GABA transporter 1

GABA輸送体1、GABAトランスポーター1

関

GABA plasma membrane transport protein、GABA transporter、GABA transporter 2、GAT1

WordNet

1. move something or somebody around; usually over long distances
2. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
3. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
4. transport commercially (同)send, ship
5. a long truck for carrying motor vehicles (同)car transporter
6. a crane for moving material with dispatch as in loading and unloading ships

PrepTutorEJDIC

1. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
2. 自動車運搬用大型トラック
3. General Admiral / (またGa)Georgia

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/20 13:31:28」(JST)

wiki en

[Wiki en表示]

Solute carrier family 6 (neurotransmitter transporter), member 1
Identifiers
Symbols	SLC6A1 ; GABATHG; GABATR; GAT1
External IDs	OMIM: 137165 MGI: 95627 HomoloGene: 2290 IUPHAR: 929 ChEMBL: 1903 GeneCards: SLC6A1 Gene
Gene ontology Molecular function • neurotransmitter:sodium symporter activity • gamma-aminobutyric acid:sodium symporter activity Cellular component • plasma membrane • integral component of plasma membrane • cell surface • membrane • integral component of membrane • axon Biological process • transport • synaptic transmission • neurotransmitter secretion • learning • response to toxic substance • response to sucrose • response to lead ion • positive regulation of gamma-aminobutyric acid secretion • response to purine-containing compound • negative regulation of synaptic transmission, GABAergic • response to estradiol • response to cocaine • protein homooligomerization • response to calcium ion • gamma-aminobutyric acid import • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6529	232333
Ensembl	ENSG00000157103	ENSMUSG00000030310
UniProt	P30531	P31648
RefSeq (mRNA)	NM_003042	NM_178703
RefSeq (protein)	NP_003033	NP_848818
Location (UCSC)	Chr 3: 11.03 – 11.08 Mb	Chr 6: 114.28 – 114.32 Mb
PubMed search	[1]	[2]

GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.

Function

GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.

Interactions

SLC6A1 has been shown to interact with STX1A.

See also

• Solute carrier family
• GABA transporter 2
• GABA transporter 3

References

Further reading

• Nelson H, Mandiyan S, Nelson N (1990). "Cloning of the human brain GABA transporter.". FEBS Lett. 269 (1): 181–4. doi:10.1016/0014-5793(90)81149-I. PMID 2387399. 
• Bennett ER, Kanner BI (1997). "The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.". J. Biol. Chem. 272 (2): 1203–10. doi:10.1074/jbc.272.2.1203. PMID 8995422. 
• Bismuth Y, Kavanaugh MP, Kanner BI (1997). "Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.". J. Biol. Chem. 272 (26): 16096–102. doi:10.1074/jbc.272.26.16096. PMID 9195904. 
• DeFelipe J, González-Albo MC (1998). "Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.". NeuroReport 9 (3): 467–70. doi:10.1097/00001756-199802160-00020. PMID 9512391. 
• Conti F, Melone M, De Biasi S, Minelli A, Brecha NC, Ducati A (1998). "Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.". J. Comp. Neurol. 396 (1): 51–63. doi:10.1002/(SICI)1096-9861(19980622)396:1<51::AID-CNE5>3.0.CO;2-H. PMID 9623887. 
• Beckman ML, Bernstein EM, Quick MW (1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.". J. Neurosci. 18 (16): 6103–12. PMID 9698305. 
• Augood SJ, Waldvogel HJ, Münkle MC, Faull RL, Emson PC (1999). "Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.". Neuroscience 88 (2): 521–34. doi:10.1016/S0306-4522(98)00226-7. PMID 10197772. 
• Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). "A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.". J. Neurocytol. 27 (10): 719–30. doi:10.1023/A:1006946717065. PMID 10640187. 
• Deken SL, Beckman ML, Boos L, Quick MW (2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.". Nat. Neurosci. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172. 
• Whitworth TL, Quick MW (2001). "Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.". J. Biol. Chem. 276 (46): 42932–7. doi:10.1074/jbc.M107638200. PMID 11555659. 
• Hachiya Y, Takashima S (2002). "Development of GABAergic neurons and their transporter in human temporal cortex.". Pediatr. Neurol. 25 (5): 390–6. doi:10.1016/S0887-8994(01)00348-4. PMID 11744314. 
• Quick MW (2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91. doi:10.1073/pnas.082712899. PMC 122832. PMID 11960023. 
• Kanner BI (2003). "Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.". J. Biol. Chem. 278 (6): 3705–12. doi:10.1074/jbc.M210525200. PMID 12446715. 
• Zomot E, Kanner BI (2003). "The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.". J. Biol. Chem. 278 (44): 42950–8. doi:10.1074/jbc.M209307200. PMID 12925537. 
• Zhou Y, Bennett ER, Kanner BI (2004). "The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.". J. Biol. Chem. 279 (14): 13800–8. doi:10.1074/jbc.M311579200. PMID 14744863. 
• Hu JH, Ma YH, Jiang J, Yang N, Duan SH, Jiang ZH, Mei ZT, Fei J, Guo LH (2004). "Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).". NeuroReport 15 (1): 9–12. doi:10.1097/00001756-200401190-00003. PMID 15106822. 
• Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). "Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.". J. Biol. Chem. 279 (53): 55728–36. doi:10.1074/jbc.M409449200. PMID 15496410. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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English Journal

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• Xu H1, Wang Y, He Z, Yang H, Gao WQ.
• Cell cycle (Georgetown, Tex.).Cell Cycle.2015 Aug 3;14(15):2451-60. doi: 10.1080/15384101.2015.1060382.
• Degeneration or loss of GABAergic neurons frequently may lead to many neuropsychiatric disorders such as epilepsy and autism spectrum disorders. So far no clinically effective therapies can slow and halt the progression of these diseases. Cell-replacement therapy is a promising strategy for treatmen
• PMID 26114472

• Evidence for a Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters.

• Willford SL1, Anderson CM, Spencer SR, Eskandari S.
• The Journal of membrane biology.J Membr Biol.2015 Aug;248(4):795-810. doi: 10.1007/s00232-015-9797-6. Epub 2015 Apr 1.
• Plasma membrane γ-aminobutyric acid (GABA) transporters (GATs) are electrogenic transport proteins that couple the cotranslocation of Na(+), Cl(-), and GABA across the plasma membrane of neurons and glia. A fundamental property of the transporter that determines its ability to concentrate GABA in c
• PMID 25824654

• Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

• Adkins DE1, Clark SL1, Copeland WE2, Kennedy M3, Conway K4, Angold A2, Maes H5, Liu Y6, Kumar G1, Erkanli A2, Patkar AA2, Silberg J5, Brown TH7, Fergusson DM8, Horwood LJ8, Eaves L5, van den Oord EJ1, Sullivan PF9, Costello EJ2.
• Twin research and human genetics : the official journal of the International Society for Twin Studies.Twin Res Hum Genet.2015 Aug;18(4):335-47. doi: 10.1017/thg.2015.36. Epub 2015 Jun 17.
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• PMID 26081443

Japanese Journal

• Amino Acid Residues Involved in the Substrate Specificity of TauT/SLC6A6 for Taurine and γ-Aminobutyric Acid

• Yahara Tohru,Tachikawa Masanori,Akanuma Shin-ichi [他]
• Biological & pharmaceutical bulletin 37(5), 817-825, 2014-05
• NAID 40020048870

• 多様化形質細胞間の神経アミノ酸シグナルの普遍性

• 米田 幸雄
• YAKUGAKU ZASSHI 134(8), 879-887, 2014
• …   Both glutamic (Glu) and gamma-aminobutyric (GABA) acids are believed to play roles as neurotransmitters released from particular neurons into synaptic clefts in the mammalian central nervous system. … Although GABA has been shown to act as an extracellular signal outside the brain, little attention has been paid to the possible expression of machineries required for neuronal glutamatergic signaling in cells other than central neurons. …
• NAID 130004677652

• Antiallodynic Action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a Betaine/GABA Transporter Inhibitor

• Jinzenji Ayako,Sogawa Chiharu,Miyawaki Takuya [他],Wen Xue-fang,Yi Dan,Ohyama Kazumi,Kitayama Shigeo,Sogawa Norio,Morita Katsuya
• Journal of Pharmacological Sciences 125(2), 217-226, 2014
• … GABA transporters (GATs) play a role in controlling the synaptic clearance of GABA; … In the present study, we compared the betaine/GABA transporter (BGT-1) with other GAT subtypes to determine its participation in neuropathic pain using a mouse model of sciatic nerve ligation. …
• NAID 130004438625

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1. J Neurophysiol. 2003 Oct;90(4):2690-701. Epub 2003 Jun 18. GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. Jensen K, Chiu CS ...

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★リンクテーブル★

リンク元	「GABA plasma membrane transport protein」「GABA transporter 2」「GABAトランスポーター1」「GABA輸送体1」「GAT1」
関連記事	「GABA」「transport」「transporter」「GA」「GAB」

「GABA plasma membrane transport protein」

　　[★]

• 細胞膜GABAトランスポーター、細胞膜GABA輸送体、GABAトランスポーター、GABA輸送体

関

GABA transporter、GABA transporter 1、GABA transporter 2

「GABA transporter 2」

　　[★]

• GABA輸送体2、GABAトランスポーター2

関

GABA plasma membrane transport protein、GABA transporter、GABA transporter 1、GAT2

「GABAトランスポーター1」

　　[★]

英

GABA transporter 1

関

細胞膜GABAトランスポーター、GABA輸送体、GABA輸送体1、GABA輸送体2

「GABA輸送体1」

　　[★]

英

GABA transporter 1、GAT1

関

GABAトランスポーター1

「GAT1」

　　[★]

• GABA輸送体1

関

GABA transporter 1

「GABA」

　　[★]

butyl

英

γ-aminobutyric acid, γ-aminobutyrate, gamma aminobutyric acid

同

γ-アミノ酪酸、4-アミノ酪酸、γ-アミノ酪酸、γアミノ酪酸、ガンマアミノブチル酸

関

GABA受容体。ブチル

• アミノ酸からなる
• 抑制性神経伝達物質

構造

• 4炭素の炭化水素 butaneのカルボン酸 butyric acidをベースとして、γ位(カルボン酸の炭素につながっている炭素がα位)にアミノ基がついた構造

生合成

• グルタミン酸にグルタミン脱炭酸酵素が作用しγ-アミノ酪酸が生成する(補酵素：PLP) (SPC.77)

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein

　 　 　

「GA」

　　[★]

• グリコアルブミン glycosylated albumin

　

「GAB」

　　[★]

• γ-hydroxybutyic acid = GABA