リン酸ベタメタゾンナトリウム

関: betamethasone、betamethasone 17-valerate、betamethasone acetate、betamethasone butyrate propionate、betamethasone dipropionate

WordNet

a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
carbonated drink with fruit syrup and a little phosphoric acid
a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

PrepTutorEJDIC

〈U〉リン酸塩 / 《複数形で》リン酸肥料
ソジウム,ナトリウム(金属元素;化学記号はNa)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/02 01:58:13」(JST)

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[Wiki en表示]

Betamethasone is a steroid medication.^[1] It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby's lungs, Crohn's disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others.^[1] It can be taken by mouth, injected into a muscle, or applied as a cream.^[1]^[2] When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.^[1]

Serious side effects include an increased risk of infection, muscle weakness, severe allergic reactions, and psychosis. Long-term use may cause adrenal insufficiency. Stopping the medication suddenly following long-term use may be dangerous.^[1] The cream commonly results in increased hair growth and skin irritation.^[2] Betamethasone belongs to the glucocorticoid class of medication.^[1]

Betamethasone was approved for medical use in the United States in 1961.^[1] The cream is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.^[3] It is available as a generic medication.^[1] In the United States the pills and injectable solution are expensive while the cream is not.^[4]

Medical uses

Betamethasone is a corticosteroid that is available as pill, by injection, and as a cream.

It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination calcipotriol/betamethasone dipropionate. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals include the steroid as the valerate ester.

In a randomized controlled trial betamethasone was shown to reduce some of the ataxia symptoms associated with ataxia telangiectasia (A-T) by 28-31%.^[5]

Betamethasone is also used to stimulate fetal lung maturation (to prevent IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys,^[6] and often averts the need for circumcision.^[7]^[8]^[9] It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.^[10]^[11]

Side effects

Skin irritation, e.g. itching, burning, stinging
Thinning of the skin
Changes in skin pigmentation and coloration
Stretch marks (striae)
Groupings of fine blood vessels becoming prominent under the skin (telangiectasia)
Excessive hair growth (hypertrichosis)

Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds, or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the adrenal glands.

Betamethasone is also used prior to delivery of a preterm baby to help prepare the lungs for breathing. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.^{[citation needed]}

When injected into the epidural space or the spine, it may cause serious side effects like loss of vision, stroke, and paralysis.^[12]

Forms

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort (in Pakistan), and others), betamethasone sodium phosphate (branded as Bentelan in Italy) and betamethasone valerate (branded as Audavate, Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid for using in psoriatic skin conditions. In Mexico it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix.

References

^ ^a ^b ^c ^d ^e ^f ^g ^h "Betamethasone". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.
^ ^a ^b "Betamethasone topical". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.
^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 186,201. ISBN 9781284057560.
^ Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders: official journal of the Movement Disorder Society. 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201.
^ Moreno, G; Corbalán, J; Peñaloza, B; Pantoja, T (2 September 2014). "Topical corticosteroids for treating phimosis in boys.". The Cochrane database of systematic reviews. 9: CD008973. doi:10.1002/14651858.CD008973.pub2. PMID 25180668.
^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics. 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.
^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650.
^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.
^ "FDA Drug Safety Communication: FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for pain". FDA. 23 April 2014. Retrieved 15 August 2016.

External links

"Betamethasone". safefetus.com.

UpToDate Contents

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1. 早産による新生児の罹病および死亡を減少させるための出産前ステロイド療法 antenatal corticosteroid therapy for reduction of neonatal morbidity and mortality from preterm delivery
2. クループ：薬剤および補助治療 croup pharmacologic and supportive interventions
3. 全身性ステロイドに対する過敏反応 hypersensitivity reactions to systemic glucocorticoids
4. 包皮非切除者の陰茎のケア care of the uncircumcised penis
5. 慢性的な手の湿疹 chronic hand eczema

English Journal

Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses.

Menendez MI1, Phelps MA, Bertone AL.
Journal of veterinary pharmacology and therapeutics.J Vet Pharmacol Ther.2015 Apr 3. doi: 10.1111/jvp.12229. [Epub ahead of print]
To the date, no reports exist of the pharmacokinetics (PK) of betamethasone (BTM) sodium phosphate and betamethasone acetate administered intra-articular (IA) into multiple joints in exercising horses. The purpose of the study was to determine the PK of BTM and HYD concentrations in plasma and urine
PMID 25847081

Differential cytotoxicity of corticosteroids on human mesenchymal stem cells.

Wyles CC1, Houdek MT, Wyles SP, Wagner ER, Behfar A, Sierra RJ.
Clinical orthopaedics and related research.Clin Orthop Relat Res.2015 Mar;473(3):1155-64. doi: 10.1007/s11999-014-3925-y. Epub 2014 Sep 4.
BACKGROUND: Corticosteroids are a common, short-term, local antiinflammatory and analgesic for treating patients with musculoskeletal disorders. Studies have shown the deleterious effects of corticosteroids on chondrocytes, suggesting a potentiation of degenerative joint disease. Mesenchymal stem ce
PMID 25187334

Cardiovascular risk factors in children after repeat doses of antenatal glucocorticoids: an RCT.

McKinlay CJ1, Cutfield WS1, Battin MR2, Dalziel SR3, Crowther CA4, Harding JE5; ACTORDS Study Group.
Pediatrics.Pediatrics.2015 Feb;135(2):e405-15. doi: 10.1542/peds.2014-2408. Epub 2015 Jan 19.
BACKGROUND: Treatment of women at risk for preterm birth with repeat doses of glucocorticoids reduces neonatal morbidity but could have adverse long-term effects on cardiometabolic health in offspring. We assessed whether exposure to repeat antenatal betamethasone increased risk factors for later ca
PMID 25601978

Japanese Journal

症例リン酸ベタメタゾン・硫酸フラジオマイシン配合剤による接触皮膚炎の1例

山村里恵,敷地孝法
皮膚科の臨床 53(8), 1137-1142, 2011-08
NAID 40018942662

Inhibitory Effects of Cyclosporine A Eye Drops on Symptoms in Late Phase and Delayed-Type Reactions in Allergic Conjunctivitis Models

Shii Daisuke,Nakagawa Shizu,Yoshimi Miwa,Katsuta Osamu,Oda Tomoko,Nakamura Masatsugu
Biological & Pharmaceutical Bulletin 33(8), 1314-1318, 2010
… In contrast, betamethasone sodium phosphate eye drops showed a tendency to inhibit the symptoms in both late phase and delayed-type reactions, or inflammatory cell infiltration in the late phase reaction, but the inhibition was not significant. …
NAID 130000300353

「ベタメタゾン」

Betamethasone
Clinical data
Trade names	Celestone
AHFS/Drugs.com	Monograph
Pregnancy; category	US: C (Risk not ruled out); ;
Routes of; administration	Oral,Topical,IM
ATC code	A07EA04 (WHO) C05AA05 (WHO) D07AC01 (WHO) H02AB01 (WHO) R01AD06 (WHO) R03BA04 (WHO) S01BA06 (WHO) S02BA07 (WHO) S03BA03 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic CYP3A4
Biological half-life	36-54 hours
Excretion	Renal (in urine)
Identifiers
	IUPAC name (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one;
CAS Number	378-44-9 ;
PubChem CID	9782;
IUPHAR/BPS	7061;
DrugBank	DB00443 ;
ChemSpider	9399 ;
UNII	9842X06Q6M;
KEGG	D00244 ;
ChEBI	CHEBI:3077 ;
ChEMBL	CHEMBL632 ;
ECHA InfoCard	100.006.206
Chemical and physical data
Formula	C22H29FO5
Molar mass	392.461
3D model (Jmol)	Interactive image;
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C ;
	InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 ; Key:UREBDLICKHMUKA-DVTGEIKXSA-N ;
(verify)

　　[★]

英: betamethasone
同: ベタメサゾン
化: ベタメタゾンリン酸エステルナトリウム、リン酸ベタメタゾンナトリウム betamethasone sodium phosphate; 酢酸ベタメタゾン betamethasone acetate; 吉草酸ベタメタゾン betamethasone valerate。ベタメタゾン吉草酸エステル; ベタメタゾンジプロピオン酸エステル、ジプロピオン酸ベタメタゾン betamethasone dipropionate; ベタメタゾン酪酸エステルプロピオン酸エステル
商: リンデロン Rinderon、アンテベート。Celestone; アンテベート、アンフラベート、エンペラシン、ケリグロール、サクコルチン、サレックス、サンベタゾン、ステロネマ、セレスタミン、ダイプロセル、ディーピーポロン、デキサンVG、デルモゾールＤＰ、デルモゾールＧ、デルモゾール、トクダーム、トチプロベタゾン、ノルコット、ハイコート、ヒスタブロック、ヒズボット、フロダーム、プラデスミン、ベクトミラン、ベタセレミン、ベトネベートＮ、ベトネベート、ベトノバールＧ、ベルベゾロンF、ベルベゾロン、リダスロン、リネステロン、リノロサール、リンデロン-DP、リンデロン-VG、リンデロン-V、リンデロン、リンベタPF、ルリクールVG、リンデロンA
関: 鎮痛，鎮痒，収歛，消炎剤

GOO.1594

Table 59–2 Relative Potencies and Equivalent Doses of Representative Corticosteroids
COMPOUND	ANTIINFLAMMATORY POTENCY	Na+-RETAINING POTENCY	DURATION OF ACTION	EQUIVALENT DOSE, MG
prednisone	4	0.8	I	5
prednisolone	4	0.8	I	5
betamethasone	25	0	L	0.75
dexamethasone	25	0	L	0.75

「betamethasone dipropionate」

　　[★]

ジプロピオン酸ベタメタゾン

関: betamethasone、betamethasone 17-valerate、betamethasone acetate、betamethasone butyrate propionate、betamethasone sodium phosphate

「betamethasone 17-valerate」

　　[★]

17-吉草酸ベタメタゾン、吉草酸ベタメタゾン

関: betamethasone、betamethasone dipropionate、betamethasone sodium phosphate、betamethasone valerate

「betamethasone butyrate propionate」

　　[★]

酪酸プロピオン酸ベタメタゾン

関: betamethasone、betamethasone acetate、betamethasone dipropionate、betamethasone sodium phosphate

「betamethasone acetate」

　　[★]

酢酸ベタメタゾン

関: betamethasone、betamethasone butyrate propionate、betamethasone dipropionate、betamethasone sodium phosphate

「phosphate」

　　[★]

n.

(化合物)リン酸塩、リン酸エステル、ホスフェート、フォスフェート、リン酸

関: inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus

[AHFS2015-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Betamethasone". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.

[AHFS2015Top-2] "Betamethasone topical". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.

[WHO19th-3] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[Ric2015-4] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 186,201. ISBN 9781284057560.

[A_Randomized_Trial_of_Oral_Betamethazone_to_Reduce_Ataxia_Symptoms_in_Ataxia_Telangiectasia-5] Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders: official journal of the Movement Disorder Society. 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201.

[6] Moreno, G; Corbalán, J; Peñaloza, B; Pantoja, T (2 September 2014). "Topical corticosteroids for treating phimosis in boys.". The Cochrane database of systematic reviews. 9: CD008973. doi:10.1002/14651858.CD008973.pub2. PMID 25180668.

[vanHowe1998-7] Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics. 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.

[World_Journal_of_Urology-8] Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190

[Pediatric_Surgery_International-9] Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335

[Berdue2001-10] Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650.

[Chu1999-11] Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.

[12] "FDA Drug Safety Communication: FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for pain". FDA. 23 April 2014. Retrieved 15 August 2016.

v t e Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)

Rehydration	Oral rehydration therapy

Intestinal anti-infectives	Antibiotics Amphotericin B Colistin Fidaxomicin Kanamycin Natamycin Neomycin Nystatin Paromomycin Polymyxin B Rifaximin Streptomycin Vancomycin Sulfonamides Phthalylsulfathiazole Succinylsulfathiazole Sulfaguanidine Nitrofuran Nifuroxazide Nifurzide Imidazole Miconazole Arsenical Acetarsol Oxyquinoline Broxyquinoline

Intestinal adsorbents	Charcoal Bismuth Pectin Kaolin Crospovidone Attapulgite Diosmectite

Antipropulsives (opioids)	Opium tincture (laudanum) Codeine Morphine Camphorated opium tincture (paregoric) crosses BBB: Diphenoxylate (Diphenoxylate/atropine) Difenoxin does not cross BBB: Eluxadoline Loperamide

Intestinal anti-inflammatory agents	corticosteroids acting locally Prednisolone Hydrocortisone Prednisone Betamethasone Tixocortol Budesonide Beclometasone antiallergic agents, excluding corticosteroids Cromoglicic acid aminosalicylic acid and similar agents Sulfasalazine Mesalazine Olsalazine Balsalazide

Antidiarrheal micro-organisms	Saccharomyces boulardii

Other antidiarrheals	Albumin tannate Ceratonia Crofelemer Octreotide Racecadotril

v t e Drugs used for diseases of the ear (S02)

Infection	Acetic acid Aluminium acetotartrate Aluminium triacetate (Burow's solution) Boric acid Chloramphenicol Chlorhexidine Ciprofloxacin Clioquinol Gentamicin Hydrogen peroxide Miconazole Neomycin Nitrofurazone Ofloxacin Polymyxin B Rifamycin Tetracycline

Corticosteroids	Betamethasone Dexamethasone Fluocinolone acetonide Hydrocortisone Prednisolone

Analgesics and anesthetics	Lidocaine Cocaine Phenazone

リンク元	「ベタメタゾン」「betamethasone dipropionate」「betamethasone 17-valerate」「betamethasone butyrate propionate」「betamethasone acetate」
関連記事	「phosphate」

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betamethasone sodium phosphate