同: CPAH

WordNet

permission to proceed; "the plane was given clearance to land"
the distance by which one thing clears another; the space between them
the 16th letter of the Roman alphabet (同)p

PrepTutorEJDIC

〈U〉〈C〉(…の)取り片付け,除去,掃除《+『of』+『名』》 / 〈U〉〈C〉(積荷の)通関手続き,(船の)出港免状 / (またclearance sale)〈C〉大棚ざらいの売出し / 〈U〉〈C〉(手形の)決済,(小切手の)現金化 / 〈U〉〈C〉(二つの物の間の)あき,余裕;(特に)道路面・川の面から橋げたまでの高さ / 〈U〉〈C〉秘密情報の使用許可;(秘密情報を扱う人の)信頼性調査;公安調査
personal assistant個人秘書 / public address [system]
parking
phosphorusの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/10 00:56:26」(JST)

wiki en

Parameter	Value
renal blood flow	RBF=1000 ml/min
hematocrit	HCT=40%
renal plasma flow	RPF=600 ml/min
filtration fraction	FF=20%
glomerular filtration rate	GFR=120 ml/min
urine flow rate	V=1 mL/min

Sodium	Inulin	Creatinine	PAH
S_Na=150 mEq/L	S_In=1 mg/mL	S_Cr=0.01 mg/ml	S_PAH=
U_Na=710 mEq/L	U_In=150 mg/mL	U_Cr=1.25 mg/mL	U_PAH=
C_Na=5 mL/min	C_In=150 ml/min	C_Cr=125 mL/min	C_PAH=420 ml/min
			ER=90%
			ERPF=540 ml/min

Para-aminohippurate (PAH) clearance is a method used in renal physiology to measure renal plasma flow, which is a measure of renal function.

The concentration of PAH is measured in one arterial blood sample (P_PAH) and one urine sample(U_PAH). The urine flow (V) is also measured. Renal perfusion flow is then calculated by:

What is calculated is the effective renal plasma flow (eRPF). However, since the renal extraction ratio of PAH almost equals 1, then eRPF almost equals RPF.

Precision

The renal extraction ratio of PAH in a normal individual is approximately 0.92,^[1] and thus not exactly 1.0. Thus, this method usually underestimates RPF by approximately 10%. This margin of error is generally acceptable considering the ease with which eRPF is measured.

References

^ Reubi FC (September 1953). "Glomerular filtration rate, renal blood flow and blood viscosity during and after diabetic coma" (PDF). Circulation Res. 1 (5): 410–3. PMID 13082682.

External links

Renal Clearance Techniques

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 成人における肺高血圧症の概要 overview of pulmonary hypertension in adults
2. 全身性硬化症（強皮症）における肺動脈性高血圧症：定義、分類、危険因子、スクリーニング、および予後 pulmonary arterial hypertension in systemic sclerosis scleroderma definition classification risk factors screening and prognosis
3. 慢性血栓塞栓性肺高血圧症：内科的治療 chronic thromboembolic pulmonary hypertension medical treatment
4. 小児および思春期における有酸素運動試験の概要 overview of aerobic exercise testing in children and adolescents
5. 肺移植後の生理的変化 physiologic changes following lung transplantation

English Journal

Oat1/3 restoration protects against renal damage after ischemic AKI.

Schneider R1, Meusel M2, Betz B2, Held C2, Möller-Ehrlich K3, Büttner-Herold M4, Wanner C2, Gekle M5, Sauvant C6.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2015 Feb 1;308(3):F198-208. doi: 10.1152/ajprenal.00160.2014. Epub 2014 Nov 12.
Expression of proximal tubular organic anion transporters Oat1 and Oat3 is reduced by PGE2 after renal ischemia and reperfusion (I/R) injury. We hypothesized that impaired expression of Oat1/3 is decisively involved in the deterioration of renal function after I/R injury. Therefore, we administered
PMID 25391897

A prospective population pharmacokinetic analysis of sapropterin dihydrochloride in infants and young children with phenylketonuria.

Qi Y1, Mould DR, Zhou H, Merilainen M, Musson DG.
Clinical pharmacokinetics.Clin Pharmacokinet.2015 Feb;54(2):195-207. doi: 10.1007/s40262-014-0196-4.
BACKGROUND AND OBJECTIVES: Untreated phenylketonuria (PKU), a hereditary metabolic disorder caused by a genetic mutation in phenylalanine hydroxylase (PAH), is characterized by elevated blood phenylalanine (Phe) and severe neurologic disease. Sapropterin dihydrochloride, a synthetic preparation of n
PMID 25338975

Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.

Ishihara T1, Hayashi E1, Yamamoto S2, Kobayashi C2, Tamura Y3, Sawazaki R1, Tamura F1, Tahara K1, Kasahara T1, Ishihara T4, Takenaga M5, Fukuda K3, Mizushima T6.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2015 Jan 10;197:97-104. doi: 10.1016/j.jconrel.2014.10.029. Epub 2014 Nov 6.
Prostaglandin I2 (PGI2) and its analogues (such as beraprost sodium, BPS) are beneficial for the treatment of pulmonary arterial hypertension (PAH). The encapsulation of BPS in nanoparticles to provide sustained release and targeting abilities would improve both the therapeutic effect of BPS on PAH
PMID 25449809

Japanese Journal

Measurement of renal blood flow in human subjects using the ultrasound velocity profiling technique

TAKANO Ryuichi,TANIGUCHI Nobuyuki,ITOH Kouichi,KUSANO Eiji
Journal of medical ultrasonics : official journal of the Japan Society of Ultrasonics in Medicine 33(2), 91-97, 2006-06-15
NAID 10017614822

速度 profile 法を用いた腎血流測定値の精度する検討 : PAHクリアランス法との比較

高野隆一,谷口信行,伊東紘一
Journal of medical ultrasonics = 超音波医学 28(3), 601, 2001-04-15
NAID 10012356471

Related Pictures

PPT - Renal clearance PowerPoint Presentation - ID:2090654 PPT - PLASMA CLEARANCE AND RENAL BLOOD FLOW PowerPoint Presentation, free download Para-Aminohippurate (PAH) Clearance and Renal Plasma Flow (RPF)

★リンクテーブル★

リンク元	「パラアミノ馬尿酸クリアランス」
関連記事	「PAH」「PA」「P」「clearance」

「パラアミノ馬尿酸クリアランス」

　　[★]

英: p-aminohippuric acid clearance CPAH
同: PAHクリアランス PAH clearance。パラアミノ馬尿酸ナトリウムクリアランス sodium paraaminohippurate clearance
関: パラアミノ馬尿酸、腎血漿流量 RPF

[show details]

パラアミノ馬尿酸ナトリウムクリアランス : 7 件
パラアミノ馬尿酸クリアランス : 94 件

「PAH」

　　[★]

p-aminohippurate sodium パラアミノ馬尿酸ナトリウム

パラアミノ馬尿酸 para-aminohippuric acid

「PA」

　　[★]

微生物学：粒子凝集法(particle agglutination test)
薬理学：

「P」

　　[★]

「clearance」

　　[★] クリアランス　　　

[1] Reubi FC (September 1953). "Glomerular filtration rate, renal blood flow and blood viscosity during and after diabetic coma" (PDF). Circulation Res. 1 (5): 410–3. PMID 13082682.

匿名

検索

案内

案内

PAH clearance