WordNet
- the basic unit of money in Moldova
- the basic unit of money in Romania
- an endorphin having opiate qualities that occurs in the brain and spinal cord and elsewhere
PrepTutorEJDIC
- レウ(ルーマニアの貨幣単位)
- liter[s]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/28 08:50:40」(JST)
[Wiki en表示]
Leu-enkephalin |
|
IUPAC name
(2R)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3-
(4-hydroxyphenyl)propanoyl]amino]acetyl]
amino]acetyl]amino]-3-phenylpropanoyl]
amino]-4-methylpentanoic acid
|
Identifiers |
CAS number |
58822-25-6 Y |
PubChem |
461776 |
ChemSpider |
406229 N |
ChEMBL |
CHEMBL8234 N |
IUPHAR ligand |
1613 |
Jmol-3D images |
Image 1 |
-
O=C(O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)Cc2ccccc2)CC(C)C
|
-
InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1 N
Key: URLZCHNOLZSCCA-VABKMULXSA-N N
InChI=1/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1
Key: URLZCHNOLZSCCA-VABKMULXBR
|
Properties |
Molecular formula |
C28H37N5O7 |
Molar mass |
555.62268 g/mol |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
N (verify) (what is: Y/N?) |
Infobox references |
|
|
Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine. Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.
See also
References
|
This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (November 2011) |
Peptides: neuropeptides
|
|
Hormones |
see hormones
|
|
Opioid peptides |
Dynorphins
|
- Big dynorphin
- Dynorphin A
- Dynorphin B
- Leumorphin
|
|
Endomorphins
|
- Endomorphin-1
- Endomorphin-2
|
|
Endorphins
|
- α-Endorphin
- β-Endorphin
- γ-Endorphin
- α-Neoendorphin
- β-Neoendorphin
|
|
Enkephalins
|
- Met-enkephalin
- Leu-enkephalin
|
|
Others
|
- Adrenorphin
- Amidorphin
- Nociceptin
- Opiorphin
- Spinorphin
|
|
|
Other
neuropeptides |
Kinins
|
- Tachykinins: mammal
- Substance P
- Neurokinin A
- Neurokinin B
- amphibian
|
|
Neuromedins
|
|
|
Other
|
- Angiotensin
- Bombesin
- Calcitonin gene-related peptide
- Carnosine
- Cocaine and amphetamine regulated transcript
- Delta sleep-inducing peptide
- FMRFamide
- Galanin
- Galanin-like peptide
- Gastrin releasing peptide
- Ghrelin
- Neuropeptide S
- Neuropeptide Y
- Neurophysins
- Neurotensin
- Pancreatic polypeptide
- Pituitary adenylate cyclase activating peptide
- RVD-Hpα
- VGF
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
Opioidergics
|
|
Receptor |
|
|
Enzyme
(inhibitors) |
Enkephalinase
|
- BL-2401
- Candoxatril
- D-Phenylalanine
- Ecadotril
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Bioactivity studies on atypical natural opioid hexapeptides processed from proenkephalin (PENK) precursor polypeptides.
- Bojnik E1, Kleczkowska P2, de Velasco EM3, Corbani M4, Babos F5, Lipkowski AW2, Magyar A5, Benyhe S6.
- Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.Comp Biochem Physiol B Biochem Mol Biol.2014 Aug;174:29-35. doi: 10.1016/j.cbpb.2014.06.002. Epub 2014 Jun 16.
- Endogenous opioids are derived from four related polypeptide precursors: proenkephalin (PENK), prodynorphin (PDYN), pronociceptin (PNOC) and proopiomelanocortin (POMC). In mammals PENK encodes for four copy of Met-enkephalin, one octapeptide Met-enkephalin-Arg-Gly-Leu, one heptapeptide Met-enkephali
- PMID 24947211
- Direct Identification of Tyrosine Sulfation by using Ultraviolet Photodissociation Mass Spectrometry.
- Robinson MR1, Moore KL, Brodbelt JS.
- Journal of the American Society for Mass Spectrometry.J Am Soc Mass Spectrom.2014 Aug;25(8):1461-71. doi: 10.1007/s13361-014-0910-3. Epub 2014 May 21.
- Sulfation is a common post-translational modification of tyrosine residues in eukaryotes; however, detection using traditional liquid chromatography-mass spectrometry (LC-MS) methods is challenging based on poor ionization efficiency in the positive ion mode and facile neutral loss upon collisional
- PMID 24845354
Japanese Journal
- 高次元アルゴリズム (HA : Hamiltonian Algorithm) を用いた Enkephalin の立体構造の分子動力学的研究 : HAに現れる mixing 係数の効果
- 土屋 恭平,寺前 裕之,渡邊 寿雄 [他],石元 孝佳,長嶋 雲兵,Tsuchiya Kyouhei / Teramae Hiroyuki / Watanabe Toshio / Ishimoto Takayoshi / Nagashima Umpei,ツチヤ キョウヘイ,テラマエ ヒロユキ,ワタナベ トシオ,イシモト タカヨシ,ナガシマ ウンペイ
- Journal of computer chemistry, Japan 6(5), 275-282, 2007-12-15
- … Leu-EnkephalinとMet-Enkephalinの二種類のタンパク質を計算対象とした。 …
- NAID 130000056887
- ジアジリン型光反応性リガンドによるオピオイド結合細胞接着分子(OBCAM)の光アフィニティーラベリング
- 定金 豊,北本 英二郎,友廣 岳則 [他],木葉 敬子,川原 正博,畑中 保丸
- 九州保健福祉大学研究紀要 8, 179-185, 2007-03-25
- … しかしながら、[Leu]-エンケファリン,[D-Ala^2, D-Leu^5]-エンケファリンおよびβ-エンドルフィンを過剰に加えても、この複合体形成を阻害できなかった。 …
- NAID 110006407510
Related Links
- Leu-enkephalinとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Leu-enkephalinとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...
- either of two pentapeptides that bind to morphine receptors in the central nervous system and have opioid properties of relatively short duration; one pentapeptide (Met enkephalin) has the amino acid sequence Tyr-Gly-Gly-Phe-Met ...
Related Pictures
★リンクテーブル★
[★]
- 英
- opioid
- 同
- 類麻薬
- 関
- オピオイド受容体
作用
縮瞳
- モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)
オピオイドとオピオイド類似物質の作用
- GOO.552
+アゴニスト ーアンタゴニスト P partial agonist
各鎮痛薬のオピオイド受容体への作用
- μ受容体 κ受容体
- レミフェンタニル +++ ー
- フェンタニル +++ -
- モルヒネ +++ +
- ペチジン ++ +
- トラマドール + -
- ペンタゾシン ー ++
- ブプレノルフィン P ー
- ナロキソン ー -
[★]
ロイシンエンケファリン
- 関
- leucine enkephalin