緩徐進行1型糖尿病
WordNet
- not moving quickly; taking a comparatively long time; "a slow walker"; "the slow lane of traffic"; "her steps were slow"; "he was slow in reacting to the news"; "slow but steady growth"
- cause to proceed more slowly; "The illness slowed him down" (同)slow down, slow up
- become slow or slower; "Production slowed" (同)slow down, slow up, slack, slacken
- (used of timepieces) indicating a time earlier than the correct time; "the clock is slow"
- at a slow tempo; "the band played a slow waltz"
- gradually advancing in extent
- a tense of verbs used in describing action that is on-going (同)progressive tense, imperfect, imperfect tense, continuous tense
- favoring or promoting reform (often by government action) (同)reformist, reform-minded
- (of a card game or a dance) involving a series of sections for which the participants successively change place or relative position; "progressive euchre"; "progressive tournaments"
- (of taxes) adjusted so that the rate increases as the amount of income increases
- advancing in severity; "progressive paralysis"
- favoring or promoting progress; "progressive schools"
- relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
- addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
- contingent on something else (同)dependant, qualified
- (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
- a polygenic disease characterized by abnormally high glucose levels in the blood; any of several metabolic disorders marked by excessive urination and persistent thirst
- hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells
PrepTutorEJDIC
- (速度・動作などが)『遅い』,のろい / 《補語または名詞の後にのみ用いて》(時計などが)『遅れている』 / 『ゆったりした』,あわてない / (人が)理解の遅い,頭の鈍い / (生活・パーティーなどが)『活気のない』,おもしろくない / 遅く,ゆっくり(slowly) / 『遅くなる』,速度を落とす《+『down』(『up』)》 / …‘を'『遅くする』,‘の'速度を落とす《+『名』+『down』(『up』),+『down』(『up』)+『名』》
- (行列などが)『前進する』,進んで行く / (事態が)進展する,進行する / 『進歩的な』,革新的な / (病気・暴力などが)次第に悪くなる(広がる) / (課税が)累進的な / (文法で)進行[形]の / 進歩的な人,革新主義者
- 『頼っている』,依存している,従属している / 扶養される人(家族)
- 糖尿病(尿に糖が異常に出る病気)
- インシュリン(膵臓(すいぞう)ホルモンで糖尿病治療剤)
UpToDate Contents
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English Journal
- Evaluation of insulin secretion and sensitivity in a patient with slowly progressive type 1 diabetes mellitus.
- Ishizuka T1, Tokuyama Y, Kanatsuka A.Author information 1Credo Sato Clinic, Japan.AbstractWe herein report the case of a patient with slowly progressive type 1 diabetes and insulin independence lasting for >10 years despite the detection of continuously elevated glutamic acid decarboxylase autoantibody titers. We monitored the patient's clinical course and analyzed his endogenous insulin secretion and sensitivity using an intravenous glucose tolerance test (IVGTT) and oral glucose tolerance test (OGTT). His body mass index remained at approximately 22, while his serum C-peptide immunoreactivity level gradually decreased. The level of insulin secretion was significantly higher on the OGTT than the IVGTT. The patient's insulin sensitivity was within the normal limits. These results suggest that maintaining a lifestyle sufficient to preserve insulin secretion and/or normal insulin sensitivity is important and that β-cell responsiveness to incretins may, in part, contribute to insulin independence.
- Internal medicine (Tokyo, Japan).Intern Med.2013;52(24):2777-80.
- We herein report the case of a patient with slowly progressive type 1 diabetes and insulin independence lasting for >10 years despite the detection of continuously elevated glutamic acid decarboxylase autoantibody titers. We monitored the patient's clinical course and analyzed his endogenous insu
- PMID 24334584
- [Latent autoimmune diabetes in adults].
- Pollak F1, Vásquez T.Author information 1Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile. fpollak@med.puc.clAbstractLatent Autoimmune Diabetes in Adults (LADA) is the term used to describe adults who have a slowly progressive form of diabetes mellitus (DM) of autoimmune etiology, but that may be treated initially without insulin. Although it shares some immunological and genetic aspects with type 1 DM, it affects an age group that is typically affected by type 2 DM. Therefore, it could be considered an intermediate type. Diagnosis is based on clinical and laboratory criteria: age of onset, initial response to oral hypoglycemic agents and the presence of specific antibodies for diabetes. Although the definitive treatment is insulin, glitazones may be useful in early stages of the disease. Currently, its management represents a challenge for the physician, including specialists, and it is a form of DM to keep in mind.
- Revista médica de Chile.Rev Med Chil.2012 Nov;140(11):1476-81. doi: 10.4067/S0034-98872012001100015.
- Latent Autoimmune Diabetes in Adults (LADA) is the term used to describe adults who have a slowly progressive form of diabetes mellitus (DM) of autoimmune etiology, but that may be treated initially without insulin. Although it shares some immunological and genetic aspects with type 1 DM, it affects
- PMID 23677196
- Screening and treatment of childhood type 1 and type 2 diabetes mellitus in Japan.
- Urakami T1, Suzuki J, Mugishima H, Amemiya S, Sugihara S, Kawamura T, Kikuchi T, Sasaki N, Matsuura N, Kitagawa T.Author information 1Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan. urakami.tatsuhiko@nihon-u.ac.jpAbstractA large number of children with type 2 diabetes mellitus (T2DM) and a small number with a slowly progressive form of type 1 diabetes mellitus (SPT1DM) have been detected by a urine glucose screening program conducted at Japanese schools since 1974. The incidence of T2DM in children has increased over the last 3 decades and is estimated to be approximately 3.0/100,000/year, which is twice as that of T1DM. In contrast, SPT1DM in children is more prevalent in Asians, particularly Japanese, and exhibits unique clinical features that differ from those of the rapid onset form of T1DM, usually seen in Caucasians. In the first part of this review, we summarize the urine glucose screening program conducted at Japanese schools and clinical characteristics of the 2 diabetic subtypes in Japanese children. In recent years, concerns regarding childhood diabetes in Asian countries, including Japan, have risen, and medical care for the same is exceedingly developing. Intensive insulin therapy such as basal-bolus therapy by multiple daily insulin injections and pump therapy, both using insulin analogs, has been increasing in pediatric patients with T1DM. In addition, various antidiabetic medications have been introduced for children with T2DM. In the second part of this review, we describe treatment of Japanese children with T1DM and T2DM and changes in glycemic control as a result of development of the treatment.
- Pediatric endocrinology reviews : PER.Pediatr Endocrinol Rev.2012 Oct;10 Suppl 1:51-61.
- A large number of children with type 2 diabetes mellitus (T2DM) and a small number with a slowly progressive form of type 1 diabetes mellitus (SPT1DM) have been detected by a urine glucose screening program conducted at Japanese schools since 1974. The incidence of T2DM in children has increased ove
- PMID 23330246
Japanese Journal
- 内因性インスリン分泌が緩徐に枯渇していった肥満2型糖尿病の一例
- 杉沢 恵里,花井 豪,丸山 聡子,石井 晶子,三浦 順之助,内潟 安子,岩本 安彦
- 東京女子医科大学雑誌 81(E2), E237-E240, 2011-03-31
- 症例は57歳、女性.1983年(31歳)、8月糖尿病と診断され、グリベンクラミド5mgが開始された.食事負荷試験(MTT)では追加分泌の低下を認めた.同年9月インスリン1回法が開始.同年11月、インスリン2回法に変更.32歳時、妊娠が判明. 33歳、尿ケトンが3+となることが多くなったが、同年無事出産.出産後のMTTでは基礎分泌も枯渇に近い状態であった.34歳、尿ケトン1+程度となった.49歳時、 …
- NAID 110008441474
- 膵島所見を観察しえた緩徐進行1型糖尿病の一例 : 過去の報告例とまとめ
- 佐々木 衛,東 宏一郎,小澤 裕理,森本 二郎,鈴木 裕也,丸山 太郎
- 糖尿病 54(3), 187-191, 2011-03-30
- NAID 10029746242
Related Links
- 8 Apr 2008 ... Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus. Maruyama T, Tanaka S, Shimada A, Funae O, Kasuga A, Kanatsuka A, Takei I, Yamada S, Harii N, Shimura H, Kobayashi T.
- Progression of autoimmune diabetes: slowly progressive insulin-dependent diabetes mellitus or latent autoimmune diabetes of adult. Beyan H, Ola T, David R, Leslie G. Institute of Cell and Molecular Science, Centre for Diabetes & Metabolic ...
★リンクテーブル★
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- 英
- slowly progressive insulin dependent diabetes mellitus, slowly progressive IDDM, SPIDDM
- 関
- 1型糖尿病、糖尿病
臨床的特徴
- DMR.30 参考1
臨床像
- 急性発症1型糖尿病のGAD抗体とSPIDDMのそれとは異なり、N末端側にユニークなエピトープを有する。
- 発症年齢は30-50歳と中年から高齢である。 ⇔ 急性発症1型糖尿病は若年期
- β細胞障害の速度は女性に比べ男性のほうが早い。
- HLA type
- Class II MHC であるHLA-DR4-DQA1*0301-B1*0401との関連がある。
- 急性発症1型糖尿病と関連するHLA-A24 との関連は薄い。
膵組織
- 膵β細胞がわずかに残存
- 膵外分泌腺組織は著明に萎縮
- 膵島周囲にCD8陽性Tリンパ球浸潤(periinsulitis)が認められる。 ← 膵島炎は稀(DMR.30)
- 膵外分泌腺へのCD8陽性Tリンパ球もしくはCD4 陽性Tリンパ球の浸潤が認められることがある。
- 膵管造影で膵管、とくに二次膵管の慢性膵炎様の不整所見を認める頻度が高い。主膵管の拡張、不整。
参考
- 1. 緩徐進行1 型糖尿病(SPIDDM), 月刊糖尿病 2009/11 Vol.1 No.6, p.50
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緩徐進行性インスリン依存糖尿病、SPIDDM
[★]
- (比較級slower-最上級slowest)緩徐な、遅い、ゆっくりとした、緩慢な
- 関
- gradual、gradually、late、slowly、sluggish
[★]
- 関
- depend、dependence、dependency、dependently
[★]
- 関
- gradual、gradually、slow
[★]
- 関
- progressively
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- 関
- 糖尿病 diabetes mellitus DM