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1. 血小板輸血療法の臨床上および検査上の特徴clinical and laboratory aspects of platelet transfusion therapy [show details]
… foreign. Production of anti-HLA antibodies can adversely affect the response to future platelet transfusions. The incidence of alloimmunization depends on the number of transfusions a patient has received. …
2. 血小板輸血療法に対する不応性refractoriness to platelet transfusion therapy [show details]
…demonstrate a blunted response compared with transfusion of ABO-identical platelets with decreased recovery but adequate survival . This blunted response should not be confused with alloimmunization. Another issue …
3. 顆粒球輸血granulocyte transfusions [show details]
… treatment plan, response to treatment, and donor availability. Complications of GTX include pulmonary reactions, transfusion-associated graft-versus-host disease, alloimmunization, and infection. …
4. 鎌状細胞貧血における臨床的ばらつきclinical variability in sickle cell anemia [show details]
… protective for alloimmunization while HLA-DR variants and alloimmunization did not reach statistical significance . In 44 alloimmunized and 128 non-alloimmunized Brazilians,… HbF levels also influence response to treatment with hydroxyurea (HU). Examples include: In one study, individuals with the best HbF response to HU were less likely…
5. 妊娠中の非Rh（D）RBC同種抗体のマネージメントmanagement of non rh d red blood cell alloantibodies during pregnancy [show details]
… reported to cause alloimmunization to Rh(D) in intravenous drug users; thus, exposure is considered a potential cause of sensitization to other RBC antigens . The likelihood of alloimmunization increases with …

Japanese Journal

iPS細胞からの血小板産生

臨床血液 59(10), 1905-1913, 2018
NAID 130007496699

iPS細胞を用いた新たな輸血医療

日本内科学会雑誌 106(4), 843-849, 2017
NAID 130006681925

「免疫」

　　[★]

英: immunity, immune
関: 免疫系

免疫の種類 (PT.246-251)

液性免疫(humoral immunity)と細胞性免疫がある。

	主に関与するリンパ球	働き	リンパ節での局在
細胞免疫	T細胞	(1)免疫の活性化	傍皮質
		(2)抗原を有する細胞への攻撃
液性免疫	B細胞	抗体産生	皮質

T細胞の種類

細胞の種類	補レセプター	抗原を提示する細胞	MHC抗原
キラーT細胞(Tc)	CD8	抗原提示細胞	MHCクラスI
ヘルパーT細胞(Th)	CD4	全ての細胞	MHCクラスII

ヘルパーT細胞の種類

T細胞	関連する因子	産生する物質	機能
Th1	IL-12 　増殖	IL-2,IFN-γなど	細胞性免疫を促進' 　(1)キラーT細胞、NK細胞、マクロファージを活性化　(2)遅延型過敏反応により自己免疫疾患に関与
Th2	IL-4 　Th→Th2	IL-4,IL-5,IL-6,IL-10など	液性免疫を促進' 　(1)B細胞、好酸球、肥満細胞に作用。　(2)即時型アレルギーに関与