- 関
- LCAD、very-long-chain acyl-CoA dehydrogenase、VLCAD
WordNet
- primarily temporal sense; being or indicating a relatively great or greater than average duration or passage of time or a duration as specified; "a long life"; "a long boring speech"; "a long time"; "a long friendship"; "a long game"; "long ago"; "an hour long"
- (of speech sounds or syllables) of relatively long duration; "the English vowel sounds in `bate, `beat, `bite, `boat, `boot are long"
- for an extended distance
- for an extended time or at a distant time; "a promotion long overdue"; "something long hoped for"; "his name has long been forgotten"; "talked all night long"; "how long will you be gone?"; "arrived long before he was expected"; "it is long after your bedtime"
- having or being more than normal or necessary:"long on brains"; "in long supply"
- holding securities or commodities in expectation of a rise in prices; "is long on coffee"; "a long position in gold"
- involving substantial risk; "long odds"
- of relatively great height; "a race of long gaunt men"- Sherwood Anderson; "looked out the long French windows"
- primarily spatial sense; of relatively great or greater than average spatial extension or extension as specified; "a long road"; "a long distance"; "contained many long words"; "ten miles long"
- fasten or secure with chains; "Chain the chairs together"
- a unit of length
- a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
- a linked or connected series of objects; "a chain of daisies"
- a series of (usually metal) rings or links fitted into one another to make a flexible ligament
- anything that acts as a restraint
- (chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
- a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
- (business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
- connect or arrange into a chain by linking
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- prolonged unfulfilled desire or need (同)yearning, hungriness
- British biochemist (born in Germany) who isolated and purified penicillin, which had been discovered in 1928 by Sir Alexander Fleming (1906-1979) (同)Ernst Boris Chain, Sir Ernst Boris Chain
PrepTutorEJDIC
- (距離・物の長さが)『長い』 / (時間が)『長い』,長く続く / 《時間・距離などを表離などを表す語を伴って》長さが…の / 『長々しい』,あきあきする / (数量が標準よりも)『多い』,長い / (人が)やせてひょろ長い / 長く,長い間,久しく / …じゅう / ずっと(前に,後に) / 長い間
- 『熱望する』
- 『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
- carbonの化学記号
- 『あこがれ』,熱望 / (目の表情などが)あこがれの,熱望している
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/24 11:31:03」(JST)
[Wiki en表示]
Long-chain acyl-CoA dehydrogenase |
Identifiers |
EC number |
1.3.8.8 |
CAS number |
59536-74-2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
Long-chain acyl-CoA dehydrogenase (EC 1.3.8.8, palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, long-chain acyl-coenzyme A dehydrogenase, long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase, ACADL (gene).) is an enzyme with system name long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- a long-chain acyl-CoA + electron-transfer flavoprotein a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
This enzyme contains FAD as prosthetic group.
References
- ^ Crane, F.L., Hauge, J.G. and Beinert, H. (1955). "Flavoproteins involved in the first oxidative step of the fatty acid cycle". Biochim. Biophys. Acta 17: 292–294. doi:10.1016/0006-3002(55)90374-7. PMID 13239683.
- ^ Hauge, J.G., Crane, F.L. and Beinert, H. (1956). "On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl CoA dehydrogenase". J. Biol. Chem. 219: 727–733. PMID 13319294.
- ^ Hall, C.L., Heijkenkjold, L., Bartfai, T., Ernster, L. and Kamin, H. (1976). "Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef heart mitochondria". Arch. Biochem. Biophys. 177: 402–414. doi:10.1016/0003-9861(76)90453-7. PMID 1015826.
- ^ Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme". J. Biol. Chem. 260: 1311–1325. PMID 3968063.
- ^ Djordjevic, S., Dong, Y., Paschke, R., Frerman, F.E., Strauss, A.W. and Kim, J.J. (1994). "Identification of the catalytic base in long chain acyl-CoA dehydrogenase". Biochemistry 33: 4258–4264. doi:10.1021/bi00180a021. PMID 8155643.
External links
- Long-chain acyl-CoA dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Nickel inhibits mitochondrial fatty acid oxidation.
- Uppala R1, McKinney RW1, Brant KA2, Fabisiak JP2, Goetzman ES3.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Aug 7;463(4):806-10. doi: 10.1016/j.bbrc.2015.06.017. Epub 2015 Jun 5.
- Nickel exposure is associated with changes in cellular energy metabolism which may contribute to its carcinogenic properties. Here, we demonstrate that nickel strongly represses mitochondrial fatty acid oxidation-the pathway by which fatty acids are catabolized for energy-in both primary human lung
- PMID 26051273
- The production of ω-hydroxy palmitic acid using fatty acid metabolism and cofactor optimization in Escherichia coli.
- Sung C1, Jung E, Choi KY, Bae JH, Kim M, Kim J, Kim EJ, Kim PI, Kim BG.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2015 Aug;99(16):6667-76. doi: 10.1007/s00253-015-6630-1. Epub 2015 May 9.
- Hydroxylated fatty acids (HFAs) are used as important precursors for bulk and fine chemicals in the chemical industry. Here, to overproduce long-chain (C16-C18) fatty acids and hydroxy fatty acid, their biosynthetic pathways including thioesterase (Lreu_0335) from Lactobacillus reuteri DSM20016, β-
- PMID 25957153
- Gene Expression Patterns Associated with Peroxisome Proliferator-activated Receptor (PPAR) Signaling in the Longissimus dorsi of Hanwoo (Korean Cattle).
- Lim D1, Chai HH1, Lee SH1, Cho YM1, Choi JW1, Kim NK1.
- Asian-Australasian journal of animal sciences.Asian-Australas J Anim Sci.2015 Aug;28(8):1075-83. doi: 10.5713/ajas.14.0811.
- Adipose tissue deposited within muscle fibers, known as intramuscular fat (IMF or marbling), is a major determinant of meat quality and thereby affects its economic value. The biological mechanisms that determine IMF content are therefore of interest. In this study, 48 genes involved in the bovine p
- PMID 26104514
Japanese Journal
- 臨床研究・症例報告 反復する横紋筋融解症を契機に診断に至った極長鎖アシルCoA脱水素酵素欠損症の1例
- Effect of Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids on Hepatic Fatty Acid Oxidation after a Single Administration to Rats
- SHINOHARA Hisami,WU Jian,AOYAMA Toshiaki
- Bioscience, biotechnology, and biochemistry 74(11), 2336-2338, 2010-11-23
- … interesterified triacylglycerol containing medium- and long-chain fatty acids in the same glycerol molecule, showed significantly higher acyl-CoA dehydrogenase activity when measured by using butyryl-CoA, octanoyl-CoA, and palmitoyl-CoA as substrates than long-chain triacylglycerol one hour after a single …
- NAID 10027561946
Related Links
- Long-chain 3-hydroxy acyl-coenzyme A dehydrogenase (LCHAD) is 1 of 3 enzymatic activities that make up the trifunctional protein of the inner mitochondrial membrane. The other 2 activities of the protein are 2-enoyl ...
- Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is a condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting). Signs and symptoms of VLCAD ...
Related Pictures
★リンクテーブル★
[★]
- 英
- long-chain acyl-CoA dehydrogenase、LCAD
- 関
- 超長鎖アシルCoA脱水素酵素、極長鎖アシルCoA脱水素酵素
[★]
- 関
- long-chain acyl-CoA dehydrogenase、very-long-chain acyl-CoA dehydrogenase
[★]
- 関
- long-chain acyl-CoA dehydrogenase
[★]
- 関
- long-chain acyl-CoA dehydrogenase、VLCAD
- 同
- VLCAD
[★]
極長鎖アシルCoA脱水素酵素欠損症
[★]
長鎖アシルCoA脱水素酵素欠損症
[★]
[★]
- 関
- open-chain、strand
[★]
長い、望む
- 関
- desire、hope、lengthy、wish
[★]
[★]
脱水素酵素 デヒドロゲナーゼ