dynorphin A

ダイノルフィンA

dynorphin

WordNet

  1. the 1st letter of the Roman alphabet (同)a
  2. the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

  1. answer / ampere
  2. arsenicの化学記号

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/12 19:01:41」(JST)

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English Journal

  • Distinct physiological role of amidino-TAPA-sensitive and DAMGO-insensitive μ-opioid receptor splice variants in the mouse spinal cord.
  • Mizoguchi H, Watanabe C, Higashiya T, Takeda S, Moriyama K, Aoki Y, Kon-No T, Takagi H, Yonezawa A, Sato T, Sakurada T, Sakurada S.SourceDepartment of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
  • European journal of pharmacology.Eur J Pharmacol.2013 Apr 23. pii: S0014-2999(13)00307-5. doi: 10.1016/j.ejphar.2013.04.014. [Epub ahead of print]
  • The physiological role of the distinct splice variants for cloned mouse μ-opioid receptor (mMOR-1), mMOR-1J, mMOR-1K and mMOR-1L, which are sensitive to Nα-amidino-Tyr-d-Arg-Phe-β-Ala (amidino-TAPA) and insensitive to [d-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO), was described in the mouse spinal
  • PMID 23623932
  • The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors.
  • Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.SourceLaboratory of Alcoholism and Addictions Neuroscience, Department of Psychology (JLK, SS, DJR, BMW).
  • Biological psychiatry.Biol Psychiatry.2013 Apr 20. pii: S0006-3223(13)00267-9. doi: 10.1016/j.biopsych.2013.03.014. [Epub ahead of print]
  • BACKGROUND: The dynorphin (DYN)/kappa-opioid receptor (KOR) system undergoes neuroadaptations following chronic alcohol exposure that promote excessive operant self-administration and negative affective-like states; however, the exact mechanisms are unknown. The present studies tested the hypothesis
  • PMID 23611261
  • Nardilysin in human brain diseases: both friend and foe.
  • Bernstein HG, Stricker R, Dobrowolny H, Steiner J, Bogerts B, Trübner K, Reiser G.SourceDepartment of Psychiatry, Otto-v.-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany, Hans-Gert.Bernstein@med.ovgu.de.
  • Amino acids.Amino Acids.2013 Apr 19. [Epub ahead of print]
  • Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, α-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties. It has various functionally important molecular interaction partners (heparin-binding epidermal growth factor-like growth
  • PMID 23604405

Japanese Journal

  • Dynorphin A (1-13) Alleviated Stress-Induced Behavioral Impairments in Mice
  • Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
  • Biological & pharmaceutical bulletin 37(8), 1269-1273, 2014-08
  • NAID 40020136554
  • ストレス関連行動変化における内因性κ-オピオイドシステムの役割 : マウス学習性無力試験を用いた行動学的・神経化学的解析
  • 間宮 隆吉
  • 名城大学総合研究所総合学術研究論文集 (13), 11-17, 2014
  • NAID 40020207536
  • Dynorphin A (1–13) Alleviated Stress-Induced Behavioral Impairments in Mice
  • Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
  • Biological and Pharmaceutical Bulletin 37(8), 1269-1273, 2014
  • … In this study we investigated whether κ-opioid receptor stimulation by dynorphin A (1–13), a potent fragment of endogenous peptide, attenuated repeated stress-induced behavioral impairments in mice. … In order to reduce the motivation to escape, mice were preexposed to inescapable electric footshock (day 0), and then dynorphin A (1–13) was administered to mice prior to the stress from the next day for 4 d (days 1–4). …
  • NAID 130004677531

Related Links

Peptides , Dynorphin Peptides , Dynorphin A (1-17); YGGFLRRIRPKLKWDNQ; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH ... Product Name Dynorphin A (1 - 17) YGGFLRRIRPKLKWDNQ Size 5 mg
View and buy high purity Dynorphin A from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... References Dhawan et al (1996) International union of pharmacology XII. Classification of opioid ...


Related Pictures

Dynorphin A [ 1 ]Dynorphin A (1-13) Acetate | Buy Dynorphin  and dynorphin A, to the same scale; dynorphin; dynorphin a; dynorphin Dynorphin A (1-13) | 72957-38-1Dynorphin A(1-7)



★リンクテーブル★
リンク元オピオイド」「ダイノルフィンA
関連記事A」「Ad

オピオイド」

  [★]

opioid
類麻薬
オピオイド受容体


作用

縮瞳

  • モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)

オピオイドとオピオイド類似物質の作用

GOO.552
Drugs  RECEPTOR TYPES
μ受容体 δ受容体 κ受容体
morphine +++  
methadone +++    
etorphine +++ +++ +++
levorphanol +++    
fentanyl +++    
sufentanil +++
DAMGO +++    
butorphanol P   +++
buprenorphine P   ーー
naloxone ーーー ーー
naltrexone ーーー ーーー
CTOP ーーー    
diprenorphine ーーー ーー ーーー
β-funaltrexamine ーーー ++
naloxonazine ーーー
nalorphine ーーー  
pentazocine P   ++
nalbuphine ーー   ++
naloxone benzoylhydrazone ーーー
bremazocine +++ ++ +++
ethylketocyclazocine P +++
U50,488     +++
U69,593     +++
spiradoline   +++
nor-Binaltorphimine ーーー
naltrindole ーーー
DPDPE   ++  
[[[[D-Ala2,Glu4]deltorphin]]   ++  
       
DSLET ++  
endogenous Peptides      
met-enkephalin ++ +++  
leu-enkephalin ++ +++  
β-endorphin +++ +++  
dynorphin A ++   +++
dynorphin B +++
α-neoendorphin +++
+アゴニスト ーアンタゴニスト P partial agonist

各鎮痛薬のオピオイド受容体への作用

         μ受容体 κ受容体
レミフェンタニル +++  ー
フェンタニル   +++  -
モルヒネ     +++  +
ペチジン     ++   +
トラマドール   +    -
ペンタゾシン   ー    ++
ブプレノルフィン P    ー
ナロキソン    ー    -

ダイノルフィンA」

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dynorphin A
ダイノルフィン

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