WordNet

with pain or distress or bitterness; "he took the rejection very hard"
(of light) transmitted directly from a pointed light source (同)concentrated
with firmness; "held hard to the railing" (同)firmly
very strong or vigorous; "strong winds"; "a hard left to the chin"; "a knockout punch"; "a severe blow" (同)knockout, severe
causing great damage or hardship; "industries hit hard by the depression"; "she was severely affected by the banks failure" (同)severely
being distilled rather than fermented; having a high alcoholic content; "hard liquor" (同)strong
unfortunate or hard to bear; "had hard luck"; "a tough break" (同)tough
(of speech sounds); produced with the back of the tongue raised toward or touching the velum; "Russian distinguished between hard consonants and palatalized or soft consonants"
dispassionate; "took a hard look"; "a hard bargainer";
dried out; "hard dry rolls left over from the day before"
earnestly or intently; "thought hard about it"; "stared hard at the accused"
into a solid condition; "concrete that sets hard within a few hours"
resisting weight or pressure
slowly and with difficulty; "prejudices die hard"
to the full extent possible; all the way; "hard alee"; "the ship went hard astern"; "swung the wheel hard left"
very near or close in space or time; "it stands hard by the railroad tracks"; "they were hard on his heels"; "a strike followed hard upon the plants opening"
with effort or force or vigor; "the team played hard"; "worked hard all day"; "pressed hard on the lever"; "hit the ball hard"; "slammed the door hard"
enclose in a capsule (同)capsulate, capsulize, capsulise
a dry dehiscent seed vessel or the spore-containing structure of e.g. mosses
a pill in the form of a small rounded gelatinous container with medicine inside
a small container
a structure that encloses a body part
a colorless water-soluble glutinous protein obtained from animal tissues such as bone and skin (同)gelatine
a thin translucent membrane used over stage lights for color effects (同)gel
an edible jelly (sweet or pungent) made with gelatin and used as a dessert or salad base or a coating for foods (同)jelly

PrepTutorEJDIC

(物体が)『堅い』,(手触りが)堅固な,しっかりした / 『難しい』,努力を要する / 《名詞の前にのみ用いて》(人が)『精力的な』,勤勉な / 激しい,猛烈な / (生活などが)耐え難い,つらい / (季節・天候などが)厳しい;(雨・風などが)激しい / (人が)厳格な;(行為などが)容赦しない,無情な / (方針・条件などが)妥協(譲歩)しない,厳しい / (感情が)うらみを含む,憤然とした / (体が)筋肉質の,がんじょうな / (紙幣に対して)硬貨の,(小切手などに対して)現金の;(貨幣が)容易に兌換(だかん)できる / (子音が)硬音の(c,gがcome, goのように[k],[g]と発音される) / アルコール分の多い / (水が)硬質の / (エックス線が)透過能力が大きい / 一生懸命に,『熱心に』 / 『強く』,激しく,大いに / やっと,かろうじて / 『堅く』 / ひどく悲んで / 接近して
小容器;(薬の)カプセル / (植物の)さく / (生物体の)被のう,被膜 / (宇宙ロケットの)カプセル / 小型の;簡約した
おや,はああ,ああ(驚き・喜び・疑い・ためらいなどを表す声)
hectare; hectares

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ワイヤレスカプセル内視鏡検査 wireless video capsule endoscopy
2. Elbow injuries in active children or skeletally immature adolescents: Approach
3. 予防接種に対するアレルギー反応 allergic reactions to vaccines
4. Overview of topical hemostatic agents and tissues adhesives used in surgery
5. 後天性上顎および硬口蓋欠損のマネージメント management of acquired maxillary and hard palate defects

English Journal

Effects of κ-carrageenan on rheological properties of dually modified sago starch: Towards finding gelatin alternative for hard capsules.

Fakharian MH1, Tamimi N1, Abbaspour H2, Mohammadi Nafchi A3, Karim AA4.
Carbohydrate polymers.Carbohydr Polym.2015 Nov 5;132:156-63. doi: 10.1016/j.carbpol.2015.06.033. Epub 2015 Jun 19.
Composite sago starch-based system was developed and characterized with the aim to find an alternative to gelatin in the processing of pharmaceutical capsules. Dually modified (Hydrolyzed-Hydroxypropylated) sago starches were combined with κ-carrageenan (0.25, 0.5, 0.75, and 1%). The rheological pr
PMID 26256336

The improvement of the dissolution rate of ziprasidone free base from solid oral formulations.

Zakowiecki D1, Cal K, Kaminski K, Adrjanowicz K, Swinder L, Kaminska E, Garbacz G.
AAPS PharmSciTech.AAPS PharmSciTech.2015 Aug;16(4):922-33. doi: 10.1208/s12249-015-0285-1. Epub 2015 Jan 16.
This work aims at increasing solubility and dissolution rate of ziprasidone free base-Biopharmaceutics Classifaction System (BCS) class II compound. The authors describe a practical approach to amorphization and highlight problems that may occur during the development of formulations containing amor
PMID 25588366

Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets.

Kan SL1, Lu J, Liu JP, Zhao Y.
Drug delivery.Drug Deliv.2015 Jul 21:1-8. [Epub ahead of print]
To reduce the drug plasma concentration fluctuation without being destroyed by gastric fluid, novel Esomeprazole magnesium modified-release pellets (EMZ-MRPs) with suitable in vitro release profiles and good in vitro and in vivo correlation (IVIVC) were developed. Fluid-bed was used to obtain EMZ-lo
PMID 24892629

Japanese Journal

新しい非ゼラチンハードカプセル

久保田浩敬,田久保貴久
薬剤学 = The archives of practical pharmacy 70(3), 198-201, 2010-05-01
NAID 10029100945

Advances in Mass Rearing of Chrysoperla carnea (Stephen) (Neuroptera: Chrysopidae)

Ashfaq Muhammad,Nasreen Abida,Cheema Ghulam Mustafa
南太平洋研究 24(2), 47-53, 2004
… In this technique hard gelatin capsules (500 mg) were used for larval rearing. … Sixty seven mg of frozen eggs of Sitotroga cereallela per larvawere offered in a single feed per capsule to complete its larval growth. …
NAID 120005232028

全自動錠剤分包機に関する基礎研究 : 幾何学的解析法による硬カプセルの大きさとフィーダー落下穴の寸法との関係

金井三良,近藤由利子,野呂俊一
病院薬学 11(1), 16-21, 1985-02-20
… The correlation between the size of commercial 1 capsules and that of drop holes of the capsule supply apparatus was studied by a geometric analysis on automatic tablet packaging machine (type OMP-CAT-150). …
NAID 110001798039