- 関
- TGF-beta receptor、TGFBR
WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
- come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
- become attached by or as if by the process of growth; "The tree trunks had grown together"
- become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
- cause to grow or develop; "He grows vegetables in his backyard"
- increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
- (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
- (pathology) an abnormal proliferation of tissue (as in a tumor)
- a progression from simpler to more complex forms; "the growth of culture"
- something grown or growing; "a growth of hair"
- vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
- 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/07 23:27:29」(JST)
[Wiki en表示]
transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa) |
Identifiers |
Symbol |
TGFBR1 |
Entrez |
7046 |
HUGO |
11772 |
OMIM |
190181 |
RefSeq |
NM_004612 |
UniProt |
P36897 |
Other data |
Locus |
Chr. 9 q22 |
transforming growth factor beta, receptor type II (70/80kDa) |
Identifiers |
Symbol |
TGFBR2 |
Alt. symbols |
MFS2 |
Entrez |
7048 |
HUGO |
11773 |
OMIM |
190182 |
RefSeq |
NM_001024847 |
UniProt |
P37173 |
Other data |
Locus |
Chr. 3 p22 |
transforming growth factor beta, receptor type III |
Identifiers |
Symbol |
TGFBR3 |
Entrez |
7049 |
HUGO |
11774 |
OMIM |
600742 |
RefSeq |
NM_003243 |
UniProt |
Q03167 |
Other data |
Locus |
Chr. 1 p33-p32 |
TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric.[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.
TGF (Transforming Growth Factor) are involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, and testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.
Contents
- 1 Classification
- 2 Types
- 3 References
- 4 External links
Classification
Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2.[2]
Types
- TGF beta receptor 1
- TGF beta receptor 2
- TGF beta receptor 3
References
- ^ Doré Jr, J. J.; Edens, M.; Garamszegi, N.; Leof, E. B. (1998). "Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells". The Journal of biological chemistry 273 (48): 31770–31777. doi:10.1074/jbc.273.48.31770. PMID 9822641. (free full text)
- ^ Cheifetz, S.; Andres, J. L.; Massagué, J. (1988). "The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor". The Journal of biological chemistry 263 (32): 16984–16991. PMID 2903157.
External links
- TGF-beta Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell signaling: TGF beta signaling pathway
|
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TGF beta superfamily of ligands |
TGF beta family
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Bone morphogenetic proteins
|
- BMP2
- BMP3
- BMP4
- BMP5
- BMP6
- BMP7
- BMP8a
- BMP8b
- BMP10
- BMP15
|
|
Growth differentiation factors
|
- GDF1
- GDF2
- GDF3
- GDF5
- GDF6
- GDF7
- Myostatin/GDF8
- GDF9
- GDF10
- GDF11
- GDF15
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Other
|
- Activin and inhibin
- Anti-müllerian hormone
- Nodal
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TGF beta receptors
(Activin, BMP) |
TGFBR1:
|
- Activin type 1 receptors
- ACVRL1
- BMPR1
|
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TGFBR2:
|
- Activin type 2 receptors
- AMHR2
- BMPR2
|
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TGFBR3:
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Transducers/SMAD |
- R-SMAD (SMAD1
- SMAD2
- SMAD3
- SMAD5
- SMAD9)
- I-SMAD (SMAD6
- SMAD7)
- SMAD4
|
|
Ligand inhibitors |
- Cerberus
- Chordin
- Decorin
- Follistatin
- Gremlin
- Lefty
- LTBP1
- Noggin
- PARN
- THBS1
|
|
Coreceptors |
|
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Other |
|
|
Index of signal transduction
|
|
Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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|
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Receptors: growth factor receptors
|
|
Type I cytokine receptor |
- Nerve growth factors: Ciliary neurotrophic factor
- Erythropoietin
|
|
Receptor protein serine/threonine kinase |
- TGF pathway: TGF-beta
- Activin
- Bone morphogenetic protein
|
|
Receptor tyrosine kinase |
|
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- Nerve growth factors: high affinity Trk
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|
|
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- Somatomedin
- Insulin-like growth factor 1
|
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- ErbB/Epidermal growth factor
|
|
|
|
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Tumor necrosis factor receptor |
- Nerve growth factors: Low affinity/p75
|
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Ig superfamily |
- Platelet-derived growth factor
- Stem cell factor
|
|
Other/ungrouped |
- Somatomedin
- Insulin-like growth factor 2
|
|
Index of signal transduction
|
|
Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
|
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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Polo kinase (EC 2.7.11.21) |
|
|
Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDC2L5
- CRKRS
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
|
|
(RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
|
|
Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
|
|
MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
|
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Tau-protein kinase (EC 2.7.11.26) |
|
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(acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
|
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Tropomyosin kinase (EC 2.7.11.28) |
|
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
|
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Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
|
|
MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
|
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Enhanced effect of β-tricalcium phosphate phase on neovascularization of porous calcium phosphate ceramics: In vitro and in vivo evidence.
- Chen Y1, Wang J1, Zhu XD2, Tang ZR1, Yang X1, Tan YF1, Fan YJ1, Zhang XD3.
- Acta biomaterialia.Acta Biomater.2015 Jan 1;11:435-48. doi: 10.1016/j.actbio.2014.09.028. Epub 2014 Sep 22.
- Neovascularization plays a key role in bone repair and regeneration. In the present study, four types of porous calcium phosphate (CaP) ceramics, namely hydroxyapatite (HA), biphasic calcium phosphates (BCP-1 and BCP-2) and β-tricalcium phosphate (β-TCP), with HA to β-TCP ratios of 100/0, 70/30,
- PMID 25246313
- Expression and significance of transforming growth factor-β receptor type II and DPC4/Smad4 in non-small cell lung cancer.
- Chen H1, Wang JW2, Liu LX2, Yan JD2, Ren SH2, Li Y2, Lu Z2.
- Experimental and therapeutic medicine.Exp Ther Med.2015 Jan;9(1):227-231. Epub 2014 Nov 12.
- The aim of the present study was to investigate the expression levels of transforming growth factor-β (TGF-β) receptor type II (TβRII) and DPC4/Smad4 in the TGF-β signaling pathway and the importance of these expression levels in non-small cell lung cancer (NSCLC). The mRNA and protein expressio
- PMID 25452807
- Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.
- Accornero F1, Kanisicak O1, Tjondrokoesoemo A1, Attia AC1, McNally EM2, Molkentin JD3.
- Human molecular genetics.Hum Mol Genet.2014 Dec 20;23(25):6903-15. doi: 10.1093/hmg/ddu413. Epub 2014 Aug 8.
- Muscular dystrophy (MD) is a disease characterized by skeletal muscle necrosis and the progressive accumulation of fibrotic tissue. While transforming growth factor (TGF)-β has emerged as central effector of MD and fibrotic disease, the cell types in diseased muscle that underlie TGFβ-dependent pa
- PMID 25106553
Japanese Journal
- Bone Morphogenetic Proteins Are Mediators of Luteolysis in the Human Corpus Luteum
- O-9 蛋白尿惹起液性因子soluble urokinase receptor (suPAR)および間質障害に関連するTGF-βに対するLDLアフェレシス施行の影響(腎疾患(1),一般演題3,第35回日本アフェレシス学会学術大会)
- VEGFR1 signaling facilitates diabetic skin wound healing in mice
Related Links
- TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric. The number of characterized ligands in the TGFβ superfamily far exceeds the number of known ...
★リンクテーブル★
[★]
- 英
- transforming growth factor beta receptor、TGFBR
- 関
- TGFβ受容体、形質転換増殖因子β受容体、TGF-β受容体
[★]
- 英
- transforming growth factor beta receptor
- 関
- トランスフォーミング増殖因子β受容体
[★]
- 関
- transforming growth factor beta receptor
[★]
- 関
- transforming growth factor beta receptor
[★]
- (過去: grew-過去分詞: grown)
- 関
- extend、growth、outgrow、outgrowth、stretch
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
- 関
- transform、transformation、transgenic
[★]