WordNet
- a drug combination found in some over-the-counter headache remedies (aspirin and phenacetin and caffeine)
PrepTutorEJDIC
- アスピリン(Aspirin)・フェナセチン(Phenacetin)・カフェイン(Caffeine)混合の鎮痛解熱剤
- antipersonnel / (またA.P.)Associated Press
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/28 07:23:47」(JST)
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- 1. 上室性期外収縮 supraventricular premature beats
- 2. 小児における不規則な心拍（不整脈） irregular heart rate arrhythmias in children
- 3. 心電図チュートリアル：心房性および房室結節性（上室性）不整脈 ecg tutorial atrial and atrioventricular nodal supraventricular arrhythmias
- 4. 妊娠中の上室性不整脈 supraventricular arrhythmias during pregnancy
- 5. プライマリケア医のための不整脈のマネージメント arrhythmia management for the primary care clinician
English Journal
- Is cancer vaccination feasible at older age?
- Gravekamp C1, Jahangir A2.Author information 1Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, United States. Electronic address: claudia.gravekamp@einstein.yu.edu.2Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, United States.AbstractAge-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor microenvironment (TME). This raises the question whether cancer vaccination is feasible at older age. We compared various cancer vaccine studies at young and old age, thereby focusing on the importance of both innate and adaptive immune responses for cancer immunotherapy. These analyses suggest that creating an immune-stimulating environment with help of the innate immune system may improve T cell responses in cancer vaccination at older age.
- Experimental gerontology.Exp Gerontol.2014 Jun;54C:138-144. doi: 10.1016/j.exger.2014.01.025. Epub 2014 Feb 6.
- Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor micr
- PMID 24509231
- Maternal schistosomiasis alters costimulatory molecules expression in antigen-presenting cells from adult offspring mice.
- Santos Pd1, Lorena VM2, Fernandes E1, Sales IR1, Albuquerque MC3, Gomes Y2, Costa VM3, Souza VM4.Author information 1Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, PE, Brazil.2Aggeu Magalhães Research Center (CPqAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife, PE, Brazil.3Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, PE, Brazil; Department of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife, PE, Brazil.4Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, PE, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: valdenia.souza@ufpe.br.AbstractAdult offspring of Schistosoma mansoni-infected mice showed alterations in immunity to a heterologous antigen, ovalbumin (OA). Prior breastfeeding induced increased production of anti-OA antibodies, while pregnancy impaired it. Here, we investigated the expression of costimulatory molecules on antigen-presenting cells (APCs) of the adult offspring of S. mansoni-infected mothers in response to OA. Newborn mice were divided into three groups: animals Born Infected Mothers (BIM) suckled by non-infected mothers; animals from non-infected mothers Suckled Infected Mothers (SIM); and another group of mice born from and suckled by non-infected mothers (CONTROL). The adult offspring were immunized with subcutaneous OA+adjuvant, and 3-8days following immunization, double labeling was performed (CD45R/B220 or CD11c and CD80, CD86, CD40 or HLA-DR) on spleen cells. In comparison to the CONTROL group, an early increased frequency of CD40+/CD80+ B cells was observed in SIM mice (p<0.001/p<0.05), but no alteration of CD11c+ cells was observed. In contrast, in BIM mice, the frequency of CD86+/CD11c+ cells (p<0.05) and CD40+/CD80+/CD86+ B cells (p<0.01/p<0.01/p<0.05) was drastically reduced. In conclusion, previous suckling by S. mansoni-infected mothers enabled improved antigen presentation by B cells in adult offspring, whereas gestation in these mothers imprinted offspring with weak antigen presentation by APCs during the immune response to a non-related antigen.
- Experimental parasitology.Exp Parasitol.2014 Jun;141:62-7. doi: 10.1016/j.exppara.2014.03.017. Epub 2014 Mar 21.
- Adult offspring of Schistosoma mansoni-infected mice showed alterations in immunity to a heterologous antigen, ovalbumin (OA). Prior breastfeeding induced increased production of anti-OA antibodies, while pregnancy impaired it. Here, we investigated the expression of costimulatory molecules on antig
- PMID 24657585
- Heat treatment improves antigen-specific T cell activation after protein delivery by several but not all yeast genera.
- Bazan SB1, Breinig T2, Schmitt MJ1, Breinig F3.Author information 1Molecular and Cell Biology, Saarland University, 66123 Saarbrücken, Germany.2Junior Research Group for Virology/Immunology, Department of Virology, Saarland University Hospital, 66421 Homburg, Germany.3Molecular and Cell Biology, Saarland University, 66123 Saarbrücken, Germany. Electronic address: fb@microbiol.uni-sb.de.AbstractA central prerequisite in using yeast as antigen carrier in vaccination is its efficient interaction with cellular components of the innate immune system, mainly mediated by cell surface structures. Here, we investigated the distribution of major yeast cell wall components such as mannan, β-glucan and chitin of four different and likewise biotechnologically relevant yeasts (Saccharomyces, Pichia, Kluyveromyces and Schizosaccharomyces) and analyzed the influence of heat-treatment on β-1,3-glucan exposure at the outer yeast cell surface as well as the amount of yeast induced reactive oxygen species (ROS) production by antigen presenting cells (APC) in human blood. We found that yeasts significantly differ in the distribution of their cell wall components and that heat-treatment affected both, cell wall composition and yeast-induced ROS production by human APCs. We further show that heat-treatment modulates the activation of antigen specific memory T cells after yeast-mediated protein delivery in different ways and thus provide additional support of using yeast as vehicle for the development of novel T cell vaccines.
- Vaccine.Vaccine.2014 May 7;32(22):2591-8. doi: 10.1016/j.vaccine.2014.03.043. Epub 2014 Mar 24.
- A central prerequisite in using yeast as antigen carrier in vaccination is its efficient interaction with cellular components of the innate immune system, mainly mediated by cell surface structures. Here, we investigated the distribution of major yeast cell wall components such as mannan, β-glucan
- PMID 24674665
Japanese Journal
- Immunoinflammatory Regulation Effects of Korean Hot Spring Water
- , , , , ,
- 日本温泉気候物理医学会雑誌 78(3), 253-270, 2015
- … These results showed that TLR-triggered inflammatory responses in APCs might also be modulated under HS water treatment. …
- NAID 130005072041
- β-1,3-グルカンを用いた薬物送達システムへの応用
- , , , ,
- Trends in Glycoscience and Glycotechnology 27(153), 13-29, 2015
- β-1,3-D-グルカンの一種であるシゾフィラン（SPG）はホモ配列のオリゴデオキシヌクレオチド（ODN）と水素結合や疎水性相互作用によってODN/SPG複合体を形成する。また、マクロファージや樹状細胞などの抗原提示細胞上には、β-1,3-D-グルカンの受容体であるデクチン-1が発現している。そのため、この複合体を用いることで、アンチセンスODN（AS-ODN）や非メチル化CpG配列を持ったODN …
- NAID 130004841395
- Electrospray Ionization Mass Spectrometry for the Quantification of Inorganic Cations and Anions
- ,
- Analytical Sciences 31(1), 7-14, 2015
- … Among the APCs studied, we found trans-1,2-diaminocyclohexane-N,N,N′,N′-tetraacetic acid (CyDTA, the chemical forms in a complex were expressed as Hncydtan−4) as the best chelating agent. …
- NAID 130004827449
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★リンクテーブル★
| リンク元 | 「抗原提示細胞」「alkylphosphocholines」「antigen-presenting cells」 |
| 関連記事 | 「APC」「AP」 |
「抗原提示細胞」
特徴
- MHC class IIを持ち、Th細胞に抗原提示を行うことができる
抗原提示細胞
「alkylphosphocholines」
「antigen-presenting cells」
「APC」
- 活性化タンパク質C activated protein C
- 抗原提示細胞 antigen presenting cell
- 心房性期外収縮 atrial premature contraction atrial premature complex
- 大腸ポリポーシス adenomatous polyposis coli
- 後期促進複合体 anaphase-promoting complex
- アルゴンプラズマ焼灼 アルゴンプラズマ凝固 argon plasma coaglation
「AP」
- 狭心症 angina pectoris,
- アルカリホスファターゼ alkaline phosphatase
- 活動電位 action potential
- アクチベーター蛋白質 activator protein
- アミノプリン aminopurine
- 順行性腎盂造影 antegrade pyelography