quinolone-resistant Streptococcus pneumoniae

キノロン系耐性肺炎球菌

WordNet

1. impervious to being affected; "resistant to the effects of heat"; "resistant to persuasion"
2. respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants
3. spherical Gram-positive bacteria occurring in pairs or chains; cause e.g. scarlet fever and tonsillitis (同)streptococci, strep

PrepTutorEJDIC

1. 抵抗力のある;(…に)抵抗する《+『to』+『名』》
2. 肺炎
3. 連鎖球菌

UpToDate Contents

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• 1. フルオロキノロン類、ドキシサイクリン、およびトリメトプリムスルファメトキサゾールに対する肺炎レンサ球菌の耐性 resistance of streptococcus pneumoniae to the fluoroquinolones doxycycline and trimethoprim sulfamethoxazole
• 2. フルオロキノロン類 fluoroquinolones
• 3. 侵襲性肺炎球菌（Streptococcus pneumoniae）感染症および菌血症 invasive pneumococcal streptococcus pneumoniae infections and bacteremia
• 4. β-ラクタム系抗菌薬に対する肺炎レンサ球菌の耐性 resistance of streptococcus pneumoniae to beta lactam antibiotics
• 5. 小児の肺炎球菌性肺炎 pneumococcal pneumonia in children

English Journal

• Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.

• Odagiri T1, Inagaki H, Sugimoto Y, Nagamochi M, Miyauchi RN, Kuroyanagi J, Kitamura T, Komoriya S, Takahashi H.
• Journal of medicinal chemistry.J Med Chem.2013 Mar 14;56(5):1974-83. doi: 10.1021/jm301650g. Epub 2013 Feb 25.
• Novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]- 8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 2a and 2b were designed and synthesized to obtain potent antibacterial drugs for the treatment of respiratory tract infections. Among these, compound
• PMID 23409972

• Functional analysis of pneumococcal drug efflux pumps associates the MATE DinF transporter with quinolone susceptibility.

• Tocci N1, Iannelli F, Bidossi A, Ciusa ML, Decorosi F, Viti C, Pozzi G, Ricci S, Oggioni MR.
• Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jan;57(1):248-53. doi: 10.1128/AAC.01298-12. Epub 2012 Oct 31.
• The pneumococcal chromosome encodes about 140 transporters, many of which are predicted to be involved in efflux. In order to critically evaluate pneumococcal efflux, a series of transporter mutants were constructed, and their phenotypes were assayed by disk diffusion, microdilution drug susceptibil
• PMID 23114782

• Novel DNA gyrase inhibitors: microbiological characterisation of pyrrolamides.

• Uria-Nickelsen M1, Blodgett A, Kamp H, Eakin A, Sherer B, Green O.
• International journal of antimicrobial agents.Int J Antimicrob Agents.2013 Jan;41(1):28-35. doi: 10.1016/j.ijantimicag.2012.08.017. Epub 2012 Nov 8.
• Pyrrolamides are a novel class of antibacterial agents that target DNA gyrase, resulting in inhibition of DNA synthesis and bacterial cell death. In these studies, advanced compounds were shown to have potent in vitro activity against selected Gram-positive and Gram-negative pathogens, including met
• PMID 23142086

Japanese Journal

• 多剤耐性肺炎球菌による呼吸器感染症および耳鼻咽喉科領域感染症に対する garenoxacin の臨床効果

• 河野 茂,小林 宏行,馬場 駿吉,高畑 正裕,Kohno Shigeru,Kobayashi Hiroyuki,Baba Shunkichi,Takahata Masahiro
• 日本化学療法学会雜誌 = Japanese journal of chemotherapy 55, 222-230, 2007-10-01
• … 新規な経口デスフルオロキノロン系抗菌薬であるgarenoxacin mesilate hydrate（GRNX）の呼吸器感染症および耳鼻咽喉科領域感染症を対象とした臨床試験（8試験）から，Streptococcus pneumoniaeを原因菌とする症例を対象として，原因菌の各種抗菌薬に対する感受性を測定し，多剤耐性肺炎球菌の同定，penicillin binding protein（PBP）遺伝子変異およびマクロライド耐性遺伝子の解析を行い，S. …
• NAID 10019948748

• The Incidence of Respiratory Tract Pathogens and Antimicrobial Susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella (Branhamella) catarrhalis Isolated between 1990 and 1993

• NISHIOKA KIYO,OGIHARA HISAKO,OHNO ISAO,TANNO YASUO,SHIRATO KUNIO
• Tohoku journal of experimental medicine 179(2), 111-121, 1996-06-01
• NAID 10024504526

Related Links

• Activities of Garenoxacin against Quinolone-Resistant ...

Streptococcus pneumoniae is the bacterium most frequently isolated from patients with community-acquired pneumonia and continues to be a significant cause of mortality (15, 16, 19). It colonizes the human nasopharynx and is a ...

• Relative Fitness of Fluoroquinolone-resistant Streptococcus ...

Fluoroquinolone resistance in Streptococcus pneumoniae is primarily mediated by point mutations in the quinolone resistance–determining regions of gyrA and parC. Antimicrobial resistance mutations in housekeeping genes often ...

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★リンクテーブル★

リンク元	「キノロン系耐性肺炎球菌」
関連記事	「Streptococcus pneumoniae」「resistant」「pneumoniae」

「キノロン系耐性肺炎球菌」

　　[★]

英

quinolone-resistant Streptococcus pneumoniae

関

キノロン系、肺炎球菌

「Streptococcus pneumoniae」

　　[★]

ラ

Streptococcus pneumoniae

同

肺炎球菌、肺炎レンサ球菌、肺炎連鎖球菌、肺炎双球菌、ストレプトコッカス・ニューモニエ

関

連鎖球菌

• first aid step1 2006 p.134,138

細菌学

• グラム陽性球菌
• 西洋槍(ランセット)型の双球菌
• α溶血性。ランスフィールド分類には分類されない
• オプトヒン感受性
• 自己融解 autolysis ←　培養しすぎに注意
• 中心部の陥凹した集落
• 莢膜多糖体を有する　←　抗食菌作用(C3bの付着に抵抗する)
• IgA proteaseを分泌
• 健常人の5-250%の気道に存在するが莢膜がない弱毒の株

感染症

• 肺炎球菌感染症

• 肺炎(大葉性肺炎)

• 慢性気道感染症の急性増悪

• 中耳炎、心内膜炎、関節炎、腹膜炎、軟部組織の炎症(SMB.248)
• 髄膜炎(化膿性髄膜炎)
• 敗血症：sickle cell anemia, splenectomy

易感染性宿主

• 2歳以下の乳幼児や老人で重症化しやすい
• 脾臓を受けた患者、急性骨髄性白血病、骨髄移植、HIV感染症で発症しやすい

most common cause of:

MOPS are Most OPtochin Sensitive

• meningitis 髄膜炎
• otitis media 中耳炎
• pneumonia 肺炎
• sinusitis 副鼻腔炎

診断

• 臨床像から疑い、胸部X線、喀痰のグラム染色、尿中抗原を行う。グラム染色と尿中抗原が陽性であれば特異的な治療を開始する。 (IRE.1010)
• (経験的治療の前に？)診断及び感受性検査のために喀痰培養、血液培養検査を行う。

参考

• 光顕像

• http://www.fujita-hu.ac.jp/~kimigaai/byouri/syourei/syourei21.htm
• http://www.kamimutsukawa.com/vaccine.html
• http://fp-the-ambiguous.blogspot.com/2008/02/blog-post.html

USMLE

• Q book p.192 29

「resistant」

　　[★]

• adj.

• 抵抗性の、耐性の、抵抗する

関

recalcitrance、refractory、resist、resistance、resistive、stand、tolerance、tolerant、withstand

　 　

「pneumoniae」

　　[★] Streptococcus pneumoniae、Klebsiella pneumoniae、Mycoplasma pneumoniae、Chlamydia pneumoniae、Chlamydophila pneumoniae