関: VEGF-B

WordNet

cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
become attached by or as if by the process of growth; "The tree trunks had grown together"
become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
cause to grow or develop; "He grows vegetables in his backyard"
increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
(pathology) an abnormal proliferation of tissue (as in a tumor)
a progression from simpler to more complex forms; "the growth of culture"
something grown or growing; "a growth of hair"
vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

PrepTutorEJDIC

『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/25 08:45:04」(JST)

wiki en

Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene.^[1] VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.

Function

In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions.^[2] VEGF-B plays also an important role on several types of neurons. It is important for the protection of neurons in the retina^[3] and the cerebral cortex during stroke ^[4] and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.^[5]

VEGF-B exerts its effects via the FLT1 receptor.^[6]

VEGF-B has also been found to control endothelial uptake and transport of fatty acids in heart and skeletal muscle.^[7]^[8]

Interactions

Vascular endothelial growth factor B has been shown to interact with FLT1.^[9]^[10]

References

^ "Entrez Gene: VEGFB vascular endothelial growth factor B".
^ Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X (April 2009). "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (15): 6152–7. doi:10.1073/pnas.0813061106. PMC 2669337. PMID 19369214.
^ Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X (March 2008). "VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats". J. Clin. Invest. 118 (3): 913–23. doi:10.1172/JCI33673. PMC 2230661. PMID 18259607.
^ Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA (October 2004). "Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice". J. Cereb. Blood Flow Metab. 24 (10): 1146–52. doi:10.1097/01.wcb.0000134477.38980.38. PMID 15529014.
^ Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (October 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". J. Neurosci. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.
^ Yamazaki Y, Morita T (November 2006). "Molecular and functional diversity of vascular endothelial growth factors". Mol. Divers. 10 (4): 515–27. doi:10.1007/s11030-006-9027-3. PMID 16972015.
^ Muoio DM (July 2010). "Metabolism and vascular fatty acid transport". N. Engl. J. Med. 363 (3): 291–3. doi:10.1056/NEJMcibr1005397. PMID 20647206.
^ Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U (October 2012). "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes". Nature 490 (7420): 426–30. doi:10.1038/nature11464. PMID 23023133.
^ Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (September 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.
^ Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (July 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.

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English Journal

Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease.

Falk T, Yue X, Zhang S, McCourt AD, Yee BJ, Gonzalez RT, Sherman SJ.SourceDepartment of Neurology, College of Medicine, The University of Arizona, Tucson, AZ 85724, United States. tfalk@u.arizona.edu
Neuroscience letters.Neurosci Lett.2011 May 27;496(1):43-7. Epub 2011 Apr 12.
Developing novel neuroprotective strategies for the treatment of Parkinson's disease (PD) is of great importance. We have previously shown that vascular endothelial growth factor-B (VEGF-B) is up-regulated in an in vitro model of PD using the neurotoxin rotenone. Addition of exogenous VEGF-B(167) wa
PMID 21507340

The endothelium-dependent effect of RTEF-1 in pressure overload cardiac hypertrophy: role of VEGF-B.

Xu M, Jin Y, Song Q, Wu J, Philbrick MJ, Cully BL, An X, Guo L, Gao F, Li J.SourceDepartment of Physiology, Fourth Military Medical University, Xi'an, China.
Cardiovascular research.Cardiovasc Res.2011 May 1;90(2):325-34. Epub 2010 Dec 17.
AIMS: Related transcription enhancer factor-1 (RTEF-1) has previously been demonstrated to play an important role in both endothelial cells and cardiomyocytes. However, the function of RTEF-1 in the communication between these two adjacent cell types has not been elucidated.METHODS AND RESULTS: We h
PMID 21169295

Japanese Journal

肺高血圧症動物モデルからの知見 (特集肺高血圧症 : 初期診断・治療・管理のすべて)

内科 117(3), 479-483, 2016-03
NAID 40020799639

Vascular endothelial growth factor regulates growth of endometrial tissues and angiogenesis in a mouse transplantation model

The Kitasato medical journal 46(1), 15-23, 2016-03
NAID 40020778259

CLINICAL INVESTIGATION : Effect of leaking capillaries and microaneurysms in the perifoveal capillary network on resolution of macular edema by anti-vascular endothelial growth factor treatment

Japanese journal of ophthalmology : the official international journal of the Japanese Ophthalmological Society 60(2), 86-94, 2016-03
NAID 40020763448

「血管内皮増殖因子B」

Vascular endothelial growth factor B
	; PDB rendering based on 2c7w.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2C7W, 2VWE, 2XAC
Identifiers
Symbols	VEGFB ; VEGFL; VRF
External IDs	OMIM: 601398 MGI: 106199 HomoloGene: 87131 GeneCards: VEGFB Gene
Gene ontology
Molecular function	• protein binding; • growth factor activity; • heparin binding; • chemoattractant activity; • protein homodimerization activity; • vascular endothelial growth factor receptor 1 binding; • protein heterodimerization activity;
Cellular component	• extracellular region; • extracellular space; • membrane; • platelet alpha granule lumen;
Biological process	• angiogenesis; • positive regulation of endothelial cell proliferation; • platelet degranulation; • protein O-linked glycosylation; • blood coagulation; • negative regulation of gene expression; • platelet activation; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of vascular wound healing; • response to drug; • negative regulation of apoptotic process; • positive regulation of vascular permeability; • negative regulation of neuron apoptotic process; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of peptidyl-tyrosine phosphorylation; • positive chemotaxis; • induction of positive chemotaxis; • positive regulation of cell division; • positive regulation of protein kinase B signaling; • cardiac muscle contraction; • positive regulation of mast cell chemotaxis; • coronary vasculature development; • positive regulation of ERK1 and ERK2 cascade;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: vascular endothelial growth factor B、VEGF-B
関: 血管内皮細胞増殖因子B

「血管内皮細胞増殖因子B」

　　[★]

英: vascular endothelial growth factor B
関: 血管内皮増殖因子B

「VEGF-B」

　　[★]

血管内皮増殖因子B

関: vascular endothelial growth factor B

「B」

　　[★]

気管分岐部下緑
補体のalternative pathwayに関わる蛋白質

Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

「grow」

　　[★]

v.

(過去: grew-過去分詞: grown)

成長する、生育する、伸びる

関: extend、growth、outgrow、outgrowth、stretch

「vascular」

　　[★]

adj.

(生物・解剖)導管の、脈管の、血管の

関: angio、blood vessel、fibrovascular bundle、vascular bundle、vasculogenic、vein、vessel

「fact」

　　[★]

n.

事実、現状、実際、実態

関: actual、actually、in fact、in practice、indeed、practically

「factor」

　　[★]

n.

因子、要因、要素、ファクター

関: element、elementary、factorial、parameter

[entrez-1] "Entrez Gene: VEGFB vascular endothelial growth factor B".

[pmid19369214-2] Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X (April 2009). "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (15): 6152–7. doi:10.1073/pnas.0813061106. PMC 2669337. PMID 19369214.

[pmid18259607-3] Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X (March 2008). "VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats". J. Clin. Invest. 118 (3): 913–23. doi:10.1172/JCI33673. PMC 2230661. PMID 18259607.

[pmid15529014-4] Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA (October 2004). "Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice". J. Cereb. Blood Flow Metab. 24 (10): 1146–52. doi:10.1097/01.wcb.0000134477.38980.38. PMID 15529014.

[pmid18923022-5] Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (October 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". J. Neurosci. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.

[pmid16972015-6] Yamazaki Y, Morita T (November 2006). "Molecular and functional diversity of vascular endothelial growth factors". Mol. Divers. 10 (4): 515–27. doi:10.1007/s11030-006-9027-3. PMID 16972015.

[pmid20647206-7] Muoio DM (July 2010). "Metabolism and vascular fatty acid transport". N. Engl. J. Med. 363 (3): 291–3. doi:10.1056/NEJMcibr1005397. PMID 20647206.

[pmid23023133-8] Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U (October 2012). "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes". Nature 490 (7420): 426–30. doi:10.1038/nature11464. PMID 23023133.

[pmid9751730-9] Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (September 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.

[pmid10409677-10] Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (July 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.

リンク元	「血管内皮増殖因子B」「血管内皮細胞増殖因子B」「VEGF-B」
関連記事	「B」「grow」「vascular」「fact」「factor」

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案内

vascular endothelial growth factor B