vesicular GABA transporter

• 小胞GABA輸送体、小胞GABAトランスポーター

関

VGAT

WordNet

1. move something or somebody around; usually over long distances
2. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
3. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
4. transport commercially (同)send, ship
5. a long truck for carrying motor vehicles (同)car transporter
6. a crane for moving material with dispatch as in loading and unloading ships
7. of or relating to or involving vesicles; "normal vesicular breathing"

PrepTutorEJDIC

1. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
2. 自動車運搬用大型トラック
3. 小嚢の小胞の,小嚢(小胞)状の
4. General Admiral / (またGa)Georgia

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/20 18:05:12」(JST)

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SLC32A1
Identifiers
Aliases	SLC32A1, VGAT, VIAAT, solute carrier family 32 member 1
External IDs	MGI: 1194488 HomoloGene: 56451 GeneCards: SLC32A1
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.23 Start 38,724,462 bp End 38,729,372 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 158,610,767 bp End 158,615,748 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • gamma-aminobutyric acid:proton symporter activity • glycine transmembrane transporter activity • amino acid transmembrane transporter activity • vesicular hydrogen:amino acid antiporter activity Cellular component • integral component of membrane • membrane • synaptic vesicle • plasma membrane • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • synapse • inhibitory synapse • synaptic vesicle membrane • presynaptic active zone • dendrite terminus • dendrite • cone cell pedicle • intracellular organelle • cell tip • neuron projection • neuron projection terminus • cytoplasmic vesicle membrane • cytoplasmic vesicle • integral component of synaptic vesicle membrane Biological process • amino acid transmembrane transport • aging • ion transport • gamma-aminobutyric acid transport • neurotransmitter transport • hippocampus development • neurotransmitter secretion • glycine transport • amine transport • neurotransmitter loading into synaptic vesicle • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140679	22348
Ensembl	ENSG00000101438	ENSMUSG00000037771
UniProt	Q9H598	O35633
RefSeq (mRNA)	NM_080552	NM_009508
RefSeq (protein)	NP_542119	NP_033534
Location (UCSC)	Chr 20: 38.72 – 38.73 Mb	Chr 20: 158.61 – 158.62 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.

See also

• Solute carrier family

Further reading

• McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi:10.1038/39908. PMID 9349821. 
• Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi:10.2337/diabetes.51.6.1763. PMID 12031963. 
• Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi:10.1002/cne.10272. PMID 12115694. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. 
• Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi:10.1159/000070897. PMID 12806177. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334. 

UpToDate Contents

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English Journal

• Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina.

• Pei Z1, Chen Q1, Koren D1, Giammarinaro B1, Acaron Ledesma H1, Wei W2.
• The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2015 Sep 23;35(38):13219-32. doi: 10.1523/JNEUROSCI.0933-15.2015.
• Direction selectivity of direction-selective ganglion cells (DSGCs) in the retina results from patterned excitatory and inhibitory inputs onto DSGCs during motion stimuli. The inhibitory inputs onto DSGCs are directionally tuned to the antipreferred (null) direction and therefore potently suppress s
• PMID 26400950

• Genes in the GABA Pathway Increase in the Lateral Thalamus of Sprague Dawley Rats During the Proestrus/Estrus Phase.

• Umorin M1, Stinson C1, Bellinger LL1, Kramer P1.
• Journal of cellular physiology.J Cell Physiol.2015 Sep 21. doi: 10.1002/jcp.25198. [Epub ahead of print]
• Pain can vary over the estrous cycle as a result of changes in estradiol concentration but the mechanism causing this variation is unclear. Because the thalamus is important in pain control, gene expression in the lateral thalamus (ventral posteromedial, ventral posterolateral, reticular thalamic nu
• PMID 26388520

• Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.

• Kim J1, Son Y1, Kim J2, Lee S1, Kang S1, Park K1, Kim SH1, Kim JC1, Kim J3, Takayama C3, Im HI4, Yang M5, Shin T6, Moon C7.
• International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.Int J Dev Neurosci.2015 Sep 19. pii: S0736-5748(15)30048-4. doi: 10.1016/j.ijdevneu.2015.08.009. [Epub ahead of print]
• γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter involved in synaptic plasticity. GABAergic transmission is also implicated in developmental and degenerative processes in the brain. The goal of the present study was to understand the developmental and degenerative regulation of GA
• PMID 26394279

Japanese Journal

• Lack of Molecular-Anatomical Evidence for GABAergic Influence on Axon Initial Segment of Cerebellar Purkinje Cells by the Pinceau Formation

• Iwakura Atsushi,Uchigashima Motokazu,Miyazaki Taisuke,Yamasaki Miwako,Watanabe Masahiko
• The Journal of Neuroscience 32(27), 9438-9448, 2012-07-04
• … Then we examined the expression of molecules involved in GABAergic signaling, including GABA synthetic enzyme glutamic acid decarboxylase (GAD), vesicular GABA transporter vesicular inhibitory amino acid transporter (VIAAT), cytomatrix active zone protein bassoon, GABA receptor GABA_[A]Rα1, and cell adhesion molecule neuroligin-2. …
• NAID 120005090597

• The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice

• Saito Kenzi,Kakizaki Toshikazu,Hayashi Ryotaro,Nishimaru Hiroshi,Furukawa Tomonori,Nakazato Yoichi,Takamori Shigeo,Ebihara Satoe,Uematsu Masakazu,Mishina Masayoshi,Miyazaki Jun-ichi,Yokoyama Minesuke,Konishi Shiro,Inoue Koichi,Fukuda Atsuo,Fukumoto Manabu,Nakamura Kenji,Obata Kunihiko,Yanagawa Yuchio
• Molecular Brain 3(40), 1-13, 2010-12-30
• NAID 120004898442

• GABA-containing sympathetic preganglionic neurons in rat thoracic spinal cord send their axons to the superior cervical ganglion.

• ITO Tetsufumi,HIOKI Hiroyuki,NAKAMURA Kouichi,TANAKA Yasuyo,NAKADE Hiroyuki,KANEKO Takeshi,IINO Satoshi,NOJYO Yoshiaki
• The Journal of comparative neurology 502(1), 113-125, 2007-05
• … GABA-containing fibers have been observed in the rat superior cervical ganglion (SCG) and,to a lesser extent, in the stellate ganglion (STG). … Thus,GABA-containing fibers in the ganglia are suggested to be of extraganglionic origin. … SinceGAD67-immunoreactive fibers were found not in the dorsal roots or ganglia, but in the ventralroots, GABA-containing fibers in the sympathetic ganglia were considered to originate from thespinal cord. …
• NAID 120000807637

Related Links

• AB5062P | Anti-Vesicular GABA Transporter (VGAT) Antibody

This Anti-Vesicular GABA Transporter (VGAT) Antibody is validated for use in ELISA, IF, IH, WB for the detection of Vesicular GABA Transporter (VGAT). ... Western Blot Analysis: Representative lot data. 1:500 dilution of this ...

• Vesicular GABA transporter (VGAT) Antibody 612-401-E53

Vesicular GABA transporter antibody recognizes Vesicular GABA Amino Acid Transporter (VGAT) which is responsible for transport of the inhibitory neurotransmitter into synaptic vesicles. The VGAT protein (also known as the ...

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★リンクテーブル★

リンク元	「小胞GABA輸送体」「小胞GABAトランスポーター」「VGAT」
関連記事	「GABA」「transport」「transporter」「GA」「vesicular」

「小胞GABA輸送体」

　　[★]

英

vesicular GABA transporter、VGAT

関

小胞GABAトランスポーター

「小胞GABAトランスポーター」

　　[★]

英

vesicular GABA transporter

関

小胞GABA輸送体

「VGAT」

　　[★]

• 小胞GABA輸送体

関

vesicular GABA transporter

「GABA」

　　[★]

butyl

英

γ-aminobutyric acid, γ-aminobutyrate, gamma aminobutyric acid

同

γ-アミノ酪酸、4-アミノ酪酸、γ-アミノ酪酸、γアミノ酪酸、ガンマアミノブチル酸

関

GABA受容体。ブチル

• アミノ酸からなる
• 抑制性神経伝達物質

構造

• 4炭素の炭化水素 butaneのカルボン酸 butyric acidをベースとして、γ位(カルボン酸の炭素につながっている炭素がα位)にアミノ基がついた構造

生合成

• グルタミン酸にグルタミン脱炭酸酵素が作用しγ-アミノ酪酸が生成する(補酵素：PLP) (SPC.77)

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein

　 　 　

「GA」

　　[★]

• グリコアルブミン glycosylated albumin

　

「vesicular」

　　[★]

• adj.

• 小胞の

関

vesicle