関: dynorphin

WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

answer / ampere
arsenicの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/12 19:01:41」(JST)

wiki en

Dynorphin A is a form of dynorphin and an endogenous opioid peptide with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.

References

^ Dynorphin 1-13 - Compound Summary, PubChem.

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UpToDate Contents

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1. 慢性疼痛の定義および病因 definition and pathogenesis of chronic pain
2. 成人における急性オピオイド中毒 acute opioid intoxication in adults
3. 性腺刺激ホルモン（ゴナドトロピン）放出ホルモンの生理学 physiology of gonadotropin releasing hormone
4. コルチコトロピン-放出ホルモン（CRH）の生理学 physiology of corticotropin releasing hormone
5. 尿毒症性そう痒症 uremic pruritus

English Journal

Distinct physiological role of amidino-TAPA-sensitive and DAMGO-insensitive μ-opioid receptor splice variants in the mouse spinal cord.

Mizoguchi H, Watanabe C, Higashiya T, Takeda S, Moriyama K, Aoki Y, Kon-No T, Takagi H, Yonezawa A, Sato T, Sakurada T, Sakurada S.SourceDepartment of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
European journal of pharmacology.Eur J Pharmacol.2013 Apr 23. pii: S0014-2999(13)00307-5. doi: 10.1016/j.ejphar.2013.04.014. [Epub ahead of print]
The physiological role of the distinct splice variants for cloned mouse μ-opioid receptor (mMOR-1), mMOR-1J, mMOR-1K and mMOR-1L, which are sensitive to Nα-amidino-Tyr-d-Arg-Phe-β-Ala (amidino-TAPA) and insensitive to [d-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO), was described in the mouse spinal
PMID 23623932

The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors.

Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.SourceLaboratory of Alcoholism and Addictions Neuroscience, Department of Psychology (JLK, SS, DJR, BMW).
Biological psychiatry.Biol Psychiatry.2013 Apr 20. pii: S0006-3223(13)00267-9. doi: 10.1016/j.biopsych.2013.03.014. [Epub ahead of print]
BACKGROUND: The dynorphin (DYN)/kappa-opioid receptor (KOR) system undergoes neuroadaptations following chronic alcohol exposure that promote excessive operant self-administration and negative affective-like states; however, the exact mechanisms are unknown. The present studies tested the hypothesis
PMID 23611261

Nardilysin in human brain diseases: both friend and foe.

Bernstein HG, Stricker R, Dobrowolny H, Steiner J, Bogerts B, Trübner K, Reiser G.SourceDepartment of Psychiatry, Otto-v.-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany, Hans-Gert.Bernstein@med.ovgu.de.
Amino acids.Amino Acids.2013 Apr 19. [Epub ahead of print]
Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, α-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties. It has various functionally important molecular interaction partners (heparin-binding epidermal growth factor-like growth
PMID 23604405

Japanese Journal

Dynorphin A (1-13) Alleviated Stress-Induced Behavioral Impairments in Mice

Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
Biological & pharmaceutical bulletin 37(8), 1269-1273, 2014-08
NAID 40020136554

ストレス関連行動変化における内因性κ-オピオイドシステムの役割 : マウス学習性無力試験を用いた行動学的・神経化学的解析

間宮隆吉
名城大学総合研究所総合学術研究論文集 (13), 11-17, 2014
NAID 40020207536

Dynorphin A (1–13) Alleviated Stress-Induced Behavioral Impairments in Mice

Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
Biological and Pharmaceutical Bulletin 37(8), 1269-1273, 2014
… In this study we investigated whether κ-opioid receptor stimulation by dynorphin A (1–13), a potent fragment of endogenous peptide, attenuated repeated stress-induced behavioral impairments in mice. … In order to reduce the motivation to escape, mice were preexposed to inescapable electric footshock (day 0), and then dynorphin A (1–13) was administered to mice prior to the stress from the next day for 4 d (days 1–4). …
NAID 130004677531

「オピオイド」

Dynorphin A^[1]
Names
	Other names Dynorphin 1-13
Identifiers
CAS Registry Number	72957-38-1
PubChem	16130969
Properties
Chemical formula	C75H126N24O15
Molar mass	1603.95474
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is: /?)
	Infobox references

　　[★]

英: opioid
同: 類麻薬
関: オピオイド受容体

オピオイド受容体に結合するモルフィン様物質のことを指す。

内因性のオピオイドペプチドが発見され、これらは内因性オピオイドペプチドと呼ばれるようになった。

作用

縮瞳

モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)

オピオイドとオピオイド類似物質の作用

GOO.552

Drugs	RECEPTOR TYPES
Drugs	μ受容体	δ受容体	κ受容体
morphine	＋＋＋		＋
methadone	＋＋＋
etorphine	＋＋＋	＋＋＋	＋＋＋
levorphanol	＋＋＋
fentanyl	＋＋＋
sufentanil	＋＋＋	＋	＋
DAMGO	＋＋＋
butorphanol	P		＋＋＋
buprenorphine	P		ーー
naloxone	ーーー	ー	ーー
naltrexone	ーーー	ー	ーーー
CTOP	ーーー
diprenorphine	ーーー	ーー	ーーー
β-funaltrexamine	ーーー	ー	＋＋
naloxonazine	ーーー	ー	ー
nalorphine	ーーー		＋
pentazocine	P		＋＋
nalbuphine	ーー		＋＋
naloxone benzoylhydrazone	ーーー	ー	ー
bremazocine	＋＋＋	＋＋	＋＋＋
ethylketocyclazocine	P	＋	＋＋＋
U50,488			＋＋＋
U69,593			＋＋＋
spiradoline	＋		＋＋＋
nor-Binaltorphimine	ー	ー	ーーー
naltrindole	ー	ーーー	ー
DPDPE		＋＋
[[［[D-Ala2,Glu4］deltorphin]]		＋＋

DSLET	＋	＋＋
endogenous Peptides
met-enkephalin	＋＋	＋＋＋
leu-enkephalin	＋＋	＋＋＋
β-endorphin	＋＋＋	＋＋＋
dynorphin A	＋＋		＋＋＋
dynorphin B	＋	＋	＋＋＋
α-neoendorphin	＋	＋	＋＋＋

＋アゴニスト　ーアンタゴニスト　P partial agonist

各鎮痛薬のオピオイド受容体への作用

　　　　　　　　　μ受容体　κ受容体

レミフェンタニル　＋＋＋　　ー

フェンタニル　　　＋＋＋　　－

モルヒネ　　　　　＋＋＋　　＋

ペチジン　　　　　＋＋　　　＋

トラマドール　　　＋　　　　－

ペンタゾシン　　　ー　　　　＋＋

ブプレノルフィン　Ｐ　　　　ー

ナロキソン　　　　ー　　　　－

「ダイノルフィンA」

　　[★]

英: dynorphin A
関: ダイノルフィン

「A」

　　[★]

「Ad」

　　[★]

アデノウイルス

関: adenoviral、adenovirus

[1] Dynorphin 1-13 - Compound Summary, PubChem.

リンク元	「オピオイド」「ダイノルフィンA」
関連記事	「A」「Ad」

匿名

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案内

案内

dynorphin A