アルキルホスホコリン APCs
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/24 11:52:30」(JST)
[Wiki en表示]
Alkylphosphocholines are phospholipid-like molecules that have been synthesised, which have remarkable biological and therapeutic activities.[1][2] They are phosphocholine esters of aliphatic long chain alcohols differing in chain length, Unsaturation and position of the cis-double bond.[3]
References[edit]
- ^ Unger C, Sindermann H, Peukert M, Hilgard P, Engel J, Eibl H (1992). "Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients". Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progrès De La Recherche Expérimentale Des Tumeurs 34: 153–9. PMID 1438798.
- ^ Zeisig R, Jungmann S, Fichtner I, Daemen T, Arndt D (1994). "Cytotoxic effects of alkylphosphocholines or alkylphosphocholine-liposomes and macrophages on tumor cells". Anticancer Research 14 (5A): 1785–9. PMID 7847811.
- ^ Dieter Arndt, Reiner Zeisig, Ines Eue and Iduna Fichtner (1995). Alkylphosphocholines and Alkylphosphocholine Liposomes 5 (1). pp. 91–98. doi:10.3109/08982109509039910.
English Journal
- Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines.
- Gontijo VS1, Espuri PF2, Alves RB1, de Camargos LF3, Santos FV3, de Souza Judice WA4, Marques MJ2, Freitas RP5.
- European journal of medicinal chemistry.Eur J Med Chem.2015 Aug 28;101:24-33. doi: 10.1016/j.ejmech.2015.06.005. Epub 2015 Jun 5.
- PMID 26112378
- The influence of an antitumor lipid - erucylphosphocholine - on artificial lipid raft system modeled as Langmuir monolayer.
- Wnętrzak A1, Łątka K1, Makyła-Juzak K2, Zemla J1, Dynarowicz-Łątka P2.
- Molecular membrane biology.Mol Membr Biol.2015 Aug-Dec;32(5-8):189-97. doi: 10.3109/09687688.2015.1125537. Epub 2016 Feb 25.
- PMID 26911703
- Erufosine, a phosphoinositide-3-kinase inhibitor, to mitigate posterior capsule opacification in the human capsular bag model.
- Wertheimer C1, Brandlhuber U2, Kook D2, Mayer WJ2, Laubichler P2, Wolf A2, Kampik A2, Eibl-Lindner K2.
- Journal of cataract and refractive surgery.J Cataract Refract Surg.2015 Jul;41(7):1484-9. doi: 10.1016/j.jcrs.2015.02.034. Epub 2015 Jul 22.
- PMID 26210048
Related Links
- Alkylphosphocholines represent a new and exciting class of antineoplastic agents, discovered by Eibl and Unger, displaying numerous biological effects. The research presented in this volume focuses on the biological properties of ...
- To assess the effect of alkylphosphocholine (APC)-coated intraocular lenses (IOLs) on human lens epithelial cell (LEC) proliferation in vitro and the corneal b ... Figure 1. Cell number (mean ± SD) after incubation of the human LECs ...
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