aldose reductase inhibitor



  1. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
  2. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
  3. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
  4. a substance that retards or stops an activity
  5. an enzyme that catalyses the biochemical reduction of some specified substance
  6. a monosaccharide sugar that contains the aldehyde group or is hemiacetal


  1. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
  2. 抑制する人(物) / 化学反応抑制剤

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/11/22 22:50:27」(JST)

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English Journal

  • LC-MS/MS method for the quantification of aldose reductase inhibitor - Epalrestat and application to pharmacokinetic study.
  • Nirogi R, Kandikere V, Ajjala DR, Bhyrapuneni G, Muddana NR.SourceBiopharmaceutical Research, Suven Life Sciences Ltd., Serene Chambers, Road - 5, Avenue - 7, Banjara Hills, Hyderabad 500034, India. Electronic address:
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Feb 23;74:227-34. doi: 10.1016/j.jpba.2012.10.020. Epub 2012 Oct 23.
  • A simple and rapid LC-MS/MS method was developed and validated for the quantification of epalrestat, an aldose reductase inhibitor for the treatment of diabetic neuropathy. Following protein precipitation epalrestat and IS were eluted with 10mM ammonium acetate and acetonitrile using a rapid gradien
  • PMID 23245255
  • X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity.
  • Ruiz FX, Cousido-Siah A, Mitschler A, Farrés J, Parés X, Podjarny A.SourceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries 67404 Illkirch CEDEX, France; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Barcelona, Spain.
  • Chemico-biological interactions.Chem Biol Interact.2013 Jan 4. pii: S0009-2797(12)00283-9. doi: 10.1016/j.cbi.2012.12.013. [Epub ahead of print]
  • Only one crystal structure is currently available for tumor marker AKR1B10, complexed with NADP(+) and tolrestat, which is an aldose reductase inhibitor (ARI) of the carboxylic acid type. Here, the X-ray structure of the complex of the V301L substituted AKR1B10 holoenzyme with fidarestat, an ARI of
  • PMID 23295227
  • Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells.
  • Lyon RC, Li D, McGarvie G, Ellis EM.SourceStrathclyde Institute of Pharmacy & Biomedical Sciences, 161 Cathedral Street, University of Strathclyde, Glasgow G4 0RE, Scotland, UK; School of Science, University of the West of Scotland, Hamilton Campus, Almada Street, Hamilton ML3 0JB, Scotland, UK.
  • Neurochemistry international.Neurochem Int.2013 Jan;62(1):113-21. doi: 10.1016/j.neuint.2012.10.007. Epub 2012 Oct 22.
  • Reactive aldehydes including methyl glyoxal, acrolein and 4-hydroxy-2-nonenal (4-HNE) have been implicated in the progression of neurodegenerative diseases. The reduction of aldehydes to alcohols by the aldo-keto reductase (AKR) family of enzymes may represent an important detoxication route within
  • PMID 23084985

Japanese Journal

  • 糖尿病性神経障害 (特集 糖尿病治療薬update : 適正な血糖管理を目指して) -- (糖尿病合併症に対する薬物療法)
  • 加藤 義郎,神谷 英紀,中村 二郎
  • 日本臨床 73(3), 495-500, 2015-03
  • NAID 40020367331
  • アルドースリダクターゼ(AR)阻害薬:(-)- ラニレスタットの光学活性中間体の新規・光学選択的合成プロセス及びそのHPLC 光学純度評価法の開発
  • 西 博行,生中 雅也,西村 良夫
  • 安田女子大学紀要 42, 337-345, 2014-02-28
  • NAID 110009758245
  • Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice
  • Morikawa Toshio,Ninomiya Kiyofumi,Imamura Mio [他]
  • Journal of natural medicines 68(3), 561-566, 2014
  • NAID 40020091192

Related Links

aldose reductase inhibitor aldose reductase inhibitor Any of a family of compounds (e.g., epalrestat, ponalrestat, sorbinil, tolrestat) that block aldose reductase, which catalyses the reduction of glucose to sorbitol; accumulation of ...
Obrosova IG, Van Huysen C, Fathallah L, et al. An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense. FASEB J 2002; 16:123. Ramana KV ...

Related Pictures

File:Aldose reductase 1us0.png - Wikipedia  in Human Aldose Reductase (hALR2 Structures of aldose reductase inhibitorsAldose reductase inhibitor. Causes Aldose reductase has a high Km for both Aldose reductase inhibitor. Causes




aldose reductase inhibitor, ARI
  • 糖尿病自体の治療ではなく、糖尿病合併症の治療薬である
  • 糖尿病性末梢神経障害の治療に用いられる。


  • 高血糖では、細胞内で以下の反応が盛んに起こっている。ソルビトールが末梢神経障害の原因とされる。アルドース還元酵素阻害薬は細胞内のソルビトールの蓄積を妨げ、症状を改善する。



  [★] アルドース還元酵素阻害薬 aldose reductase inhibitor



  • v.
  • 抑制する、阻害する、阻止する




  • n.




  • n.
dehydrogenaseoxidaseoxidoreductasereducing enzyme