I型DNAト・イソメラーゼ、DNAト・イソメラーゼI
- 関
- DNA topoisomerase、DNA topoisomerase I、topoisomerase I
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- the 9th letter of the Roman alphabet (同)i
- the 4th letter of the Roman alphabet (同)d
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- 『私は』私が
- iodineの化学記号
- deuteriumの化学記号
- deoxyribonucleic acidディオキシリボ核酸
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/26 05:30:45」(JST)
[Wiki en表示]
DNA topoisomerase |
Identifiers |
EC number |
5.99.1.2 |
CAS number |
80449-01-0 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
DNA topoisomerase (EC 5.99.1.2, type I DNA topoisomerase, untwisting enzyme, relaxing enzyme, nicking-closing enzyme, swivelase, omega-protein, deoxyribonucleate topoisomerase) is an enzyme with system name DNA topoisomerase.[1] This enzyme catalyses the following chemical reaction
- ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
These enzymes bring about the conversion of one topological isomer of DNA into another.
References[edit]
- ^ Gellert, M. (1981). "DNA topoisomerases". Annu. Rev. Biochem. 50: 879–910. PMID 6267993.
See also[edit]
External links[edit]
- DNA topoisomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
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English Journal
- p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells.
- Montariello D, Troiano A, Malanga M, Calabrò V, Quesada P.SourceDepartment of Biology, University of Naples Federico II, Italy.
- Biochemical pharmacology.Biochem Pharmacol.2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
- Poly(ADP-ribose)polymerase 1 (PARP-1) inhibitors are thought as breakthrough for cancer treatment in solid tumors such as breast cancer through their effects on PARP's enzymatic activity. Our previous findings showed that the hydrophilic PARP inhibitor PJ34 enhances the sensitivity of p53 proficient
- PMID 23376119
- Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA.
- Williams JS, Smith DJ, Marjavaara L, Lujan SA, Chabes A, Kunkel TA.SourceLaboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.
- Molecular cell.Mol Cell.2013 Mar 7;49(5):1010-5. doi: 10.1016/j.molcel.2012.12.021. Epub 2013 Jan 31.
- RNase H2-dependent ribonucleotide excision repair (RER) removes ribonucleotides incorporated during DNA replication. When RER is defective, ribonucleotides in the nascent leading strand of the yeast genome are associated with replication stress and genome instability. Here, we provide evidence that
- PMID 23375499
- Transcription-dependent dynamic supercoiling is a short-range genomic force.
- Kouzine F, Gupta A, Baranello L, Wojtowicz D, Ben-Aissa K, Liu J, Przytycka TM, Levens D.SourceLaboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.
- Nature structural & molecular biology.Nat Struct Mol Biol.2013 Mar;20(3):396-403. doi: 10.1038/nsmb.2517. Epub 2013 Feb 17.
- Transcription has the capacity to mechanically modify DNA topology, DNA structure and nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn may provide instant feedback to the transcription machinery. To substantiate the connection between transcription and DNA dy
- PMID 23416947
Japanese Journal
- Nuclear dynamics of topoisomerase II beta reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
- An Easy-to-use Genotoxicity Assay Using EGFP-MDC1-expressing Human Cells
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 36(3), 139-147, 2013-06-30
- NAID 10031185520
Related Links
- I. Introduction DNA topoisomerases are a class of enzymes involved in the regulation of DNA supercoiling. Type I topoisomerases change the degree of supercoiling of DNA by causing single-strand breaks and re-ligation, whereas type II ...
- In order to perform unraveling of a "compensating winding up" DNA, enzymes are required (1). Topoisomerase changes the linking number as well as catalyzes the interconversionn of other kinds of topological isomers of DNA (2). ...
Related Pictures
★リンクテーブル★
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- 英
- DNA topoisomerase I、type I DNA topoisomerase
- 関
- DNAトポイソメラーゼ、I型DNAトポイソメラーゼ、トポイソメラーゼI
[★]
- 英
- type I DNA topoisomerase
- 関
- DNAトポイソメラーゼ、DNAトポイソメラーゼI、トポイソメラーゼI
[★]
ト・イソメラーゼI
- 関
- DNA topoisomerase、DNA topoisomerase I、type I DNA topoisomerase
[★]
DNAトポイソメラーゼ
- 関
- DNA topoisomerase I、topoisomerase I、type I DNA topoisomerase
[★]
DNAト・イソメラーゼI
- 関
- DNA topoisomerase、topoisomerase I、type I DNA topoisomerase
[★]
- 関
- eukaryotic topoisomerase I
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[★]
[★]
- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
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[★]
DNAトポイソメラーゼ
- 関
- DNA topoisomerase I、topoisomerase I、type I DNA topoisomerase
[★]
- 英
- deoxyribonucleic acid
- 同
- デオキシリボ核酸
- 関
- リボ核酸 RNA