WordNet
- a potent narcotic antagonist (trade name Narcan) especially effective with morphine (同)Narcan
UpToDate Contents
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English Journal
- Binding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor.
- McDonald J1, Lambert DG.
- British journal of pharmacology.Br J Pharmacol.2010 Mar;159(6):1286-93. doi: 10.1111/j.1476-5381.2009.00621.x. Epub 2010 Feb 10.
- BACKGROUND AND PURPOSE: We have examined the effects of ligand efficacy and receptor density on the binding of guanosine 5'-[gamma-thio]triphosphate (GTPgammaS) and GDP to the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-coupled G-proteins. Experimental approach: In GTPgamma[(35)S] binding
- PMID 20148892
- The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis.
- Kuzmin A1, Madjid N, Johansson B, Terenius L, Ogren SO.
- Brain research.Brain Res.2009 Dec 11;1305 Suppl:S7-19. doi: 10.1016/j.brainres.2009.09.075. Epub 2009 Sep 25.
- This study examines the effects of NOP agonists nociceptin/orphanin FQ (N/OFQ) and Ro 64-6198, NOP antagonists [Nphe(1)]N/OFQ(1-13)-NH(2) Nphe(1) and naloxone benzoylhydrazone (NalBzoH) on spatial memory in NMRI mice and pronociceptin (proNC) knockout (KO) mice using the water maze task. N/OFQ, admi
- PMID 19782658
Japanese Journal
- Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats
- , , [他], ,
- The Japanese journal of pharmacology 87(1), 14-20, 2001-09-01
- … The LV injection of naloxone benzoylhydrazone (a κ3-opioid receptor agonist, 100 μg) also stimulated the secretion in norbinaltorphimine-sensitive manner. …
- NAID 130000078334
- Characterization of Specific[^3H]Nociceptin Binding in Rat Brain and Spinal Cord
- , ,
- Biological & pharmaceutical bulletin 24(8), 902-905, 2001-08-01
- … Nociceptin and its analogue, [Phe^1Ψ(CH_2-NH)-Gly^2]nociceptin(1-13)NH_2 were found to be potent inhibitors of[^3H]nociceptin binding to crude membranes from the brain and spinal cord, while opioid ligands such as naloxone-benzoylhydrazone, naltrindole and nor-binaltorphimine, exhibited an inhibitory effect only at high concentrations. …
- NAID 110003638585
Related Links
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★リンクテーブル★
[★]
- 英
- opioid
- 同
- 類麻薬
- 関
- オピオイド受容体
作用
縮瞳
- モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)
オピオイドとオピオイド類似物質の作用
- GOO.552
＋アゴニスト ーアンタゴニスト P partial agonist
各鎮痛薬のオピオイド受容体への作用
- μ受容体 κ受容体
- レミフェンタニル ＋＋＋ ー
- フェンタニル ＋＋＋ －
- モルヒネ ＋＋＋ ＋
- ペチジン ＋＋ ＋
- トラマドール ＋ －
- ペンタゾシン ー ＋＋
- ブプレノルフィン Ｐ ー
- ナロキソン ー －