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English Journal

Savioli L.
The New England journal of medicine.N Engl J Med.2014 Feb 13;370(7):665-6. doi: 10.1056/NEJMe1312403.
PMID 24521114

Speich B1, Ame SM, Ali SM, Alles R, Huwyler J, Hattendorf J, Utzinger J, Albonico M, Keiser J.Author information 1From the Departments of Medical Parasitology and Infection Biology (B.S., J.K.) and Epidemiology and Public Health (J. Hattendorf, J.U.), Swiss Tropical and Public Health Institute, and the Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel (R.A., J. Huwyler) - all in Basel, Switzerland; the Laboratory Division, Public Health Laboratory-Ivo de Carneri, Chake Chake, Tanzania (S.M. Ame, S.M. Ali); and the Ivo de Carneri Foundation, Milan (M.A.).AbstractBACKGROUND: Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated with albendazole or mebendazole, but both drugs show low efficacy against T. trichiura. Albendazole is the drug of choice against hookworm.
The New England journal of medicine.N Engl J Med.2014 Feb 13;370(7):610-20. doi: 10.1056/NEJMoa1301956.
BACKGROUND: Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated with albendazole or mebendazole, but both drugs show low efficacy against T. trichiura.
PMID 24521107

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae.

Wimmersberger D1, Tritten L, Keiser J.Author information 1Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P,O, Box, Basel, CH-4002, Switzerland.AbstractBACKGROUND: Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are needed. To identify candidate compounds, in vitro drug sensitivity testing currently relies on the adult Trichuris muris motility assay. The objective of the present study was to develop a simple and cost-effective drug sensitivity assay using Trichuris muris first-stage larvae (L1).
Parasites & vectors.Parasit Vectors.2013 Feb 22;6:42. doi: 10.1186/1756-3305-6-42.
BACKGROUND: Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are needed. To identify candidate comp
PMID 23433224