Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/08 02:17:37」(JST)

wiki en

Betamethasone is a steroid medication.^[1] It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby, Crohn disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others.^[1] It can be taken by mouth, injected into a muscle, or applied as a cream.^[1]^[2] When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.^[1]

Serious side effects include an increased risk of infection, muscle weakness, severe allergic reactions, and psychosis. Long term use may cause adrenal insufficiency. Stopping the medication suddenly following long term use may be dangerous.^[1] The cream commonly results in increased hair growth and skin irritation.^[2] Betamethasone belongs to the glucocorticoid class of medication.^[1]

Betamethasone was approved for medical use in the United States in 1961.^[1] The cream is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.^[3] It is available as a generic medication.^[1] In the United States the pills and injectable solution are expensive while the cream is not.^[4]

Medical uses

Betamethasone is a corticosteroid that is available as pill, by injection, and as a cream.

It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals, include the steroid as the valerate ester.

In a randomized controlled trial Betamethasone was shown to reduce some of the ataxia symptoms associated with Ataxia Telangiectasia (A-T) by 28-31%.^[5]

Alternative medical approach for large microcystic CCAMs – Betamethasone therapy^{[citation needed]}

Betamethasone is also used prior to delivery of a preterm baby to help prepare the lung for breathing.

Steroids such as betamethasone are also used to treat phimosis (tight foreskin) in males.^[6]

Side effects

Skin irritation, e.g. itching, burning, stinging.
Thinning of the skin.
Changes in skin pigmentation and coloration.
Stretch marks (striae).
Groupings of fine blood vessels becoming prominent under the skin (telangiectasia).
Excessive hair growth (hypertrichosis).

Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the adrenal glands.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision.^[7]^[8]^[9] It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.^[10]^[11]

Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.^{[citation needed]}

Forms

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort in Pakistan and others), sodium phosphate (branded as Bentelan in Italy^[12]) and valerate (branded as Audavate, Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid for using in psoriatic skin conditions. In Mexico it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix.

References

^ ^a ^b ^c ^d ^e ^f ^g ^h "Betamethasone". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.
^ ^a ^b "Betamethasone topical". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.
^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 186,201. ISBN 9781284057560.
^ Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders : official journal of the Movement Disorder Society 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201.
^ Moreno, G; Corbalán, J; Peñaloza, B; Pantoja, T (2 September 2014). "Topical corticosteroids for treating phimosis in boys.". The Cochrane database of systematic reviews 9: CD008973. PMID 25180668.
^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.
^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650.
^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.
^ http://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN

External links

"Betamethasone". safefetus.com.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 早産による新生児の罹病および死亡を減少させるための出産前ステロイド療法 antenatal corticosteroid therapy for reduction of neonatal morbidity and mortality from preterm delivery
2. クループ：薬剤および補助治療 croup pharmacologic and supportive interventions
3. Diagnosis of preterm labor and overview of preterm birth
4. 包皮非切除者の陰茎のケア care of the uncircumcised penis
5. 乾癬の治療 treatment of psoriasis

English Journal

Seborrhoeic dermatitis of the scalp.

Naldi L1, Diphoorn J.
BMJ clinical evidence.BMJ Clin Evid.2015 May 27;2015. pii: 1713.
INTRODUCTION: Seborrhoeic dermatitis affects a variable proportion of the general population, ranging from 3% to 10%. Malassezia yeast species (previously referred to as Pityrosporum) are thought to be the responsible organisms, and cause inflammation by still poorly defined mechanisms. Seborrhoeic
PMID 26016669

Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry.

Isobe T1, Sato K, Joon-Woo K, Tanabe S, Suzuki G, Nakayama K.
Environmental science and pollution research international.Environ Sci Pollut Res Int.2015 May 13. [Epub ahead of print]
A sensitive and comprehensive analytical method for glucocorticoids (GCs) in water samples was developed and applied to effluent of sewage treatment plants (STPs). In the present study, totally 10 natural and synthetic GCs, including cortisol, betamethasone valerate, clobetasol propionate, clobetaso
PMID 25963071

Japanese Journal

Determination of Selected Corticosteroids in Sewage-treatment-plant Samples by Liquid Chromatography-mass Spectrometry

Kitaichi Yuko,Miyamoto Aoi,Uchikura Kazuo
JOURNAL OF HEALTH SCIENCE 56(5), 547-556, 2010
… The compounds studied were prednisolone, dexamethasone, betamethasone, triamcinolone acetonide, fluocinolone acetonide, prednisolone acetate, hydrocortisone acetate, betamethasone valerate, and betamethasone dipropionate. …
NAID 130000425090

「ベタメタゾン」

Betamethasone
Systematic (IUPAC) name
	(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
Clinical data
Trade names	Celestone
AHFS/Drugs.com	monograph
Pregnancy; category	US: C (Risk not ruled out); ;
Routes of; administration	Oral,Topical,IM
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic CYP3A4
Biological half-life	36-54 hours
Excretion	Renal (in urine)
Identifiers
CAS Number	378-44-9
ATC code	A07EA04 C05AA05 D07AC01 H02AB01 R01AD06 R03BA04 S01BA06 S02BA07 S03BA03
PubChem	CID 9782
IUPHAR/BPS	7061
DrugBank	DB00443
ChemSpider	9399
UNII	9842X06Q6M
KEGG	D00244
ChEBI	CHEBI:3077
ChEMBL	CHEMBL632
Chemical data
Formula	C22H29FO5
Molar mass	392.461
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C ;
	InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 ; Key:UREBDLICKHMUKA-DVTGEIKXSA-N ;
(verify)

　　[★]

英: betamethasone
同: ベタメサゾン
化: ベタメタゾンリン酸エステルナトリウム、リン酸ベタメタゾンナトリウム betamethasone sodium phosphate; 酢酸ベタメタゾン betamethasone acetate; 吉草酸ベタメタゾン betamethasone valerate。ベタメタゾン吉草酸エステル; ベタメタゾンジプロピオン酸エステル、ジプロピオン酸ベタメタゾン betamethasone dipropionate; ベタメタゾン酪酸エステルプロピオン酸エステル
商: リンデロン Rinderon、アンテベート。Celestone; アンテベート、アンフラベート、エンペラシン、ケリグロール、サクコルチン、サレックス、サンベタゾン、ステロネマ、セレスタミン、ダイプロセル、ディーピーポロン、デキサンVG、デルモゾールＤＰ、デルモゾールＧ、デルモゾール、トクダーム、トチプロベタゾン、ノルコット、ハイコート、ヒスタブロック、ヒズボット、フロダーム、プラデスミン、ベクトミラン、ベタセレミン、ベトネベートＮ、ベトネベート、ベトノバールＧ、ベルベゾロンF、ベルベゾロン、リダスロン、リネステロン、リノロサール、リンデロン-DP、リンデロン-VG、リンデロン-V、リンデロン、リンベタPF、ルリクールVG、リンデロンA
関: 鎮痛，鎮痒，収歛，消炎剤

GOO.1594

Table 59–2 Relative Potencies and Equivalent Doses of Representative Corticosteroids
COMPOUND	ANTIINFLAMMATORY POTENCY	Na+-RETAINING POTENCY	DURATION OF ACTION	EQUIVALENT DOSE, MG
prednisone	4	0.8	I	5
prednisolone	4	0.8	I	5
betamethasone	25	0	L	0.75
dexamethasone	25	0	L	0.75

「betamethasone 17-valerate」

　　[★]

17-吉草酸ベタメタゾン、吉草酸ベタメタゾン

関: betamethasone、betamethasone dipropionate、betamethasone sodium phosphate、betamethasone valerate

「吉草酸ベタメタゾン」

　　[★]

英: betamethasone valerate、betamethasone 17-valerate
関: ベタメタゾン吉草酸エステル、17-吉草酸ベタメタゾン

「BETA-VAL」

　　[★]

関: betamethasone valerate

「BETATREX」

　　[★]

関: betamethasone valerate

「valerate」

　　[★]

吉草酸、吉草酸エステル、吉草酸塩

関: valeric acid

valeric acid

[AHFS2015-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Betamethasone". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.

[AHFS2015Top-2] "Betamethasone topical". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.

[3] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[Ric2015-4] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 186,201. ISBN 9781284057560.

[A_Randomized_Trial_of_Oral_Betamethazone_to_Reduce_Ataxia_Symptoms_in_Ataxia_Telangiectasia-5] Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders : official journal of the Movement Disorder Society 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201.

[6] Moreno, G; Corbalán, J; Peñaloza, B; Pantoja, T (2 September 2014). "Topical corticosteroids for treating phimosis in boys.". The Cochrane database of systematic reviews 9: CD008973. PMID 25180668.

[vanHowe1998-7] Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.

[World_Journal_of_Urology-8] Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190

[Pediatric_Surgery_International-9] Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335

[Berdue2001-10] Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650.

[Chu1999-11] Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.

[12] ttp://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN

リンク元	「ベタメタゾン」「betamethasone 17-valerate」「吉草酸ベタメタゾン」「BETA-VAL」「BETATREX」
関連記事	「valerate」

匿名

検索

案内

案内

betamethasone valerate