- n.
WordNet
- an artifact that is one of the individual parts of which a composite entity is made up; especially a part that can be separated from or attached to a system; "spare components for cars"; "a component or constituent element of a system" (同)constituent, element
- an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a s (同)constituent, element, factor, ingredient
- a straight line that generates a cylinder or cone
- one of four substances thought in ancient and medieval cosmology to constitute the physical universe; "the alchemists believed that there were four elements"
- the situation in which you are happiest and most effective; "in your element"
- the most favorable environment for a plant or animal; "water is the element of fishes"
- a mixture of ingredients
- the spatial property resulting from the arrangement of parts in relation to each other and to the whole; "harmonious composition is essential in a serious work of art" (同)composing
- something that is created by arranging several things to form a unified whole; "he envied the composition of their faculty"
- an essay (especially one written as an assignment); "he got an A on his composition" (同)paper, report, theme
- constitutional in the structure of something (especially your physical makeup) (同)constitutional, constitutive, organic
- (grammar) a word or phrase or clause forming part of a larger grammatical construction (同)grammatical constituent
- a member of a constituency; a citizen who is represented in a government by officials for whom he or she votes; "needs continued support by constituents to be re-elected"
- one of two (approximately) equal parts (同)mediety
- one of two basic subdivisions of a tribe
- a component of a mixture or compound
- food that is a component of a mixture in cooking; "the recipe lists all the fixings for a salad" (同)fixings
PrepTutorEJDIC
- 構成している,成分の / 構成要素,成分
- 〈C〉(物質を構成する)元素 / 〈C〉《修飾語[句]を伴って》(…の)(基本的な)『要素』,『成分』;《しばしば複数形で》構成分子 / 〈C〉(生物に固有の)生息場所,環境;(人の)適所,本領 / 〈C〉《古》四大(しだい)[元素](自然界の基本的構成要素と考えられていた地(earth)・水(water)・風(air)・火(fire)の4大要素の一つ) / 《the elements》(雨・風・雪などの)自然力・風雨,(特に)悪天候 / 《the elements》(学問の)原理,初歩,概論
- 〈U〉(文学・美術・音楽作品などの)『創作』,制作[法];『作文』,『作曲』,〈C〉作品,楽曲 / 〈U〉(混合物などの)『成分』《+『of』+『名』》 / 〈C〉〈U〉(人の)気質,性質,性分(constitution) / 〈U〉(文学作品・音楽作品などの)構成,構想,(絵画などの)構図《+『of』+『名』》 / (またcompo)〈C〉混合物,合成物 / 〈U〉(活字の)植字,組み
- (またconstitutive)(ある物の)構成要素の / 選挙権(指名権)のある,憲法制定(改正)権のある / (ある物質の)成分,[構成]要素 / 選挙有権者,選挙人
- (法律用語で)(…の)半分《+『of』+『名』》
- (混合物の)成分,原料 / 構成要素
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/02 08:32:11」(JST)
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- 1. モノクローナル蛋白の認識 recognition of monoclonal proteins
- 2. 花粉関連、植物由来食物アレルギーに対するアレルゲンコンポーネント検査 component testing for pollen related plant derived food allergies
- 3. 緩和ケアの最新情報 whats new in palliative care
- 4. Complicated grief in adults: Treatment
- 5. 前立腺癌におけるMRIの役割 the role of magnetic resonance imaging in prostate cancer
English Journal
- A novel compound 6D-offset simulating phantom and quality assurance program for stereotactic image-guided radiation therapy system.
- Yuen Kan Ngar D, Lok-Man Cheung M, Koon-Ming Kam M, Poon WS, Tak-Cheung Chan A.Author information The Chinese University of Hong Kong. dykngar@hotmail.com.AbstractA comprehensive quality assurance (QA) device cum program was developed for the commissioning and routine testing of the 6D IGRT systems. In this article, both the new QA system and the BrainLAB IGRT system which was added onto a Varian Clinac were evaluated. A novel compound 6D-offset simulating phantom was designed and fabricated in the Prince of Wales Hospital (PWH), Hong Kong. The QA program generated random compound 6D-offset values. The 6D phantom was simply set up and shifted accordingly. The BrainLAB ExacTrac X-ray IGRT system detected the offsets and then corrected the phantom position automatically through the robotic couch. Routine QA works facilitated data analyses of the detection errors, the correction errors, and the correlations. Fifty sets of data acquired in 2011 in PWH were thoroughly analyzed. The 6D component detection errors and correction errors of the IGRT system were all within ± 1 mm and ± 1° individually. Translational and rotational scalar resultant errors were found to be 0.50 ± 0.27 mm and 0.54 ± 0.23°, respectively. Most individual component errors were shown to be independent of their original offset values. The system characteristics were locally established. The BrainLAB 6D IGRT system added onto a regular linac is sufficiently precise for stereotactic RT. This new QA methodology is competent to assure the IGRT system overall integrity. Annual grand analyses are recommended to check local system consistency and for external cross comparison. The target expansion policy of 1.5 mm 3D margin from CTV to PTV is confirmed for this IGRT system currently in PWH.
- Journal of applied clinical medical physics / American College of Medical Physics.J Appl Clin Med Phys.2014 Nov 4;14(6):4297. doi: 10.1120/jacmp.v14i6.4297.
- A comprehensive quality assurance (QA) device cum program was developed for the commissioning and routine testing of the 6D IGRT systems. In this article, both the new QA system and the BrainLAB IGRT system which was added onto a Varian Clinac were evaluated. A novel compound 6D-offset simulating ph
- PMID 24257294
- Novel Treatment of Acute Promyelocytic Leukemia: As2O3, Retinoic Acid and Retinoid Pharmacology.
- Zhu G, Mische SE, Seigneres B.Author information Institute of Oncology of George Zhu, 422407, Beijing, China. sansan4240732@163.com.AbstractAcute promyelocytic leukemia(APL), a specific characteristic of t(15;17) chromosome translocation, represents 5% to 15% of cases of acute nonlymphocytic leukemia. An alternative approach is to consider retinoic acid(all-trans RA, ATRA or 13-cis RA or 9-cis RA) plus chemotherapy or RA plus As2O3 regimens as now novel therapy. Molecular gene analyses are conclusive in vivo evidence that oncogenic PML/RARa plays a crucial role in APL leukemogenesis. As a novel approach to APL treatment, one possible the action of RA, A consense sequence (5'-TCAGGTCATGACCTGA-3') has been postulated for the thyroid hormone (TRE) and retinoic acid responsive element (RARE) containing half palindromes, which located in the promoter region of target genes. High dose (100-fold) of RA-RARE-PML/RARa complex in intracellular localization appears to relieve repressor from DNA binding, including corepressors N-CoR, SMRT and HDACs, release PML/RARa- mediated transcriptional repression, and release histone deacetylase activity from PMLRARa. The resulting PML/RARa oncoprotein proteolytic degradation through the autophagy-lysosome pathway and the ubiquitin SUMO-proteasome system (UPS), as well as caspase 3 (cleavage site Asp522 within a-helics region of PML component of the fusion protein) or neutrophil elastase, or lysosomal protease enzyme induction. PML protein relocalizes into the wild-type nuclear body (PML-NB) configuration or/and wild-type RARa upregulated. An effect to relieve the blockade (inhibition) of PML/RARA-mediated RA dependent promyelocytic differentiation, and retinoic acid in APL therapy (see Figure in the full text, George Zhu, 1991). Here, like v-erbA, PML/RARa is a (strong) transcriptional repressor of the RA receptor (RAR) complex, and PML/RARa fusion receptor gene act as conditional oncogenic receptor (translocated chimeric retinoic acid a signaling) or oncogenic PML/RARa may participate in leukemogenesis of APL through blocking RA-mediated promyelocytic differentiation. This is first described in eukaryotes.
- Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(9):849-58.
- Acute promyelocytic leukemia(APL), a specific characteristic of t(15;17) chromosome translocation, represents 5% to 15% of cases of acute nonlymphocytic leukemia. An alternative approach is to consider retinoic acid(all-trans RA, ATRA or 13-cis RA or 9-cis RA) plus chemotherapy or RA plus As2O3 regi
- PMID 24433507
- In vitro toxicity assessment of silver nanoparticles in the presence of phenolic compounds--preventive agents against the harmful effect?
- Martirosyan A, Bazes A, Schneider YJ.Author information Institute of Life Sciences & UCLouvain, Laboratory of Cellular, Nutritional and Toxicological Biochemistry , Louvain-la-Neuve , Belgium.AbstractThe increasing commercial use of silver nanoparticles (Ag-NPs) will inevitably lead to elevated silver exposure and thus to potential human health complications. In this study the acute toxicity of Ag-NPs <20 nm alone and upon co-administration with food matrix component phenolic compounds (PCs) on the cell-based models of the gastrointestinal tract was investigated. An improved co-culture model of Caco-2 and RajiB cells was applied for more precise in vitro simulation of the gastrointestinal tract. The involvement of two major factors contributing to the toxicity of Ag-NPs, i.e. the release of Ag(+) and the induction of oxidative stress, was investigated. Ag-NPs were cytotoxic for Caco-2 cells with an EC50 of ca. 40 µg/ml. Ag-NPs led to oxidative stress starting from ca. 45 µg/ml. The epithelial barrier integrity disruption by Ag-NPs on Caco-2 cell mono- and co-cultures was established by decreased transepithelial electrical resistances and increased passages of Lucifer Yellow, a paracellular marker. Immunofluorescence staining demonstrated that Ag-NPs affect occludin and zonula occludens 1 distributions, suggesting the opening of tight junctions. Ag(+), corresponding to the release from Ag-NPs, demonstrated a partial contribution in the toxic parameters, induced by Ag-NPs. Two PCs, quercetin and kaempferol, partially protected the Caco-2 cells from Ag-NP-induced toxicity and maintained the epithelial barrier integrity, disrupted by NPs. No protective effect was observed for resveratrol. The protective effect could be beneficial and decrease the potential toxicity of ingested Ag-NPs. However, the precise mechanisms of barrier-integrity-destabilising action of Ag-NPs/Ag(+) and protective effect of PCs still require further elucidation.
- Nanotoxicology.Nanotoxicology.2014 Aug;8(5):573-82. doi: 10.3109/17435390.2013.812258. Epub 2013 Jun 27.
- The increasing commercial use of silver nanoparticles (Ag-NPs) will inevitably lead to elevated silver exposure and thus to potential human health complications. In this study the acute toxicity of Ag-NPs <20 nm alone and upon co-administration with food matrix component phenolic compounds (PCs)
- PMID 23738887
- Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles.
- Wang XZ, Yang Y, Li R, McGuinnes C, Adamson J, Megson IL, Donaldson K.Author information Institute of Particle Science and Engineering, School of Process, Environmental and Materials Engineering, University of Leeds , Leeds LS2 9JT , UK.AbstractStructure toxicity relationship analysis was conducted using principal component analysis (PCA) for a panel of nanoparticles that included dry powders of oxides of titanium, zinc, cerium and silicon, dry powders of silvers, suspensions of polystyrene latex beads and dry particles of carbon black, nanotubes and fullerene, as well as diesel exhaust particles. Acute in vitro toxicity was assessed by different measures of cell viability, apoptosis and necrosis, haemolytic effects and the impact on cell morphology, while structural properties were characterised by particle size and size distribution, surface area, morphology, metal content, reactivity, free radical generation and zeta potential. Different acute toxicity measures were processed using PCA that classified the particles and identified four materials with an acute toxicity profile: zinc oxide, polystyrene latex amine, nanotubes and nickel oxide. PCA and contribution plot analysis then focused on identifying the structural properties that could determine the acute cytotoxicity of these four materials. It was found that metal content was an explanatory variable for acute toxicity associated with zinc oxide and nickel oxide, while high aspect ratio appeared the most important feature in nanotubes. Particle charge was considered as a determinant for high toxicity of polystyrene latex amine.
- Nanotoxicology.Nanotoxicology.2014 Aug;8(5):465-76. doi: 10.3109/17435390.2013.796534.
- Structure toxicity relationship analysis was conducted using principal component analysis (PCA) for a panel of nanoparticles that included dry powders of oxides of titanium, zinc, cerium and silicon, dry powders of silvers, suspensions of polystyrene latex beads and dry particles of carbon black, na
- PMID 23586395
Japanese Journal
- Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.
- Ohno Mikiko,Hiraoka Yoshinori,Lichtenthaler Stefan F,Nishi Kiyoto,Saijo Sayaka,Matsuoka Tatsuhiko,Tomimoto Hidekazu,Araki Wataru,Takahashi Ryosuke,Kita Toru,Kimura Takeshi,Nishi Eiichiro
- Neurobiology of aging 35(1), 213-222, 2014-01-00
- … Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. …
- NAID 120005347112
- Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets
- Ryoichi Kinoshita,Mitsuo Iwadate,Hideaki Umeyama,Y-H.Taguchi
- 情報処理学会研究報告. MPS, 数理モデル化と問題解決研究報告 2013-MPS-96(23), 1-6, 2013-12-04
- … Results: The recently proposed principal component analysis based selection of genes with aberrant DNA methylation was applied to genotype and DNA methylation patterns in squamous cell carcinoma measured using single nucleotide polymorphism (SNP) arrays. …
- NAID 110009634071
- グラフを用いたタンパク質のモーション表現法の提案
- 安富祖仁 ,峯田克彦 ,遠藤俊徳
- 情報処理学会研究報告. MPS, 数理モデル化と問題解決研究報告 2013-MPS-96(7), 1-7, 2013-12-04
- … 従来、トラジェクトリからのモーション抽出には主成分分析 (Principal Component Analysis, PCA) を利用した Essential Dynamics Analysis などの手法が用いられてきたが、線形手法に基づく方法ではタンパク質の非線形モーションの扱いが難しいという問題があった。 …
- NAID 110009634055
- Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets
- Ryoichi Kinoshita,Mitsuo Iwadate,Hideaki Umeyama,Y-H.Taguchi
- 情報処理学会研究報告. BIO, バイオ情報学 2013-BIO-36(23), 1-6, 2013-12-04
- … Results: The recently proposed principal component analysis based selection of genes with aberrant DNA methylation was applied to genotype and DNA methylation patterns in squamous cell carcinoma measured using single nucleotide polymorphism (SNP) arrays. …
- NAID 110009634045
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★リンクテーブル★
| リンク元 | 「element」「composition」「成分」「moiety」「constituent」 |
| 拡張検索 | 「multicomponent」「plant component」 |
「element」
- n.
- 要素、成分、素。(構成)分子。(科学)元素、(数)(集合の)要素、元素、素。(行列の)要素、成分。(図形を火ｔが千都来る)要素。(文法の)要素
- (電子)素子、(光学)素子
- 関
- basal、bases、basic、basis、component、composition、constituent、elementary、factor、fundamentals、ingredient、moiety
「composition」
- n.
- 関
- component、compose、comprise、constituent、constitute、constitution、construct、construction、constructional、context、element、formation、ingredient、moiety、organization、structure
「成分」
- n.
「moiety」
- n.
「constituent」
- n.
- 成分、(構成)要素。組成物、構成物。
「multicomponent」
- 多成分性の、多成分の