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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/20 16:57:06」(JST)

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Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.

Forms

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, and others), sodium phosphate (branded as Bentelan in Italy^[1]) and valerate (branded as Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm.

Indications

Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision. ^[2]^[3]^[4] It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.^[5]^[6]

Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.

As it crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.^{[citation needed]}

References

^ http://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN
^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. http://pediatrics.aappublications.org/cgi/content/full/102/4/e43. A review of estimated costs and complications of 3 phimosis treatments.
^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1464-4096&date=2001&volume=87&issue=3&spage=239.
^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.

External links

"Betamethasone". safefetus.com. http://www.safefetus.com/DrugDetail.asp?DrugId=709&TradeName=Betaval&TradeId=775.

UpToDate Contents

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1. 早産による新生児の罹病および死亡を減少させるための出産前ステロイド療法 antenatal corticosteroid therapy for reduction of neonatal morbidity and mortality from preterm delivery
2. 早期分娩および早期産の概要 overview of preterm labor and birth
3. クループ：薬剤および補助治療 croup pharmacologic and supportive interventions
4. 包皮非切除者の陰茎のケア care of the uncircumcised penis
5. 全身性ステロイドに対する過敏反応 hypersensitivity reactions to systemic glucocorticoids

English Journal

Retrospective analysis on the efficacy of corticosteroid prophylaxis prior to elective caesarean section to reduce neonatal respiratory complications at term of pregnancy: review of literature.

Paganelli S, Soncini E, Gargano G, Capodanno F, Vezzani C, La Sala GB.SourceDepartment of Obstetrics and Gynecology, Arcispedale S. Maria Nuova, Istituto Tecnologie Avanzate e Modelli Assistenziali in Oncologia, IRCCS, Azienda Santa Maria Nuova, Viale Risorgimento, 80, 42123, Reggio Emilia, Italy, simone.paganelli@asmn.re.it.
Archives of gynecology and obstetrics.Arch Gynecol Obstet.2013 Dec;288(6):1223-9. doi: 10.1007/s00404-013-3035-1. Epub 2013 Sep 27.
PURPOSE: Our purpose was to conduct a systematic review of the literature to determine whether synthetic pharmaceutical glucocorticoids (betamethasone and dexamethasone) are safe as well as effective in reducing neonatal respiratory morbidity at term of pregnancy prior to elective caesarean section.
PMID 24071819

The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx.

Caswell M.SourceConsumer Product Testing Company Inc, Fairfield, New Jersey. Electronic address: mcaswell@cptclabs.com.
Journal of the American Academy of Dermatology.J Am Acad Dermatol.2013 Dec;69(6):1059. doi: 10.1016/j.jaad.2013.03.046.
PMID 24238170

Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema.

Yousefi M, Barikbin B, Kamalinejad M, Abolhasani E, Ebadi A, Younespour S, Manouchehrian M, Hejazi S.SourceSkin Research Center, Shahid Beheshti University of Medical Sciences, TehranDepartment of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, TehranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, TehranSchool of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2013 Dec;27(12):1498-504. doi: 10.1111/jdv.12033. Epub 2012 Dec 1.
Background Nigella sativa has been used in traditional medicine. Although it was investigated in different studies, its effect on hand eczema has not been studied yet. Objective To compare the effects of Nigella, Betamethasone and Eucerin on severity of hand eczema and patients' life quality.
PMID 23198836

Related Pictures

Steroid Injections Celestone Soluspan Injectable Suspension Co., Inc. Celestone Soluspan - 6mg/ml, 5ml Drugs reference index « Celestone » CELESTONE ELIXIR 120ML CELESTONE (BETAMETHAZONE) 0.5mg 50TAB CELESTONE Cronodose ampolla 1 ml -PIEL Y CELESTONE 2MG 10 COMP

★リンクテーブル★

リンク元

「ベタメタゾン」

Betamethasone
Systematic (IUPAC) name
	(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
Clinical data
Trade names	Celestone
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	℞ Prescription only
Routes	oral or topical
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic CYP3A4
Half-life	36-54 hours
Excretion	Renal (in urine)
Identifiers
CAS number	378-44-9
ATC code	A07EA04 C05AA05 D07AC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
PubChem	CID 9782
DrugBank	DB00443
ChemSpider	9399
UNII	9842X06Q6M
KEGG	D00244
ChEBI	CHEBI:3077
ChEMBL	CHEMBL632
Chemical data
Formula	C22H29FO5
Mol. mass	392.461
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C;
	InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 ; Key:UREBDLICKHMUKA-DVTGEIKXSA-N ;
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　　[★]

英: betamethasone
同: ベタメサゾン
化: ベタメタゾンリン酸エステルナトリウム、リン酸ベタメタゾンナトリウム betamethasone sodium phosphate; 酢酸ベタメタゾン betamethasone acetate; 吉草酸ベタメタゾン betamethasone valerate。ベタメタゾン吉草酸エステル; ベタメタゾンジプロピオン酸エステル、ジプロピオン酸ベタメタゾン betamethasone dipropionate; ベタメタゾン酪酸エステルプロピオン酸エステル
商: リンデロン Rinderon、アンテベート。Celestone; アンテベート、アンフラベート、エンペラシン、ケリグロール、サクコルチン、サレックス、サンベタゾン、ステロネマ、セレスタミン、ダイプロセル、ディーピーポロン、デキサンVG、デルモゾールＤＰ、デルモゾールＧ、デルモゾール、トクダーム、トチプロベタゾン、ノルコット、ハイコート、ヒスタブロック、ヒズボット、フロダーム、プラデスミン、ベクトミラン、ベタセレミン、ベトネベートＮ、ベトネベート、ベトノバールＧ、ベルベゾロンF、ベルベゾロン、リダスロン、リネステロン、リノロサール、リンデロン-DP、リンデロン-VG、リンデロン-V、リンデロン、リンベタPF、ルリクールVG、リンデロンA
関: 鎮痛，鎮痒，収歛，消炎剤

GOO.1594

Table 59–2 Relative Potencies and Equivalent Doses of Representative Corticosteroids
COMPOUND	ANTIINFLAMMATORY POTENCY	Na+-RETAINING POTENCY	DURATION OF ACTION	EQUIVALENT DOSE, MG
prednisone	4	0.8	I	5
prednisolone	4	0.8	I	5
betamethasone	25	0	L	0.75
dexamethasone	25	0	L	0.75

[1] ttp://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN

[vanHowe1998-2] Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. http://pediatrics.aappublications.org/cgi/content/full/102/4/e43. A review of estimated costs and complications of 3 phimosis treatments.

[World_Journal_of_Urology-3] Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190

[Pediatric_Surgery_International-4] Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335

[Berdue2001-5] Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1464-4096&date=2001&volume=87&issue=3&spage=239.

[Chu1999-6] Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.

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案内

Celestone