WordNet
- place signs, as along a road; "sign an intersection"; "This road has been signed"
- (medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
- a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
- a character indicating a relation between quantities; "dont forget the minus sign"
- a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
- a gesture that is part of a sign language
- a public display of a message; "he posted signs in all the shop windows"
- engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
- approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
- communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
- mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
- be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
- communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
- notably out of the ordinary; "the year saw one signal triumph for the Labour party"
- an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
- any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
- any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
- (genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
- a sound or television recording (e.g., from a broadcast to a tape recording)
- something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text
PrepTutorEJDIC
- (ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
- 《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
- (警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
- 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
- 〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)
UpToDate Contents
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- 1. 複合免疫不全 combined immunodeficiencies
- 2. IgEの生物学 the biology of ige
- 3. アスピリンによる呼吸器疾患の増悪 aspirin exacerbated respiratory disease
- 4. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
- 5. Solitary fibrous tumor
English Journal
- The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells.
- Hu M1, Ye W, Li J, Zhou P, Chu Z, Huang W.
- Anti-cancer drugs.Anticancer Drugs.2016 Jan;27(1):41-7. doi: 10.1097/CAD.0000000000000303.
- The signal transducer and activator of transcription 3 (STAT3) is constitutively activated in certain cancer cells. Therefore, blocking the aberrant activity of STAT3 in tumor cells is a validated therapeutic strategy. To discover novel inhibitors of STAT3 activity, we report the salicylanilide deri
- PMID 26469835
- Signal transducer and activator of transcription 3: a year in review.
- Forbes LR1, Milner J, Haddad E.
- Current opinion in hematology.Curr Opin Hematol.2016 Jan;23(1):23-7. doi: 10.1097/MOH.0000000000000206.
- PURPOSE OF REVIEW: Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in a wide variety of cellular functions. Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas soma
- PMID 26574998
- Airway inflammation in asthma: key players beyond the Th2 pathway.
- KleinJan A1.
- Current opinion in pulmonary medicine.Curr Opin Pulm Med.2016 Jan;22(1):46-52. doi: 10.1097/MCP.0000000000000224.
- PURPOSE OF REVIEW: The Th2 pathway starts with the binding of IL-4 to the IL-4 receptor followed by the phosphorylation of signal transducer and activator of transcription 6 and the activation of GATA3. The most important question relates to the sources of IL-4 and IL-4 related inflammation. Which c
- PMID 26574718
Japanese Journal
- Interleukin-18 and Interleukin-12 Together Downregulate ATP-Binding Cassette Transporter A1 Expression Through the Interleukin-18R/Nuclear Factor-κB Signaling Pathway in THP-1 Macrophage-Derived Foam Cells
- YU Xiao-Hua,JIANG Hai-Lu,CHEN Wu-Jun,YIN Kai,ZHAO Guo-Jun,MO Zhong-Cheng,OUYANG Xin-Ping,LV Yun-Cheng,JIANG Zhi-Sheng,ZHANG Da-Wei,TANG Chao-Ke
- Circulation journal : official journal of
- … Interleukin (IL)-18 and IL-12 synergize for the production of interferon (IFN)-γ, which can downregulate ATP-binding cassette transporter A1 (ABCA1) expression. … The aim of the present study was to investigate the effect of IL-18 and/or IL-12 on ABCA1 expression. … <b><i>Methods and Results:</i></b> …
- NAID 10030503888
- 胃炎発癌におけるSTAT3/REGシグナルの役割 (特集 炎症と消化器癌)
- 福井 広一,藤盛 孝博,富田 寿彦
- 消化器内科 54(6), 710-714, 2012-06
- NAID 40019386660
Related Links
- The STAT3 gene is part of a family known as the STAT genes. These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells. When STAT proteins are activated ...
- 1. J Allergy Clin Immunol. 2013 Jun;131(6):1624-34. doi: 10.1016/j.jaci.2013.01.052. Epub 2013 Mar 28. Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and ...
Related Pictures
★リンクテーブル★
| リンク元 | 「シグナル伝達性転写因子」「STAT」 |
| 関連記事 | 「sign」「transduce」「activator」「signaling」「transducer」 |
「シグナル伝達性転写因子」
「STAT」
[★] signal transducer and activator of transcription
「sign」
- n.
「transduce」
- v.
- 伝達する、形質導入する
「activator」
- n.
「signaling」
- n.
「transducer」
- n.
- トランスデューサー、変換器、振動子、送受波器