同: drug-induced LQT
同: drug-induced LQT

WordNet

primarily temporal sense; being or indicating a relatively great or greater than average duration or passage of time or a duration as specified; "a long life"; "a long boring speech"; "a long time"; "a long friendship"; "a long game"; "long ago"; "an hour long"
(of speech sounds or syllables) of relatively long duration; "the English vowel sounds in `bate, `beat, `bite, `boat, `boot are long"
for an extended distance
for an extended time or at a distant time; "a promotion long overdue"; "something long hoped for"; "his name has long been forgotten"; "talked all night long"; "how long will you be gone?"; "arrived long before he was expected"; "it is long after your bedtime"
having or being more than normal or necessary:"long on brains"; "in long supply"
holding securities or commodities in expectation of a rise in prices; "is long on coffee"; "a long position in gold"
involving substantial risk; "long odds"
of relatively great height; "a race of long gaunt men"- Sherwood Anderson; "looked out the long French windows"
primarily spatial sense; of relatively great or greater than average spatial extension or extension as specified; "a long road"; "a long distance"; "contained many long words"; "ten miles long"
reason or establish by induction
cause to arise; "induce a crisis" (同)bring_on
produce electric current by electrostatic or magnetic processes (同)induct
cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
use recreational drugs (同)do drugs
administer a drug to; "They drugged the kidnapped tourist" (同)dose
a substance that is used as a medicine or narcotic
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
brought about or caused; not spontaneous; "a case of steroid-induced weakness"

PrepTutorEJDIC

(距離・物の長さが)『長い』 / (時間が)『長い』,長く続く / 《時間・距離などを表離などを表す語を伴って》長さが…の / 『長々しい』,あきあきする / (数量が標準よりも)『多い』,長い / (人が)やせてひょろ長い / 長く,長い間,久しく / …じゅう / ずっと(前に,後に) / 長い間
『熱望する』
〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

UpToDate Contents

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1. 後天性ＱＴ延長症候群 acquired long qt syndrome
2. I群抗不整脈薬の主な副作用 major side effects of class i antiarrhythmic drugs
3. 心不全患者において使用をさけるべき、または慎重に使用するべき薬 drugs that should be avoided or used with caution in patients with heart failure
4. QT延長症候群の病態生理 pathophysiology of the long qt syndrome
5. 抗レトロウイルス剤投与患者における悪性腫瘍に対する全身療法 systemic therapy for malignancy in patients on anti retroviral medications

English Journal

An update on risk factors for drug-induced arrhythmias.

Vlachos K1, Georgopoulos S1, Efremidis M1, Sideris A1, Letsas KP1.
Expert review of clinical pharmacology.Expert Rev Clin Pharmacol.2016 Jan;9(1):117-27. doi: 10.1586/17512433.2016.1100073. Epub 2015 Oct 13.
A variety of drugs, either anti-arrhythmics or non-antiarrhythmics, have been associated with drug-induced arrhythmias. Drug-induced arrhythmias are usually observed in the presence of long QT interval or Brugada electrocardiographic pattern. Clinical risk factors, such as female gender, structural
PMID 26460585

Predicting drug-induced QT prolongation and torsades de Pointes.

Roden DM1.
The Journal of physiology.J Physiol.2015 Dec 14. doi: 10.1113/JP270526. [Epub ahead of print]
Drugs used to treat cardiovascular disease as well as those used in the treatment of multiple other conditions can occasionally produce exaggerated prolongation of the QT interval on the electrocardiogram and the morphologically distinctive polymorphic ventricular tachycardia ("torsades de pointes")
PMID 26660066

A 2015 focus on preventing drug-induced arrhythmias.

Bossu A1, van der Heyden M1, de Boer TP1, Vos MA1.
Expert review of cardiovascular therapy.Expert Rev Cardiovasc Ther.2015 Nov 26:1-9. [Epub ahead of print]
Drug-induced Torsade de Pointes arrhythmia is a life-threatening adverse effect feared by pharmaceutical companies. For the last decade, the cardiac safety guidelines have imposed human ether-a-go-go-related gene channel blockade and prolongation of QT interval as surrogates for proarrhythmic risk p
PMID 26560188

Japanese Journal

QT延長をきたす薬物の知識 (特集救急医療に必要な不整脈診療の実際) -- (知っておくと役立つ不整脈の知識)

添木武
救急医学 = The Japanese journal of acute medicine 37(2), 212-217, 2013-02
NAID 40019592491

特別講演(第139回東邦医学会例会) 薬物性QT延長症候群 : 現状と展望

杉山篤
東邦医学会雑誌 = Journal of Medical Society of Toho University 59(3), 138-143, 2012-05
… 総説薬物性QT 延長症候群の発生を予測するためには，生体に投与された薬物が，心臓に分布し，K＋チャネルを遮断，その結果QT が延長して，素因のある病的心においてはtorsades de pointes（TdP）という致死性不整脈を起こすまでの各段階を検証する必要があり，それに特化したモデルが必要である．われわれは「非臨床で得られた情報を薬物性QT 延長症候群の臨床へ外挿する」，い …
NAID 120005306349

Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome : Development of Chronic Atrioventricular Block Model of Microminipig

Sugiyama Atsushi,Nakamura Yuji,Akie Yasuki [他],SAITO Hiroyuki,IZUMI Yasukatsu,YAMAZAKI Hiroshi,KANEKO Naoki,ITOH Katzuhiko
Journal of pharmacological sciences 115(2), 122-126, 2011-02-20
… A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc. (Shizuoka). … Oral administration of <I>dl</I>-sotalol (10 mg/kg) to the AV-block Microminipig prolonged the QT interval; …
NAID 10029891843