The tumor suppressive function of PTEN is exerted within 2 different cellular compartments. In the cytosol-membrane, it negatively regulates PI3K-AKT pathway through the de-phosphorylation of phosphatidylinositol (3,4,5)-triphosphate (PIP3), therefore blocking one of the major signaling transduction
Journal of molecular biology.J Mol Biol.2014 Jul 29;426(15):2717-35. doi: 10.1016/j.jmb.2014.05.016. Epub 2014 May 22.
The exceptional versatility of calmodulin (CaM) three-dimensional arrangement is reflected in the growing number of structural models of CaM/protein complexes currently available in the Protein Data Bank (PDB) database, revealing a great diversity of conformations, domain organization, and structura
Requisites for successful theranostics with radionuclide-based reporter gene imaging.
Journal of drug targeting.J Drug Target.2014 May;22(4):295-303. doi: 10.3109/1061186X.2013.878940. Epub 2014 Jan 13.
Radionuclide-based theranostic strategy has been widely used in diagnosis and treatment of patients with hyperthyroidism or differentiated thyroid cancer for a long time, and sodium iodide symporter gene is the radionuclide-based reporter gene used in theranostics. Theranostics, which is a promising
Adenovirus Vector Covalently Conjugated to Polyethylene Glycol with a Cancer-Specific Promoter Suppresses the Tumor Growth through Systemic Administration
Yao Xinglei,Yoshioka Yasuo,Morishige Tomohiro,Eto Yusuke,Narimatsu Shogo,Mizuguchi Hiroyuki,Mukai Yohei,Okada Naoki,Nakagawa Shinsaku
Biological and Pharmaceutical Bulletin 33(6), 1073-1076, 2010
… Previously, we generated a dual cancer-specific Adv system by using Adv covalently conjugated to polyethylene glycol (PEG) for transductional targeting and the telomere reverse transcriptase (TERT) promoter as a cancer-specific promoter for transcriptional targeting (PEG-Ad-TERT). …
Strategies to enhance transductional efficiency of adenoviral-based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal wounds
STOFF Alexander,RIVERA Angel A.,BANERJEE N. S.,MATHIS J. Michael,ESPINOSA-DE-LOS-MONTEROS Antonio,LE Long P.,DE LA TORRE Jorge I.,VASCONEZ Luis O.,BROKER Thomas R.,RICHTER Dirk F.,STOFF-KHALILI Mariam A.,CURIEL David T.
Wound repair and regeneration 14(5), 608-617, 2006-09-01
trans·duc·tion (tr ns-d k sh n, tr nz-). n. Transfer of genetic material or characteristics from one bacterial cell to another by the incorporation of bacterial DNA into a bacteriophage. [From Latin transductus, past participle of tr nsd cere, to transfer; ...
Transductional targeting involves modifying the specificity of viral coat protein, thus increasing entry into target cells while reducing ... Non-transductional targeting involves altering the genome of the virus so it can only replicate in cancer cells.