depolarization & subsequent Ca2+ entry to trigger Ca2+ release from the sarcoplasmic reticulum. When an action potential depolarizes the cell membrane, voltage-gated Ca2+ channels (e.g., L-type calcium channels) are activated. CICR occurs when the resulting Ca2+ influx activates ryanodine receptors on the SR membrane, which causes more Ca2+ to be released into the cytosol. In cardiac muscle, the result of CICR is observed as a spatio-temporally restricted Ca2+ spark. The result of CICR across the cell causes the significant increase in cytosolic Ca2+ that is important in activating muscle contraction.
References
- ^ Endo, M (1977). "Calcium release from the sarcoplasmic reticulum". Physiological reviews. 57 (1): 71–108. PMID 13441.
- ^ Fabiato, A. (1983). "Calcium-induced calcium release from the cardiac sarcoplasmic reticulum". American Journal of Physiology. 245 (1): C1–14. PMID 6346892.
- ^ Islam, Md.Shahidul; Rorsman, Patrik; Berggren, Per-Olof (1992). "Ca2+-induced Ca2+ release in insulin-secreting cells". FEBS Letters. 296 (3): 287–91. doi:10.1016/0014-5793(92)80306-2. PMID 1537406.
Cell signaling: calcium signaling and calcium metabolism
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Cell membrane |
Ion pumps
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- SERCA
- Sodium-calcium exchanger
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Cell membrane calcium channels
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- VDCC
- TRP
- NMDA receptor
- AMPA receptor
- 5-HT3 receptor
- P2X purinoreceptor
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Adhesion molecules
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Other
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Intracellular signaling
& calc. regulation |
Second messengers
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Store gates
(ligand-gated calcium channel)
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Molecular switches, and kinases
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- Troponin C
- Calmodulin
- CaM kinases
- PKC
- NCS
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Chelators and calcium sensors
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- Calbindin
- S100
- pervalbumin
- Calretinin
- Calsequestrin
- Sarcalumenin
- Phospholamban
- Synaptotagmins
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Proteases
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Cytoskeleton remodeling proteins
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Chaperones
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Other
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Calcium-binding
protein domains |
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Extracellular ligands |
- Parathyroid hormone
- Calcitonin
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Calcium-binding proteins |
Intracellular calcium-sensing proteins
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- Calmodulin
- Calnexin
- Calreticulin
- Gelsolin
- neuronal
- Hippocalcin
- Neurocalcin
- Recoverin
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Membrane protein
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- Vitamin D-dependent calcium-binding protein/Calbindin
- Calexcitin
- Calsequestrin
- Osteocalcin
- Osteonectin
- S-100
- Synaptotagmin
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Cytoskeleton
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Extracellular matrix
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UpToDate Contents
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English Journal
- Effect of Andrographolide on Gene Expression Profile and Intracellular Calcium in Primary Rat Myocardium Microvascular Endothelial Cells.
- Feng B1, Zhang Q, Wang X, Sun X, Mu X, Dong H.
- Journal of cardiovascular pharmacology.J Cardiovasc Pharmacol.2017 Oct 31. doi: 10.1097/FJC.0000000000000528. [Epub ahead of print]
- PMID 29112590
- Thyroid and Glucocorticoid Hormones Promote Functional T-tubule Development in Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes.
- Parikh SS1, Blackwell DJ2, Gomez-Hurtado N3, Frisk M4, Wang L1, Kim K2, Dahl CP5, Fiane AE6, Tønnessen T6, Kryshtal DO2, Louch WE4, Knollmann BC7.
- Circulation research.Circ Res.2017 Oct 2. pii: CIRCRESAHA.117.311920. doi: 10.1161/CIRCRESAHA.117.311920. [Epub ahead of print]
- PMID 28974554
- Kinetic coupling of phosphate release, force generation and rate-limiting steps in the cross-bridge cycle.
- Stehle R1, Tesi C2.
- Journal of muscle research and cell motility.J Muscle Res Cell Motil.2017 Sep 16. doi: 10.1007/s10974-017-9482-8. [Epub ahead of print]
- PMID 28918606
Japanese Journal
- Calcium-induced calcium release from the sarcoplasmic reticulum can be evaluated with a half-logistic function model in aequorin-injected cardiac muscles
- MIZUNO Ju,HANAOKA Kazuo,OTSUJI Mikiya,ARITA Hideko,SAKAMOTO Hidetoshi,FUKUDA Satoru,SAWAMURA Shigehito
- Journal of anesthesia 25(6), 831-838, 2011-12-20
- NAID 10030448692
- 村田 慶史,中村 倫子,小藤 恭子 [他],磯部 隆史,岸 利弘
- 日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology 58(9), 428-432, 2011-09-15
- α-リポ酸(ALA)を用いたキトサンの塩,CS-ALAを調製し,一次胆汁酸あるいは二次胆汁酸の吸着,並びにALA放出挙動を調べた.また,CA-ALAを含有したアルギン酸カルシウムゲルビーズ(Alg-Ca)の調製と経口摂取用の担体としての機能についても検討した.一次胆汁酸であるタウロコール酸の溶液中において,CS-ALAはALAを放出すると同時にその胆汁酸を吸着し,また,二次胆汁酸のタウロデオキシコ …
- NAID 10029722638
Related Links
- Calcium-induced calcium release (CICR) has been observed in cardiac myocytes as elementary calcium release events (calcium sparks) associated with the opening of L-type Ca 2+ channels. In heart cells, a tight coupling between ...
- Why is calcium so important? Intracellular calcium controls a diverse array of cellular processes from fertilisation through gene transcription, muscle contraction to cell death. Changes in calcium levels can occur in microseconds or ...
Related Pictures
★リンクテーブル★
[★]
- 英
- calcium-induced calcium release、Ca2+-induced Ca2+ release、CICR
- 関
- Ca2+誘発Ca2+遊離
-CICR
- 関
- See Calcium-induced calcium release
[★]
- 関
- calcium-induced calcium release、CICR
- 同
- CICR
[★]
- 関
- Ca2+-induced Ca2+ release、calcium-induced calcium release
[★]
- 誘発する、誘導する、誘起する、導入する、引き起こす
- 関
- cause、challenge、derivation、elicit、elicitation、evocation、evoke、guidance、induction、inductive、introduce、introduction、precipitate、provocation、provoke、spark
[★]
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- hypercalcaemia induced pancreatitis 高カルシウム血症による膵炎
[★]
[★]