Effects of chronic inhibition of GABA synthesis on attention and impulse control.
Paine TA1, Cooke EK2, Lowes DC2.
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2015 Jun 1;135:97-104. doi: 10.1016/j.pbb.2015.05.019. [Epub ahead of print]
BACKGROUND: Cortical GABA regulates a number of cognitive functions including attention and working memory and is dysregulated in a number of psychiatric conditions. In schizophrenia for example, changes in GABA neurons [reduced expression of glutamic acid decarboxylase (GAD), parvalbumin (PV) and t
American journal of human genetics.Am J Hum Genet.2015 May 7;96(5):808-15. doi: 10.1016/j.ajhg.2015.02.016. Epub 2015 Apr 9.
GAT-1, encoded by SLC6A1, is one of the major gamma-aminobutyric acid (GABA) transporters in the brain and is responsible for re-uptake of GABA from the synapse. In this study, targeted resequencing of 644 individuals with epileptic encephalopathies led to the identification of six SLC6A1 mutations
The Journal of dairy research.J Dairy Res.2015 May;82(2):228-35. doi: 10.1017/S0022029915000072. Epub 2015 Feb 23.
Glucose utilisation for lactose synthesis in the mammary gland involves expression of a large number of genes whose nutritional regulation remains poorly defined. In this study, the effect of long term under- and over-feeding on the expression of genes [glucose transporter 1: GLUT1, glucose transpor
Acronym Definition GAT1 Gamma-Aminobutyric Acid Transporter 1 GAT1 Glutaric Acidemia Type 1 (inherited metabolic disorder) ... Eight of the nine samples collected in the area in 2003 had the GAT1 haplotype, which was first ...
Protein, molecular pathway, molecule, protein kinase ... GAT1 requires an Na + gradient, because Na + influx provides the driving force. Hence, the activity of GAT1 is dependent on the membrane potential. Inward transport is ...