activator protein

• 活性化タンパク質、アクチベータータンパク質

• GM2 activator protein、activator protein-1

WordNet

1. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
2. (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription

PrepTutorEJDIC

1. antipersonnel / (またA.P.)Associated Press
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/24 07:56:12」(JST)

wiki en

[Wiki en表示]

A transcriptional activator is a protein that increases gene transcription of a gene or set of genes. Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements.

Most activators function by binding sequence-specifically to a DNA site located in or near a promoter and making protein-protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter. The DNA site bound by the activator is referred to as an "activator site." The part of the activator that makes protein-protein interactions with the general transcription machinery is referred to as an "activating region." The part of the general transcription machinery that makes protein-protein interactions with the activator is referred to as an "activation target."

Example

The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli. Cyclic adenosine monophosphate (cAMP) is produced during glucose starvation, binds to CAP, causes a conformational change that allows CAP to bind to a DNA site located adjacent to the lac promoter. CAP then makes a direct protein-protein interaction with RNA polymerase that recruits RNA polymerase to the lac promoter.

lac operon in detail

See also

• Glossary of gene expression terms
• Operon
• Promoter (biology)
• Regulation of gene expression
• Repressor
• Transcription factor

References

UpToDate Contents

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• 1. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
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• 5. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis

English Journal

• Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3-FOXO1 pathway.

• Miao H1, Ou J1, Zhang X1, Chen Y1, Xue B2, Shi H2, Gan L3, Yu L4, Liang H1.
• Clinical science (London, England : 1979).Clin Sci (Lond).2015 Apr 1;128(8):493-506. doi: 10.1042/CS20140414.
• Over-nutrition induces low-grade inflammation that dampens insulin sensitivity, but the underlying molecular mediators are not fully understood. Comparative gene identification-58 (CGI-58) is an intracellular lipolytic activator. In the present study, we show that in mouse visceral fat-derived macro
• PMID 25431838

• Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPKα-mediated reduction of DNA methyltransferase 1.

• Yie Y1, Zhao S, Tang Q, Zheng F, Wu J, Yang L, Deng S, Hann SS.
• Molecular and cellular biochemistry.Mol Cell Biochem.2015 Apr;402(1-2):63-74. doi: 10.1007/s11010-014-2314-x. Epub 2014 Dec 30.
• Hepatocellular carcinoma (HCC), the major histological subtype of primary liver cancer, remains one of the most common malignancies worldwide. Due to the complicated pathogenesis of this malignancy, the outcome for comprehensive treatment is limited. Chinese herbal medicine (CHM) is emerging as a
• PMID 25547067

• Astragalus and Paeoniae Radix Rubra extract (APE) inhibits hepatic stellate cell activation by modulating transforming growth factor-β/smad pathway.

• Huang W1, Li L1, Tian X2, Yan J3, Yang X3, Wang X1, Liao G1, Qiu G4.
• Molecular medicine reports.Mol Med Rep.2015 Apr;11(4):2569-77. doi: 10.3892/mmr.2014.3026. Epub 2014 Dec 1.
• Previous studies have shown that Astragalus and Paeoniae Radix Rubra extract (APE) is capable of protecting against liver fibrosis in rats. The hypothesis of the present study was that APE exerts its anti‑fibrotic effect by mediating the transforming growth factor β (TGF‑β)/Smad signaling pat
• PMID 25435153

Japanese Journal

• HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines.

• Sugata Kenji,Satou Yorifumi,Yasunaga Jun-Ichirou,Hara Hideki,Ohshima Kouichi,Utsunomiya Atae,Mitsuyama Masao,Matsuoka Masao
• Blood 119(2), 434-444, 2012-01-12
• … HBZ suppressed transcription from the IFN-γ gene promoter in a CD4 T cell-intrinsic manner by inhibiting nuclear factor of activated T cells and the activator protein 1 signaling pathway. …
• NAID 120003752111

• CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system

• Kanda Genki,Ochiai Hiroshi,Harashima Hideyoshi,Kamiya Hiroyuki
• Journal of Biotechnology 157(1), 7-11, 2012-01
• … The positive feedback system using a fusion protein of the sequence-specific DNA binding domain of yeast GAL4 and the transcription activation domain of herpes simplex virus VP16 (GAL4-VP16), in which GAL4-VP16 promotes its own expression as well as that of a reporter gene product, is useful for efficient transgene expression from plasmid DNA. …
• NAID 120003811532

Related Links

• Activator Protein - TV Serra Dourada - SBT

ACTIVATOR PROTEIN Saposin a second cerebrosidase activator c receptor protein hap. Contacts made between c receptor protein hap. Itself on the c receptor protein, srcap was cloned. Tfiid association with c receptor. Encode ...

• Activator protein 1 Antibodies - Antibody Resource Page

Activator protein 1 antibody comparison selector. A list of Activator protein 1 antibodies and Activator protein 1 antibody suppliers to help you quickly choose the most appropriate Activator protein 1 antibodies for your research. ... ...

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★リンクテーブル★

リンク元	「AP」「活性化タンパク質」「アクチベーター蛋白質」「アクチベータータンパク質」
拡張検索	「activator protein-1」「coactivator protein」「catabolite activator protein」「sphingolipid activator protein」
関連記事	「activator」

「AP」

　　[★]

• 狭心症 angina pectoris,
• アルカリホスファターゼ alkaline phosphatase
• 活動電位 action potential
• アクチベーター蛋白質 activator protein
• アミノプリン aminopurine
• 順行性腎盂造影 antegrade pyelography

　

「活性化タンパク質」

　　[★]

英

activator protein

関

アクチベータータンパク質

「アクチベーター蛋白質」

　　[★]

英

activator protein AP

同

活性化蛋白質

「アクチベータータンパク質」

　　[★]

英

activator protein

関

活性化タンパク質

「activator protein-1」

　　[★]

アクチベータータンパク質1

関

AP-1、transcription factor AP-1

「coactivator protein」

　　[★]

• コアクチベータータンパク質、共活性化タンパク質

「catabolite activator protein」

　　[★] カタボライト・アクチベータ・プロテイン

「sphingolipid activator protein」

　　[★]

• スフィンゴ脂質活性化タンパク質

「activator」

　　[★]

• n.

• 活性化因子、活性化薬、活性化剤、賦活薬、活性化物質、アクチベーター、アクティベーター