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Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.^[1]

Medical uses

Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals, include the steroid as the valerate ester.

In a randomized controlled trial Betamethasone was shown to reduce some of the ataxia symptoms associated with Ataxia Telangiectasia (A-T) by 28-31%.^[2]

Alternative medical approach for large microcystic CCAMs – Betamethasone therapy^{[citation needed]}

Betamethasone is also used prior to delivery of a preterm baby to help prepare the lung for breathing.

Betamethasone is also used to treat phimosis (tight foreskin) in uncircumcised boys. ^[3]

Side effects

Skin irritation, e.g. itching, burning, stinging.
Thinning of the skin.
Changes in skin pigmentation and coloration.
Stretch marks (striae).
Groupings of fine blood vessels becoming prominent under the skin (telangiectasia).
Excessive hair growth (hypertrichosis).

Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the adrenal glands.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision.^[4]^[5]^[6] It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.^[7]^[8]

Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.^{[citation needed]}

Forms

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort in Pakistan and others), sodium phosphate (branded as Bentelan in Italy^[9]) and valerate (branded as Audavate, Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid for using in psoriatic skin conditions. In Mexico it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix.

References

^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
^ Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders : official journal of the Movement Disorder Society 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201.
^ http://www.ncbi.nlm.nih.gov/pubmed/8976781
^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.
^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650.
^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.
^ http://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN

External links

"Betamethasone". safefetus.com.

English Journal

[Causes of gelatinous material on ocular surface of a patient using timolol maleate long-acting eye drops].

Sukegawa T1.
Nippon Ganka Gakkai zasshi.Nihon Ganka Gakkai Zasshi.2012 Jun;116(6):554-9.
PURPOSE: To ascertain the causes of the formation of gelatinous material observed on the ocular surface of a patient using a betamethasone sodium phosphate ophthalmic solution containing fradiomycin sulfate (Rinderon-A) together with a timolol maleate long-acting ophthalmic gel-forming solution (Tim
PMID 22774594

Comparative assessment of the cytotoxicity of six anti-inflammatory eyedrops in four cultured ocular surface cell lines, as determined by cell viability scores.

Ayaki M1, Iwasawa A, Niwano Y.
Clinical ophthalmology (Auckland, N.Z.).Clin Ophthalmol.2012;6:1879-84. doi: 10.2147/OPTH.S36968. Epub 2012 Nov 13.
PURPOSE: Anti-inflammatory eyedrops are often used in the treatment of corneal epithelial disorders. In the present study, we evaluated the cytotoxicity of six anti-inflammatory eyedrops in four ocular surface cell lines.METHODS: The cytotoxicity of six commercially available anti-inflammatory ophth
PMID 23185116

Investigation of patients' satisfaction in using potent topical corticosteroid preparations.

Shibata Y1, Ikeda H, Kihira K.
Hiroshima journal of medical sciences.Hiroshima J Med Sci.2007 Dec;56(3-4):33-9.
The purpose of this study is to elucidate the physical properties of various commercially available topical corticosteroid preparations. We compared comfort after application and the physical properties affecting topical application among brands of commercially available topical corticosteroid ointm
PMID 18516932

Japanese Journal

ヒアルロン酸およびステロイドの腱板由来線維芽細胞への影響

白地功,永田見生,後藤昌史,光井康博,樋口富士男
肩関節 35(3), 825-827, 2011
… The tendon fibroblasts were cultured in the presence of HA (Artz<SUP>®</SUP>,1.0mg/ml) or various concentrations of steroid (Rinderon<SUP>®</SUP>, 2.5-10mg/ml) for 24 hrs. …
NAID 130002103633

篩骨洞原発神経内分泌小細胞癌例

小野倫嗣,横井秀格,小池泉,田崎京子,加瀬香,芳川洋,池田勝久
耳鼻咽喉科臨床 102(8), 645-650, 2009-08-01
… We performed treatment for convulsion with glyceol, rinderon and phenytoin. …
NAID 10025096952

Experimental Study on the Effect of the Steroid on Mucosal Damage by Ethanol Injection

TAGUCHI AIKO,WU MEN-DAR,SATO HIROAKI,NAKAYAMA MEIHO,KIMURA MASARU,INAFUKU SHIGERU
愛知医科大学医学会雑誌 35(2), 87-98, 2007-06
… After the 70% ethanol was applied to the submucosa of the left palatine arch and the E/S mixture containing betamethasone(Rinderon^[○!R]) with several different concentrations per group to the submucosa of the right palatine arch for the same guinea pigs, the change of the local mucosa was observed macroscopically and histopathologically with passage of time. …
NAID 110006966654

★リンクテーブル★

リンク元

「ベタメタゾン」

Betamethasone
Systematic (IUPAC) name
	(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
Clinical data
Trade names	Celestone
AHFS/Drugs.com	monograph
Pregnancy; category	US: C (Risk not ruled out); ;
Legal status	℞ (Prescription only);
Routes of; administration	Oral,Topical,IM
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic CYP3A4
Biological half-life	36-54 hours
Excretion	Renal (in urine)
Identifiers
CAS Number	378-44-9
ATC code	A07EA04 C05AA05 D07AC01 H02AB01 R01AD06 R03BA04 S01BA06 S02BA07 S03BA03
PubChem	CID: 9782
IUPHAR/BPS	7061
DrugBank	DB00443
ChemSpider	9399
UNII	9842X06Q6M
KEGG	D00244
ChEBI	CHEBI:3077
ChEMBL	CHEMBL632
Chemical data
Formula	C22H29FO5
Molecular mass	392.461
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C ;
	InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 ; Key:UREBDLICKHMUKA-DVTGEIKXSA-N ;
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　　[★]

英: betamethasone
同: ベタメサゾン
化: ベタメタゾンリン酸エステルナトリウム、リン酸ベタメタゾンナトリウム betamethasone sodium phosphate; 酢酸ベタメタゾン betamethasone acetate; 吉草酸ベタメタゾン betamethasone valerate。ベタメタゾン吉草酸エステル; ベタメタゾンジプロピオン酸エステル、ジプロピオン酸ベタメタゾン betamethasone dipropionate; ベタメタゾン酪酸エステルプロピオン酸エステル
商: リンデロン Rinderon、アンテベート。Celestone; アンテベート、アンフラベート、エンペラシン、ケリグロール、サクコルチン、サレックス、サンベタゾン、ステロネマ、セレスタミン、ダイプロセル、ディーピーポロン、デキサンVG、デルモゾールＤＰ、デルモゾールＧ、デルモゾール、トクダーム、トチプロベタゾン、ノルコット、ハイコート、ヒスタブロック、ヒズボット、フロダーム、プラデスミン、ベクトミラン、ベタセレミン、ベトネベートＮ、ベトネベート、ベトノバールＧ、ベルベゾロンF、ベルベゾロン、リダスロン、リネステロン、リノロサール、リンデロン-DP、リンデロン-VG、リンデロン-V、リンデロン、リンベタPF、ルリクールVG、リンデロンA
関: 鎮痛，鎮痒，収歛，消炎剤

GOO.1594

Table 59–2 Relative Potencies and Equivalent Doses of Representative Corticosteroids
COMPOUND	ANTIINFLAMMATORY POTENCY	Na+-RETAINING POTENCY	DURATION OF ACTION	EQUIVALENT DOSE, MG
prednisone	4	0.8	I	5
prednisolone	4	0.8	I	5
betamethasone	25	0	L	0.75
dexamethasone	25	0	L	0.75

[1] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[A_Randomized_Trial_of_Oral_Betamethazone_to_Reduce_Ataxia_Symptoms_in_Ataxia_Telangiectasia-2] Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders : official journal of the Movement Disorder Society 27 (10): 1312–6. doi:10.1002/mds.25126. PMID 22927201.

[3] ttp://www.ncbi.nlm.nih.gov/pubmed/8976781

[vanHowe1998-4] Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.

[World_Journal_of_Urology-5] Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190

[Pediatric_Surgery_International-6] Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335

[Berdue2001-7] Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650.

[Chu1999-8] Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.

[9] ttp://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN

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案内

案内

Rinderon