dynorphin A




  1. the 1st letter of the Roman alphabet (同)a
  2. the blood group whose red cells carry the A antigen (同)type_A, group A


  1. answer / ampere
  2. arsenicの化学記号

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/12 19:01:41」(JST)

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English Journal

  • Distinct physiological role of amidino-TAPA-sensitive and DAMGO-insensitive μ-opioid receptor splice variants in the mouse spinal cord.
  • Mizoguchi H, Watanabe C, Higashiya T, Takeda S, Moriyama K, Aoki Y, Kon-No T, Takagi H, Yonezawa A, Sato T, Sakurada T, Sakurada S.SourceDepartment of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
  • European journal of pharmacology.Eur J Pharmacol.2013 Apr 23. pii: S0014-2999(13)00307-5. doi: 10.1016/j.ejphar.2013.04.014. [Epub ahead of print]
  • The physiological role of the distinct splice variants for cloned mouse μ-opioid receptor (mMOR-1), mMOR-1J, mMOR-1K and mMOR-1L, which are sensitive to Nα-amidino-Tyr-d-Arg-Phe-β-Ala (amidino-TAPA) and insensitive to [d-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO), was described in the mouse spinal
  • PMID 23623932
  • The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors.
  • Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.SourceLaboratory of Alcoholism and Addictions Neuroscience, Department of Psychology (JLK, SS, DJR, BMW).
  • Biological psychiatry.Biol Psychiatry.2013 Apr 20. pii: S0006-3223(13)00267-9. doi: 10.1016/j.biopsych.2013.03.014. [Epub ahead of print]
  • BACKGROUND: The dynorphin (DYN)/kappa-opioid receptor (KOR) system undergoes neuroadaptations following chronic alcohol exposure that promote excessive operant self-administration and negative affective-like states; however, the exact mechanisms are unknown. The present studies tested the hypothesis
  • PMID 23611261
  • Nardilysin in human brain diseases: both friend and foe.
  • Bernstein HG, Stricker R, Dobrowolny H, Steiner J, Bogerts B, Trübner K, Reiser G.SourceDepartment of Psychiatry, Otto-v.-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany, Hans-Gert.Bernstein@med.ovgu.de.
  • Amino acids.Amino Acids.2013 Apr 19. [Epub ahead of print]
  • Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, α-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties. It has various functionally important molecular interaction partners (heparin-binding epidermal growth factor-like growth
  • PMID 23604405

Japanese Journal

  • Dynorphin A (1-13) Alleviated Stress-Induced Behavioral Impairments in Mice
  • Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
  • Biological & pharmaceutical bulletin 37(8), 1269-1273, 2014-08
  • NAID 40020136554
  • ストレス関連行動変化における内因性κ-オピオイドシステムの役割 : マウス学習性無力試験を用いた行動学的・神経化学的解析
  • 間宮 隆吉
  • 名城大学総合研究所総合学術研究論文集 (13), 11-17, 2014
  • NAID 40020207536
  • Dynorphin A (1–13) Alleviated Stress-Induced Behavioral Impairments in Mice
  • Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
  • Biological and Pharmaceutical Bulletin 37(8), 1269-1273, 2014
  • … In this study we investigated whether κ-opioid receptor stimulation by dynorphin A (1–13), a potent fragment of endogenous peptide, attenuated repeated stress-induced behavioral impairments in mice. … In order to reduce the motivation to escape, mice were preexposed to inescapable electric footshock (day 0), and then dynorphin A (1–13) was administered to mice prior to the stress from the next day for 4 d (days 1–4). …
  • NAID 130004677531

Related Links

Peptides , Dynorphin Peptides , Dynorphin A (1-17); YGGFLRRIRPKLKWDNQ; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH ... Product Name Dynorphin A (1 - 17) YGGFLRRIRPKLKWDNQ Size 5 mg
View and buy high purity Dynorphin A from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... References Dhawan et al (1996) International union of pharmacology XII. Classification of opioid ...

Related Pictures

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  • モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)


μ受容体 δ受容体 κ受容体
morphine +++  
methadone +++    
etorphine +++ +++ +++
levorphanol +++    
fentanyl +++    
sufentanil +++
DAMGO +++    
butorphanol P   +++
buprenorphine P   ーー
naloxone ーーー ーー
naltrexone ーーー ーーー
CTOP ーーー    
diprenorphine ーーー ーー ーーー
β-funaltrexamine ーーー ++
naloxonazine ーーー
nalorphine ーーー  
pentazocine P   ++
nalbuphine ーー   ++
naloxone benzoylhydrazone ーーー
bremazocine +++ ++ +++
ethylketocyclazocine P +++
U50,488     +++
U69,593     +++
spiradoline   +++
nor-Binaltorphimine ーーー
naltrindole ーーー
DPDPE   ++  
[[[[D-Ala2,Glu4]deltorphin]]   ++  
DSLET ++  
endogenous Peptides      
met-enkephalin ++ +++  
leu-enkephalin ++ +++  
β-endorphin +++ +++  
dynorphin A ++   +++
dynorphin B +++
α-neoendorphin +++
+アゴニスト ーアンタゴニスト P partial agonist


         μ受容体 κ受容体
レミフェンタニル +++  ー
フェンタニル   +++  -
モルヒネ     +++  +
ペチジン     ++   +
トラマドール   +    -
ペンタゾシン   ー    ++
ブプレノルフィン P    ー
ナロキソン    ー    -



dynorphin A