graft versus leukemia effect

移植片対白血病効果 GVL

WordNet

1. act so as to bring into existence; "effect a change"
2. a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"
3. (of a law) having legal validity; "the law is still in effect" (同)force
4. the central meaning or theme of a speech or literary work (同)essence, burden, core, gist
5. an impression (especially one that is artificial or contrived); "he just did it for effect"
6. produce; "The scientists set up a shock wave" (同)effectuate, set_up
7. cause to grow together parts from different plants; "graft the cherry tree branch onto the plum tree" (同)engraft, ingraft
8. the act of grafting something onto something else (同)grafting
9. (surgery) tissue or organ transplanted from a donor to a recipient; in some cases the patient can be both donor and recipient (同)transplant
10. malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
11. property of a personal character that is portable but not used in business; "she left some of her personal effects in the house"; "I watched over their effects until they returned" (同)personal_effects

PrepTutorEJDIC

1. 〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する
2. (つぎ木の)つぎ穂;つぎ木 / (皮被・内臓・骨などの)移植片 / (木に)〈つぎ穂〉‘を'つぐ,(体に)〈移植片〉‘を'移植する《+『名』+『on』(『upon』,『in』,『into』)+『名』》 / …‘を'結合させる《+『名』+『together』》 / (…に)つぎ木する,移植する《+『on』(『upon』,『in』,『into』)+『名』》
3. 収賄,汚職;贈賄;〈C〉汚職で得たもの / 汚職する,収賄する
4. (訴訟・競技などで)…対(《略》v.,vs.)(against) / (比較や二者択一において)…に対して
5. 白血病

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/27 11:43:21」(JST)

wiki en

[Wiki en表示]

Graft versus tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains donor T lymphocytes that are beneficial for recipient. Donor T-cells eliminate malignant residual host T-cells (graft versus leukemia) or eliminates diverse kinds of tumors. GvT might develop after recognizing tumor-specific or recipient-specific alloantigens.[99] It could lead to remission or immune control of hematologic malignancies. This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer. It is closely linked with graft versus host disease phenoma (GvHD). CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. The biology of GvT response still isn’t fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. This response is mediated largely by cytotoxic T lymphocytes (CTL) but it can be employed by natural killers (NK cells) as separate effectors, particularly in T-cell-depleted HLA-haploidentical HSCT.

See also

• Graft-versus-host disease
• Hematopoietic stem cell transplantation

References

UpToDate Contents

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• 1. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
• 2. 急性移植片対宿主病の予防 prevention of acute graft versus host disease
• 3. 成人における急性リンパ芽球性白血病に対する造血細胞移植の一般原則 general principles of hematopoietic cell transplantation for acute lymphoblastic leukemia in adults
• 4. 慢性リンパ性白血病における造血細胞移植 hematopoietic cell transplantation in chronic lymphocytic leukemia
• 5. 若年成人における急性骨髄性白血病に対する寛解後療法 post remission therapy for acute myeloid leukemia in younger adults

English Journal

• Comparison of outcomes after umbilical cord blood and unmanipulated haploidentical hematopoietic stem cell transplantation in children with high-risk acute lymphoblastic leukemia.

• Mo XD1,2, Tang BL3, Zhang XH1,2, Zheng CC3, Xu LP1,2, Zhu XY3, Wang Y1,2, Liu HL3, Yan CH1,2, Chu XD3, Chen H1,2, Geng LQ3, Liu KY1,2, Sun ZM3, Huang XJ1,2,4.
• International journal of cancer.Int J Cancer.2016 Nov 1;139(9):2106-15. doi: 10.1002/ijc.30249. Epub 2016 Jul 15.
• Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective therapy for children with high-risk acute lymphoblastic leukemia (ALL). Human leukocyte antigen (HLA)-haploidentical HSCT (haplo-HSCT) or umbilical cord blood transplantation (UCBT) are both important alternative sources of st
• PMID 27356906

• CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation.

• Lamers CH1, Wijers R1, van Bergen CA2, Somers JA3, Braakman E4, Gratama JW1, Debets R1, Falkenburg JH2, Cornelissen JJ4.
• Blood.Blood.2016 Oct 27;128(17):2165-2174. Epub 2016 Aug 16.
• Although double umbilical cord blood transplantation (dUCBT) in adult patients may be associated with less graft failure compared with single UCBT, hematopoietic recovery generally originates from a single cord blood unit (CBU). CBU predominance is still incompletely understood. We recently showed t
• PMID 27531680

• Allogeneic Stem Cell Transplantation: A Historical and Scientific Overview.

• Singh AK1, McGuirk JP2.
• Cancer research.Cancer Res.2016 Oct 26. [Epub ahead of print]
• The field of hematopoietic stem cell transplant (HSCT) has made ground-breaking progress in the treatment of many malignant and nonmalignant conditions. It has also pioneered the concepts of stem cell therapy and immunotherapy as a tool against cancer. The success of transplant for hematologic malig
• PMID 27784742

Japanese Journal

• 小児同種末梢血幹細胞移植後の間質性肺炎に合併した難治性気胸にEWSを用いた1例

• 気管支学 39(2), 150-153, 2017
• NAID 130005548779

• 造血幹細胞移植における幹細胞採取と移植成績

• Organ Biology 24(1), 61-69, 2017
• NAID 130005520108

• 同種移植におけるCAR-T細胞療法

• 日本造血細胞移植学会雑誌 6(1), 1-7, 2017
• NAID 130005292480

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拡張検索	「graft-versus-leukemia effect」
関連記事	「effect」「versus」「graft」「grafting」「effected」

「graft-versus-leukemia effect」

　　[★] 移植片対白血病効果

「effect」

　　[★]

• n.

• 結果。遂行、成就。
• 効果。効力。効き目、効能、影響。
• [美術・芸術]色彩、形の配合、光景、趣き、印象。外観、見え、体裁
• 趣旨、意図。本質、基本的意味

• vt.

• (変化などを)もたらす。(目的・計画など)果たす、遂げる。実施/施行する

関

act, action, affect, efficacy, impact, impinge, indication, influence, potency, effected

　 　 　 　 　 　 　

「versus」

　　[★]

(ラテン語versus(vertere(回す、向ける)のpp)、「～に向けられた→～の方向に、～に対して」)

• prep.

• (訴訟・競技などで)～対、～に対して(against)(v.,vs.)
• ～に対して、比較して

The first is the reliance on E-codes and ICD-9-CM codes for abuse to ascertain abusive versus accidental injuries.

関

pair、paired、pairwise、vs

　

「graft」

　　[★]

• n

• 移植片、グラフト

• v.

• 移植する、(植物)接木する

関

cell transplant、engraft、engraftment、explant、grafting、implant、implantation、organ graft、organ transplant、tissue graft、tissue transplant、transfer、transplant、transplant recipient、transplantation

　 　 　 　 　

「grafting」

　　[★]

• n.

• 移植、移植法、移植術

関

engraft、engraftment、graft、implant、implantation、transfer、transplant、transplantation

「effected」

　　[★]

• adj.

• 結果として生じる

関

effect