1. an oral antagonist against the action of opiates

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/22 15:39:50」(JST)

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English Journal

  • An evaluation of hepatic enzyme elevations among HIV-infected released prisoners enrolled in two randomized placebo-controlled trials of extended release naltrexone.
  • Vagenas P1, Di Paola A1, Herme M1, Lincoln T2, Skiest DJ2, Altice FL3, Springer SA4.
  • Journal of substance abuse treatment.J Subst Abuse Treat.2014 Jul;47(1):35-40. doi: 10.1016/j.jsat.2014.02.008. Epub 2014 Mar 12.
  • Extended-release naltrexone (XR-NTX), an approved treatment for opioid or alcohol dependence, is a once-monthly injectable formulation of naltrexone. Hepatotoxicity concerns have limited its use, necessitating further investigation. This study aims to examine hepatic enzyme levels in participants of
  • PMID 24674234
  • Naltrexone-loaded poly[La-(Glc-Leu)] polymeric microspheres for the treatment of alcohol dependence: in vitro characterization and in vivo biocompatibility assessment.
  • Pagar KP1, Vavia PR.
  • Pharmaceutical development and technology.Pharm Dev Technol.2014 Jun;19(4):385-94. doi: 10.3109/10837450.2013.784334. Epub 2013 Apr 16.
  • The poly[La-(Glc-Leu)] copolymer was applied in the present investigation as polymeric carrier to fabricate naltrexone (NTX)-loaded poly[La-(Glc-Leu)] microspheres in the single emulsion solvent evaporation technique for the long-term treatment of alcohol dependence. Newly synthesized poly[La-(Glc-L
  • PMID 23590187
  • Ex vivo studies for the passive transdermal delivery of low-dose naltrexone from a cream; detection of naltrexone and its active metabolite, 6β-naltrexol, using a novel LC Q-ToF MS assay.
  • Dodou K1, Armstrong A, Kelly I, Wilkinson S, Carr K, Shattock P, Whiteley P.
  • Pharmaceutical development and technology.Pharm Dev Technol.2014 May 2. [Epub ahead of print]
  • Abstract Naltrexone (NTX) is a long-acting opiate antagonist. Low-dose naltrexone (LDN) therapy has shown promising results in the treatment of several autoimmune disorders. Our aim was to formulate NTX into a cream for the delivery of LDN and develop an analytical technique for the quantification o
  • PMID 24785567

Japanese Journal

  • アルコール依存症の治療--薬物療法を中心として (特集 アルコール依存症の展開)
  • 松下 幸生
  • 日本精神科病院協会雑誌 30(4), 329-334, 2011-04-00
  • NAID 40018810809
  • Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice
  • Tsukumo Yukihito,Harada Daisuke,Manabe Haruhiko
  • Journal of pharmacological sciences 113(3), 255-262, 2010-07-20
  • … Both severe and continuous scratching behaviors were suppressed by the opioid-receptor antagonist naltrexone, but not by the H<SUB>1</SUB> …
  • NAID 10029889358
  • Scratching Behavior of ICR-Derived Glomerulonephritis (ICGN) Mice
  • Miyamoto Yohei,Umeuchi Hideo,Kurokawa Takahiro [他],NAKAO Kaoru,OKANO Kiyoshi
  • 日本獣醫學会会誌 72(9), 1243-1245, 2010
  • … Furthermore, the scratching may have reflected a pruritus associated with renal dysfunction because it was inhibited by an opioid antagonist, naltrexone (3 mg/kg), effective against pruritus in hemodialysis patients. …
  • NAID 130000264228

Related Links

Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade ...
【ナルトレキソン(Naltrexone)とは】. ナルトレソンはモルヒネに似た構造の化合物で、 モルヒネなどのオピオイドイドとオピオイド受容体の結合を阻害する薬です。 麻薬中毒や アルコール中毒など薬物依存症の治療に使用されています。依存症の治療に使う量の 10 ...

Related Pictures

NaltrexoneNaltrexone skeletal.svg KRS Global Biotech on Low Dose NaltrexoneRevolucionária terapia LDN para Esclerose Lose Dose Naltrexone (LDN) – Wonder Drug Naltrexone Use

拡張検索naltrexone hydrochloride






  • モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)


μ受容体 δ受容体 κ受容体
morphine +++  
methadone +++    
etorphine +++ +++ +++
levorphanol +++    
fentanyl +++    
sufentanil +++
DAMGO +++    
butorphanol P   +++
buprenorphine P   ーー
naloxone ーーー ーー
naltrexone ーーー ーーー
CTOP ーーー    
diprenorphine ーーー ーー ーーー
β-funaltrexamine ーーー ++
naloxonazine ーーー
nalorphine ーーー  
pentazocine P   ++
nalbuphine ーー   ++
naloxone benzoylhydrazone ーーー
bremazocine +++ ++ +++
ethylketocyclazocine P +++
U50,488     +++
U69,593     +++
spiradoline   +++
nor-Binaltorphimine ーーー
naltrindole ーーー
DPDPE   ++  
[[[[D-Ala2,Glu4]deltorphin]]   ++  
DSLET ++  
endogenous Peptides      
met-enkephalin ++ +++  
leu-enkephalin ++ +++  
β-endorphin +++ +++  
dynorphin A ++   +++
dynorphin B +++
α-neoendorphin +++
+アゴニスト ーアンタゴニスト P partial agonist


         μ受容体 κ受容体
レミフェンタニル +++  ー
フェンタニル   +++  -
モルヒネ     +++  +
ペチジン     ++   +
トラマドール   +    -
ペンタゾシン   ー    ++
ブプレノルフィン P    ー
ナロキソン    ー    -



塩酸ナルトレキソン naltrexone hydrochloride
  • オピオイド受容体拮抗薬
  • 日本での販売はない。




naltrexone hydrochloride」